19 completed, 2 withdrawn, 1 recruiting, 1 terminated. 19 Not applicable, 2 Phase 3, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 15, Withdrawn 2, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Electronic cigarette: new trials by email Literature Review of Electronic cigarette trials Research Report on Electronic cigarette
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Switching to E-cigarettes in Smokers Not Interested in Quitting Varenicline Tartrate, Placebo, Electronic cigarette - Smoking Reduction | Phase 3 | Recruiting | University of Kansas Medical Center | 500 | 2023-07-17 | 2026-10-13 |
| Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes Nicotine Replacement, Questionnaire Administration, Electronic Cigarette - Cigarette Smoking-Related Carcinoma | Not applicable | Completed | M.D. Anderson Cancer Center | 169 | 2022-06-02 | 2026-01-28 |
| E-cigarettes for Harm Reduction in Adults With Asthma Nicotine - Smoking, Asthma | Not applicable | Completed | Brown University | 17 | 2022-05-01 | 2025-11-18 |
| Methadone-Maintained Smokers Switching to E-Cigarettes Electronic Cigarette, Nicotine Lozenge - Nicotine Dependence, Electronic Cigarette Use | Phase 4 | Completed | Butler Hospital | 183 | 2022-03-31 | 2026-08-20 |
| Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study] Electronic Cigarette, Oral Nicotine Pouch - Tobacco Use, Tobacco Smoking | Not applicable | Completed | Roswell Park Cancer Institute | 15 | 2021-10-21 | 2023-10-26 |
| Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH Electronic Cigarette - Cardiovascular Risk Factor, Nicotine Dependence | Not applicable | Completed | University of California, San Francisco | 14 | 2021-01-04 | 2025-07-15 |
| Effects of Electronic Cigarettes in Cigarette Smokers With Mild to Moderate COPD Electronic cigarette - COPD, Tobacco Use | Not applicable | Withdrawn | Massachusetts General Hospital | 2019-10-01 | 2019-11-06 | |
| Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power Electronic Cigarette - Cardiovascular Risk Factor, Nicotine Dependence | Not applicable | Completed | University of California, San Francisco | 16 | 2019-03-26 | 2024-07-01 |
| Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette - Cigarette Smoker, Current Every Day Smoker | Early Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 66 | 2018-09-17 | 2026-04-23 |
| Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT) Electronic Cigarette - Smoking, Tobacco Use | Not applicable | Completed | Medical University of South Carolina | 638 | 2018-05-24 | 2023-09-11 |
| Investigation of the Effects of Electronic Cigarettes on Vascular Health Electronic cigarette, traditional cigarette, (sham cigarette) - no actual exposure to cigarettes - Vascular Health | Not applicable | Terminated | Memorial Sloan Kettering Cancer Center | 12 | 2017-02-01 | 2021-06-18 |
| The Effects of Electronic Cigarette Smoking on the Arterial Wall and Endothelial Glycocalyx Properties of Smokers Electronic cigarette, Conventional cigarette - Smoking Cessation | Not applicable | Unknown | University of Athens | 90 | 2017-01-31 | 2020-04-06 |
| Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study - Cigarette Smoker, Current Smoker | Not applicable | Completed | Roswell Park Cancer Institute | 36 | 2016-03-16 | 2018-06-12 |
| The Use of Nicotine Patches Together With E-cigarettes (With and Without Nicotine) for Smoking Cessation Nicotine patch, e-cigarette, Nicotine - Smoking Cessation | Phase 3 | Completed | University of Auckland, New Zealand | 1124 | 2016-03-01 | 2021-08-19 |
| Effects of Electronic Cigarette Use on the Lungs Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis - Current Smoker, Never Smoker | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 142 | 2015-12-08 | 2024-07-30 |
| Electronic Cigarette Use and Quitting in Youth Electronic cigarette - Smoking | Completed | The University of Hong Kong | 189 | 2015-09-01 | 2016-10-31 | |
| Clinical Pharmacology of Electronic Cigarettes Tobacco Cigarette, Electronic Cigarette - Nicotine Dependence | Not applicable | Completed | University of California, San Francisco | 38 | 2015-07-23 | 2023-06-22 |
| Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes Electronic Cigarette, Tobacco Cigarette - Tobacco Smoking, Nicotine Dependence | Not applicable | Completed | Laureate Institute for Brain Research, Inc. | 27 | 2015-01-01 | 2017-06-28 |
| A Trial of E-cigarettes in Current Cigarette Smokers electronic cigarette, cigarette group - Smoking, Nicotine Dependence | Not applicable | Completed | Medical University of South Carolina | 68 | 2014-11-01 | 2018-04-04 |
| Effects of E-smoke on Levels of Endothelial Progenitor Cells and Microparticles in Healthy Volunteers Electronic cigarette - Healthy | Not applicable | Completed | Karolinska Institutet | 16 | 2014-10-01 | 2021-10-11 |
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Vaping (13) · Tobacco Use Disorder (8) · Smoking (6) · Smoking Cessation (4) · Tobacco Use (3) · Cigarette Smoking (2) · Tobacco Smoking (2) · Asthma (1) · Harm Reduction (1) · Health Behavior (1) · Pulmonary Disease, Chronic Obstructive (1) · Smoking Reduction (1) · Tobacco Use Cessation (1)
University of California, San Francisco (3) · Medical University of South Carolina (2) · Ohio State University Comprehensive Cancer Center (2) · Roswell Park Cancer Institute (2) · Brown University (1) · Butler Hospital (1) · Karolinska Institutet (1) · Laureate Institute for Brain Research, Inc. (1) · M.D. Anderson Cancer Center (1) · Massachusetts General Hospital (1) · Memorial Sloan Kettering Cancer Center (1) · New York State Psychiatric Institute (1) · Rutgers, The State University of New Jersey (1) · The University of Hong Kong (1) · UConn Health (1)
United States (18) · Greece (1) · Hong Kong (1) · New Zealand (1) · Sweden (1)
Gideon St. Helen, PhD (2) · Peter Shields, MD (2) · Barney Vaughan, MD (1) · Cheryl Oncken, M.D. (1) · Ignatios Ikonomidis, Dr (1) · Jason Robinson (1) · Maciej Goniewicz, PhD (1) · Man Ping Wang, PhD (1) · Martin Mahoney (1) · Matthew J Carpenter, PhD (1) · Natalie Walker, PhD (1) · Neal L Benowitz, MD (1) · Nicole Nollen, PhD (1) · Roman Shingarev, MD (1)
PMID 25762758, PMID 29335291, PMID 31515173, PMID 31773209, PMID 33208019, PMID 34611902, PMID 37753443, PMID 39868569, PMID 40394619, PMID 41051837
U54HL147127 (2), P20GM130414 (1), P30CA016056 (1), P50DA009236 (1), R01CA210625 (1), R01DA037446 (1), R01DA039264 (1), R01DA052907 (1), R21DA037407 (1), U01DA045530 (1), U01DA047875 (1)