99 completed, 44 unknown, 16 recruiting, 13 not yet recruiting. 189 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 189 | Completed 99, Unknown 44, Recruiting 16, Not yet recruiting 13, Terminated 8, Withdrawn 5, Active not recruiting 3, Suspended 1 |
Follow Cryotherapy: new trials by email Literature Review of Cryotherapy trials Research Report on Cryotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cryotherapy vs Lidocaine Spray for Oral Mucositis Oral Cryotherapy, Topical Lidocaine Spray - Cancer | Not applicable | Not yet recruiting | Hanady Jabbar Mahmood | 60 | 2026-12-31 | 2026-07-27 |
| Necrosectomy With Cryotechnology for Accelerated Removal Cryotechnology Necrosectomy Procedure - Pancreatic Necrosis, Acute Pancreatitis | Not applicable | Recruiting | Christopher C. Thompson, MD, MSc | 20 | 2026-12-01 | 2026-06-25 |
| Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Cryotherapy - ME/CFS, Fibromyalgia (FM) | Not applicable | Not yet recruiting | Oxford Brookes University | 40 | 2026-10-01 | 2026-10-14 |
| Holistic Healing for Knee Osteoarthritis Trayodashang Guggulu, Ashwagandha Churna, Janubasti - Knee Osteoarthritis (Knee OA) | Not applicable | Not yet recruiting | All India Institute of Medical Sciences, Jodhpur | 300 | 2026-09-01 | 2026-08-27 |
| Cryo Nerve Block Trial Cryotherapy, PAiN - multimodal analgesia - Intercostal Nerve Block, Cryo Analgesia | Not applicable | Recruiting | St. Antonius Hospital | 150 | 2026-09-01 | 2026-06-26 |
| Cryotherapy for Post-Hemorrhoidectomy Pain Milligan-Morgan Hemorrhoidectomy with Cryotherapy, Miligan-Morgan haemorroidectomy - Hemorrhoid, Hemorrhoidectomy | Not applicable | Not yet recruiting | Cairo University | 114 | 2026-08-04 | 2026-07-22 |
| Effect of Oral Ice Chips to Prevent Chemotherapy-Induced Oral Mucositis in Patient With Solid Tumor Treated With 5 Fluorouracil and Methotrexate Oral Cryotherapy (Ice Chips), Standard Oral Care (Mouthwash) - Chemotherapy Induced Oral Mucositis | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 102 | 2026-07-15 | 2026-06-16 |
| Virtual Reality and Cryotherapy for Postoperative Pain and Anxiety After Cesarean Section Virtual Reality, Cryotherapy - Postoperative Pain, Anxiety | Not applicable | Not yet recruiting | Shahid Beheshti University of Medical Sciences | 120 | 2026-07-12 | 2026-07-14 |
| Effect of Intracanal Cryotherapy on Postoperative Endodontic Pain root canal treatment and cryotherapy - Periapical Periodontitis, Asymptomatic Irreversible Pulpitis | Not applicable | Completed | Recep Tayyip Erdogan University | 132 | 2026-05-11 | 2026-07-17 |
| Post-Market Registry of Transbronchial Cryo-assisted RFA During Routine Standard Bronchoscopic Tumor Stagng and Resection Cryotherapy - NSCLC, Cryotherapy | Not applicable | Not yet recruiting | Elisabethinen Hospital | 20 | 2026-05-01 | 2026-04-15 |
| CRYO-1: Cryoablation in Elderly Patients With Early-Stage Breast Cancer. Cryoablation / Cryotherapy - Breast Cancer Stage I, Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Not applicable | Not yet recruiting | St. Antonius Hospital | 61 | 2026-04-01 | 2026-03-23 |
| High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults High Intensity Focused Ultrasound, Cryotherapy - Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma | Not applicable | Not yet recruiting | Jussi Salonen | 294 | 2026-04-01 | 2026-02-03 |
