8 completed, 4 terminated, 4 unknown, 1 active not recruiting. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Completed 8, Terminated 4, Unknown 4, Active not recruiting 1, Enrolling by invitation 1, Recruiting 1, Withdrawn 1 |
Follow Cryotherapy: new trials by email Literature Review of Cryotherapy trials Research Report on Cryotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisors Cryotherapy - Symptomatic Irreversible Pulpitis (SIP) | Phase 4 | Recruiting | Ondokuz Mayıs University | 98 | 2025-12-31 | 2026-04-08 |
| Cryotherapy as a Topical Anesthetic in Healthy Children Cryotherapy, topical anesthetic, Topical anesthetic gel - Healthy, Topical Anesthesia | Phase 4 | Completed | Ondokuz Mayıs University | 100 | 2025-09-01 | 2026-02-09 |
| Efficacy and Safety of Cryotherapy Versus 5-Fluorouracil in the Treatment of Actinic Keratosis Cryotherapy, 5Fluorouracil - Actinic Keratoses | Phase 4 | Enrolling by invitation | University of California, Davis | 73 | 2024-07-01 | 2026-07-06 |
| Effect of Intra-Canal Cryotherapy on Postoperative Pain After Endodontic Procedures cryotherapy with sterile saline at 2.5ºC, control with sterile saline at room temperature - Endodontically Treated Teeth, Post Operative Pain | Phase 4 | Unknown | Ajman University | 120 | 2023-05-15 | 2023-11-18 |
| Cryotherapy in Combination With Red Light PDT for Actinic Keratosis of Full Face Ameluz 10% Topical Gel, Red Light PDT, Cryotherapy - Actinic Keratoses | Phase 4 | Active not recruiting | Psoriasis Treatment Center of Central New Jersey | 40 | 2023-05-03 | 2026-10-14 |
| Cold Atmospheric Plasma Device for Pediatric Molluscum and Verruca Floating electrode-dielectric barrier device (FE-DBD) cold atmospheric plasma (CAP), Cryotherapy, Canthardin Collodion - Verruca Vulgaris, Molluscum Contagiosum Skin Infection | Phase 4 | Completed | Medical University of South Carolina | 17 | 2021-12-02 | 2024-04-05 |
| Cryotherapy Versus Steroids In Alopecia Areata:Trichoscopic Evaluation Cryotherapy, Triamcinolone acetonide injection - Alopecia Areata | Phase 4 | Unknown | Assiut University | 40 | 2018-11-01 | 2018-03-22 |
| Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts Measles-Mumps-Rubella Vaccine, cryotherapy - Common Wart, Plantar Wart | Phase 4 | Completed | Assiut University | 48 | 2017-08-01 | 2020-06-16 |
| Efficacy of Ingenol Mebutate on Actinic Keratoses and Field Cancerization vs Cryotherapy Ingenol mebutate, cryotherapy - Actinic Keratosis | Phase 4 | Completed | University of Campania Luigi Vanvitelli | 50 | 2017-04-12 | 2019-09-24 |
| Cryotherapy Combine Icotinib for Advanced NSCLC Treatment Cryotherapy, Icotinib - Lung Neoplasms | Phase 4 | Completed | Fuda Cancer Hospital, Guangzhou | 60 | 2016-04-01 | 2020-05-27 |
| An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst polidocanol, infra-red coagulation, cryotherapy - Ganglion Cysts | Phase 4 | Terminated | University of Edinburgh | 10 | 2015-07-27 | 2024-05-30 |
| Investigating Veregen ™ 15% Ointment Treatment For Non-facial Verrucae in Pediatric Patients: A Pilot Study Veregen only, Cryotherapy and Veregen - Verruca, Warts | Phase 4 | Completed | University of Texas Southwestern Medical Center | 28 | 2015-07-01 | 2017-09-08 |
