12 completed, 2 recruiting, 1 terminated, 1 unknown. 9 Phase 2, 3 Early Phase 1, 2 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 8, Recruiting 1 |
| Early Phase 1 | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Not applicable | 1 | Completed 1 |
Follow d-amphetamine: new trials by email Literature Review of d-amphetamine trials Research Report on d-amphetamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder 3,4-methylenedioxymethamphetamine, d-amphetamine, Therapy - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Stephen Robert Marder | 40 | 2025-03-01 | 2026-08-19 |
| [C-11]NPA PET-amphetamine in Cocaine Use Disorders Baseline [C-11]NPA PET Scan, d-amphetamine, Post-amphetamine [C-11]NPA PET Scan - Cocaine Use Disorder | Early Phase 1 | Recruiting | Rajesh Narendran | 30 | 2021-01-31 | 2026-07-06 |
| Pharmacologic Augmentation of Targeted Cognitive Training in Schizophrenia d-amphetamine, Placebo - Schizophrenia, Schizoaffective Disorder | Phase 2 | Completed | University of California, San Diego | 68 | 2020-11-09 | 2025-12-17 |
| Brain Mechanisms in Young Adults d-amphetamine, [C-11]NPA - Cocaine-Related Disorders | Early Phase 1 | Completed | Gale Richardson | 13 | 2018-01-24 | 2020-09-03 |
| A Study to Determine the Abuse Potential of Tozadenant Relative to D-Amphetamine and Placebo When Administered Orally in Healthy, Non-Dependent, Recreational Polydrug Users Tozadenant, Placebo oral tablet, d-amphetamine - Abuse Potential | Phase 1 | Terminated | Biotie Therapies Inc. | 26 | 2017-09-18 | 2018-08-13 |
| Targeting Anhedonia in Cocaine Use Disorder d-amphetamine, Contingency management, Placebo (for d-amphetamine) - Cocaine-Related Disorders, Anhedonia | Phase 2 | Completed | University of Illinois at Chicago | 57 | 2017-02-01 | 2024-08-09 |
| Decision Making Study in Young and Middle-Aged Adults: Part II Dextroamphetamine, Placebo, [18F]Fallypride - Healthy Adults | Phase 1 | Completed | Vanderbilt University | 65 | 2016-03-31 | 2019-06-27 |
| Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia. Dextroamphetamine, Placebo - Schizophrenia | Phase 2 | Completed | University of California, San Diego | 82 | 2014-07-01 | 2021-08-17 |
| Individual Differences in the Response to Drugs THC, AMP, ALC - Healthy | Not applicable | Completed | University of Chicago | 28 | 2013-07-01 | 2016-11-29 |
| Study to Evaluate Safety & Efficacy of d-Amphetamine Transdermal System vs Placebo in Children & Adolescents With ADHD d-Amphetamine Transdermal Patch, Placebo patch - Attention Deficit Hyperactivity Disorder | Phase 2 | Completed | Noven Pharmaceuticals, Inc. | 110 | 2012-10-01 | 2023-12-21 |
| Cocaine Use Disorder and Cortical Dopamine d-amphetamine, [C-11]FLB 457 - Cocaine Dependence | Early Phase 1 | Completed | University of Pittsburgh | 30 | 2010-06-02 | 2020-06-04 |
| D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement Haloperidol, Fluphenazine, Dexedrine - Pathological Gambling | Phase 2 | Completed | Centre for Addiction and Mental Health | 60 | 2009-09-01 | 2016-04-25 |
| Substance Abuse Pre-Treatment Screening Study modafinil, d-amphetamine, L-Dopa - Cocaine Abuse, Cocaine Dependence | Unknown | The University of Texas Health Science Center, Houston | 7500 | 2005-10-01 | 2023-12-20 | |
| Amphetamine-Enhanced Stroke Recovery Dextroamphetamine, Physical Therapy, Placebo - Stroke | Phase 2 | Completed | Duke University | 99 | 2001-04-01 | 2013-07-23 |
| Dextroamphetamine as an Adjunct in Cocaine Treatment - 1 Dextroamphetamine, D-Amphetamine, Placebo - Cocaine-Related Disorders, Substance-Related Disorders | Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 120 | 1997-08-01 | 2017-01-12 |
| Dextroamphetamine-Cocaine Behavioral Intervention - 5 Dextroamphetamine, D-amphetamine, placebo - Cocaine-Related Disorders | Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 54 | 1995-09-01 | 2017-01-12 |
Cocaine-Related Disorders (6) · Substance-Related Disorders (3) · Psychotic Disorders (2) · Schizophrenia (2) · Alcoholism (1) · Anhedonia (1) · Attention Deficit Disorder with Hyperactivity (1) · Chronic Pain (1) · Gambling (1) · Mental Disorders (1) · Opioid-Related Disorders (1) · Stress Disorders, Post-Traumatic (1) · Stroke (1)
National Institute on Drug Abuse (NIDA) (2) · University of California, San Diego (2) · Biotie Therapies Inc. (1) · Centre for Addiction and Mental Health (1) · Duke University (1) · Gale Richardson (1) · Noven Pharmaceuticals, Inc. (1) · Rajesh Narendran (1) · Stephen Robert Marder (1) · The University of Texas Health Science Center, Houston (1) · University of Chicago (1) · University of Illinois at Chicago (1) · University of Pittsburgh (1) · Vanderbilt University (1)
United States (13) · Canada (2)
John Grabowski, Ph.D. (2) · Angela L Stotts, PhD (1) · Daniela Lobo, MD, Ph.D. (1) · David Zald, Zald (1) · Frederick G Moeller, MD (1) · Harriet de Wit, PhD (1) · James Waxmonsky, MD (1) · Joy M. Schmitz, PhD (1) · Larry B Goldstein, MD (1) · Margaret C Wardle, Ph.D. (1) · Michael McDonnell, MD (1) · Neal R Serdlow, M.D., Ph.D. (1) · Neal R. Swerdlow, M.D., Ph.D. (1) · Rajesh Narendran (1) · Stephanie L Taylor, PhD (1)
PMID 26513587, PMID 30167675, PMID 35020462, PMID 36919514, PMID 37339441
R01DA026472 (2), P50DA009262 (1)