| Evaluatation of a Microcurrent + Cold Therapy Device Acute Microcurrent Treatment, Acute Microcurrent + cold therapy, 8-week Chronic Use of Microcurrent + Cold Therapy - Skin Health | Not applicable | Completed | Therabody, Inc. | 112 | 2026-03-30 | 2026-10-01 |
| Comparing Pre-Anesthetic Approaches in Dentistry 10% lidocaine spray, Ice Pen (Cryotherapy) - Injection Site Pain, Pain | Not applicable | Completed | Harran University | 192 | 2026-02-23 | 2026-09-10 |
| Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible Pulpitis infiltration anesthesia alone, mandibular anesthesia alone, infiltration anesthesia combined with cryotherapy - Irreversible Pulpitis, Cryotherapy | Not applicable | Not yet recruiting | TC Erciyes University | 100 | 2026-01-30 | 2026-02-11 |
| Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps Cryotherapy - Healthy | Not applicable | Suspended | Wake Forest University | 24 | 2026-01-20 | 2026-08-21 |
| Effect of Cold Application and Artificial Saliva in the Prevention of Chemotherapy-Induced Oral Mucositis cold application, Artificial Saliva - Oral Mucositis | Not applicable | Not yet recruiting | Karbala University | 60 | 2026-01-01 | 2025-12-26 |
| Intercostal Cryoanalgesia in Double Lung Transplant Recipients Atricure CryoSPHERE MAX Probe - Post-operative Pain Management | Not applicable | Recruiting | University of California, Los Angeles | 148 | 2025-12-16 | 2026-03-05 |
| Effects of Reflexology and Cold Application Before Chest Tube Removal in CABG Patients Reflexology, Cryotherapy alone - Pain, Acute Post-Operative, Anxiety | Not applicable | Completed | Ankara University | 108 | 2025-12-15 | 2026-10-21 |
| Oral Cryotherapy to Decrease Taste Changes in Prostate Cancer Patients Receiving Taxane Chemotherapy Best Practice, Oral Cryotherapy, Survey Administration - Prostate Carcinoma | Not applicable | Completed | City of Hope Medical Center | 2 | 2025-12-08 | 2026-10-16 |
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Pain, Postoperative (19) · Pain (15) · Breast Neoplasms (11) · Warts (8) · Uterine Cervical Dysplasia (7) · Osteoarthritis, Knee (6) · Peripheral Nervous System Diseases (6) · Stomatitis (6) · Neoplasms (5) · Agnosia (4) · Inflammation (4) · Motor Activity (4) · Prostatic Neoplasms (4) · Anxiety Disorders (3) · Fatigue (3)
Cairo University (7) · Cukurova University (4) · Ain Shams University (3) · Centre Leon Berard (3) · Minia University (3) · National Taiwan University Hospital (3) · The 306 Hospital of People's Liberation Army (3) · Universidade Federal de Sao Carlos (3) · Boston Scientific Corporation (2) · Centre Hospitalier Universitaire de Besancon (2) · Chung Shan Medical University (2) · Combined Military Hospital Abbottabad (2) · Dokuz Eylul University (2) · Mansoura University (2) · Riphah International University (2)
United States (35) · Egypt (19) · Turkey (Türkiye) (18) · France (14) · Brazil (13) · Taiwan (9) · Pakistan (8) · China (7) · Canada (6) · India (4) · Spain (4) · Italy (3) · Netherlands (3) · United Kingdom (3) · Norway (2)
Shichao Lu, MD (3) · Carlos M Pastre, PhD (2) · Cynthia S Firnhaber, MD (2) · Maram F Obeid, Professor (2) · Rajeev Muni, FRSCS (2) · Abbas Ardehali, MD (1) · Adeel Dr Siddiqui, FCPS (1) · Aftab Ahmed Mirza Baig, MSAPT (1) · Ahmed Hamdy Wahba, Assistant professor (1) · Aminur Rahman Shaheen, PhD (1) · Ann K Ketz, PhD (1)
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P30CA015083 (1), P30CA033572 (1)