| Safety and Efficacy of Ingenol Mebutate 0.05% Gel When Used After Cryotherapy in the Hypertrophic Actinic Keratoses Ingenol Mebutate, Cryotherapy - Actinic Keratoses | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 16 | 2013-04-01 | 2017-04-26 |
| Cryotherapy and Laser Therapy on Muscle Damage Cryotherapy, Laser therapy - Myalgia [C05.651.542] | Phase 4 | Completed | Universidade Federal do Rio Grande do Norte | 60 | 2013-03-01 | 2014-12-31 |
| Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm - Actinic Keratosis | Phase 4 | Unknown | Frankel, Amylynne, M.D. | 20 | 2010-10-01 | 2011-06-22 |
| Comparison of Five Treatments in Patients With Plantar Warts Salicylate ointment, Imiquimod, 5-Fluoro-Uracil - Plantar Warts | Phase 4 | Terminated | Assistance Publique - Hôpitaux de Paris | 358 | 2010-02-01 | 2017-01-11 |
| CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Cryo Spray Ablation Group 1, Cryo Spray Ablation Group 2 - Radiation Proctitis, Radiation Induced Proctitis | Phase 4 | Withdrawn | CSA Medical, Inc. | 2008-10-01 | 2015-08-07 | |
| Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") CryoSpray Ablation - Lung Diseases, Obstructive, Sarcoidosis | Phase 4 | Terminated | CSA Medical, Inc. | 5 | 2008-10-01 | 2015-08-18 |
| Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space("ICE PLS") CryoSpray Ablation (TM) System - Cancer, Pleural Neoplasms | Phase 4 | Terminated | CSA Medical, Inc. | 3 | 2008-08-01 | 2015-07-16 |
| Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer Endoscopic spray cryotherapy - Barrett's Esophagus | Phase 4 | Unknown | Walter Reed Army Medical Center | 100 | 2007-03-01 | 2008-07-24 |
Keratosis, Actinic (5) · Warts (3) · Lung Neoplasms (2) · Adenocarcinoma Of Esophagus (1) · Alopecia Areata (1) · Barrett Esophagus (1) · Ganglion Cysts (1) · Granulomatosis with Polyangiitis (1) · Keratosis (1) · Lung Diseases, Obstructive (1) · Neoplasms (1) · Pain, Postoperative (1) · Pleural Neoplasms (1) · Recurrent respiratory papillomatosis (1) · Rhinoscleroma (1)
CSA Medical, Inc. (3) · Assiut University (2) · Ondokuz Mayıs University (2) · Ajman University (1) · Assistance Publique - Hôpitaux de Paris (1) · Frankel, Amylynne, M.D. (1) · Fuda Cancer Hospital, Guangzhou (1) · Icahn School of Medicine at Mount Sinai (1) · Medical University of South Carolina (1) · Psoriasis Treatment Center of Central New Jersey (1) · Universidade Federal do Rio Grande do Norte (1) · University of California, Davis (1) · University of Campania Luigi Vanvitelli (1) · University of Edinburgh (1) · University of Texas Southwestern Medical Center (1)
United States (9) · Egypt (2) · Turkey (Türkiye) (2) · France (1) · Italy (1) · United Arab Emirates (1) · United Kingdom (1)
Daniel Eisen, MD (1) · Firas H Elmsmari, PhD (1) · Gary Goldenberg, MD (1) · Gary S Goldenberg, MD (1) · Giuseppe Argenziano, Prof (1) · Gordon Downie, M.D., Ph.D (1) · John D Horwhat, MD (1) · Lara Wine Lee, MD, PhD (1) · Lizhi Liu, M.D. (1) · Mary Lee Krinsky, D.O. (1) · Michael Machuzak, M.D. (1) · Stephen A Holme, MBChB (1)
PMID 11966728, PMID 12533168, PMID 15168956, PMID 18067627, PMID 20231500, PMID 20725550, PMID 24672213, PMID 27672408, PMID 39197495, PMID 40743833, PMID 7947197