31 completed, 7 unknown, 2 not yet recruiting, 2 terminated. 44 Phase 2, 7 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 44 | Completed 31, Unknown 7, Not yet recruiting 2, Terminated 2, Active not recruiting 1, Recruiting 1 |
| Phase 3 | 7 | Completed 3, Unknown 3, Not yet recruiting 1 |
| Phase 1 | 4 | Completed 4 |
Follow Calcium: new trials by email Literature Review of Calcium trials Research Report on Calcium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improved Treatment and Monitoring of Alzheimer's Disease Semaglutide (Rybelsus®) combined with other interventions, Placebo, Semaglutide (Rybelsus®) - Alzheimer Disease (AD) | Phase 2 | Not yet recruiting | Rune Skovgaard Rasmussen | 180 | 2026-01-01 | 2025-08-22 |
| Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity Bimagrumab, Tirzepatide, Calcium/Vitamin D - Obesity | Phase 2 | Recruiting | Massachusetts General Hospital | 63 | 2025-11-05 | 2026-03-27 |
| Calcium Administration in Life-saving Management During Massive Hemorrhage calcium gluconate, Control: Placebo - Massive Hemorrhage, Trauma | Phase 2 / Phase 3 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 81 | 2025-05-01 | 2025-02-11 |
| Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea Next Generation ORS (oral rehydration solution) (including placebo, Current standard control ORS (oral rehydration solution) - Diarrhea, Cholera | Phase 2 / Phase 3 | Completed | University of Florida | 396 | 2023-08-21 | 2026-04-14 |
| Pre-diltiazem, Calcium Versus Placebo for Atrial Fibrillation With Rapid Ventricular Response Placebo, Calcium - Atrial Fibrillation With Rapid Ventricular Response, Hypotension | Phase 2 | Unknown | Ascension Health | 378 | 2023-01-26 | 2023-01-20 |
| Vitamin D and Calcium Supplementation in Breast Cancer Letrozole 2.5mg, Letrozole + vitamin D3 and calcium - Breast Cancer | Phase 2 / Phase 3 | Unknown | Tanta University | 40 | 2022-11-01 | 2023-12-01 |
| Effects of Low Dose Aspirin in Bipolar Disorder (The A-Bipolar RCT) acetylsalicylic acid, Calcium - Bipolar Disorder | Phase 2 | Completed | Lars Vedel Kessing | 250 | 2022-01-20 | 2025-01-29 |
| Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection Metformin Hydrochloride, Calcium and Vitamin D - Endoplasmic Reticulum Stress, Viral Infection | Phase 2 | Completed | Singapore General Hospital | 32 | 2021-10-22 | 2024-04-17 |
| Fluoxetine Mitigation Mental Health Study for Patients With Musculoskeletal Trauma Fluoxetine, Calcium - Musculoskeletal Injury | Phase 2 | Completed | University of Florida | 55 | 2021-09-01 | 2026-05-14 |
| Effect of Soluble Corn Fiber Supplementation for 1 Year on Bone Metabolism in Adolescents Soluble Corn Fiber (SCF) without Calcium, Soluble Corn Fiber (SCF) + Calcium, Placebo - Osteoporosis | Phase 2 | Completed | Florida International University | 177 | 2020-02-10 | 2025-11-10 |
| RANKL Inhibition and Mammographic Breast Density Denosumab, Placebo, Calcium - Dense Breasts | Phase 2 | Active not recruiting | Washington University School of Medicine | 210 | 2019-08-27 | 2026-10-09 |
| Calcium Chloride for Prevention of Uterine Atony During Cesarean Calcium Chloride, Placebo - Uterine Atony, Uterine Atony With Hemorrhage | Phase 1 / Phase 2 | Completed | Stanford University | 40 | 2019-03-15 | 2022-04-28 |
| Study Comparing Denosumab With Standard Treatment in Urothelial Cancer Patients With Bone Metastases Denosumab, Denosumab Placebo, Gemcitabine - Urothelial Carcinoma, Kidney Cancer | Phase 2 | Completed | University Health Network, Toronto | 6 | 2018-09-04 | 2021-11-23 |
| A Trial of C13-CAC Breath Test in PPI Resistant GERD Patients Calcium (13C)Carbonate, Gastric acid inhibitors, Gastric pH monitoring - Gastroesophageal Reflux Disease | Phase 2 | Completed | Otsuka Pharmaceutical Co., Ltd. | 55 | 2017-10-31 | 2019-04-01 |
| A Study in Adult Patients With Type I, III or IV Osteogenesis Imperfecta Treated With BPS804 setrusumab, Calcium, Vitamin D - Osteogenesis Imperfecta, Type I, Osteogenesis Imperfecta Type III | Phase 2 | Completed | Ultragenyx Pharmaceutical Inc | 112 | 2017-09-11 | 2023-07-05 |
| Effects of Genistein Aglycone in Glucocorticoid Induced Osteoporosis Genistein aglycone, Alendronate Oral Tablet, Calcium + vitamin D3 tablet - Osteoporosis, Steroid Induced | Phase 2 / Phase 3 | Unknown | University of Messina | 200 | 2017-01-19 | 2017-03-03 |
| Alendronate Treatment of Osteoporosis in Rheumatoid Arthritis Placebo, Alendronate, Calcium - Rheumatoid Arthritis, Osteoporosis | Phase 2 | Completed | University of Aarhus | 69 | 2015-12-01 | 2023-11-27 |
| Opioid Induced Gait Variability Tapentadol 50 mg Oral Tablet, Tramadol Hydrochloride 100 mg Extended Release Oral Tablet, Placebo Oral Tablet - Opioid Induced Motor Disturbances | Phase 1 / Phase 2 | Completed | Frederiksberg University Hospital | 24 | 2015-05-19 | 2017-11-06 |
| Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation Pamidronate, Calcium and vitamin D - Osteopenia, Osteoporosis | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 63 | 2015-02-01 | 2024-02-20 |
| GAit, MEmory, Dietary and Vitamin D Yogurt supplemented with vitamin D and calcium, Yogurt not supplemented with vitamin D and calcium - Memory Complaint Without Cognitive Decline | Phase 2 / Phase 3 | Completed | University Hospital, Angers | 40 | 2014-09-01 | 2016-09-22 |
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Osteoporosis (13) · Breast Neoplasms (4) · Bone Diseases, Metabolic (3) · Hypocalcemia (3) · Wounds and Injuries (2) · Adenomatous Polyps (1) · Alzheimer Disease (1) · Arthralgia (1) · Arthritis, Rheumatoid (1) · Atrial Fibrillation (1) · Bipolar Disorder (1) · Body Weight Changes (1) · Bone Diseases (1) · Bone Resorption (1) · Carcinoma, Transitional Cell (1)
Otsuka Pharmaceutical Co., Ltd. (2) · University of Florida (2) · Amgen (1) · Asan Medical Center (1) · Ascension Health (1) · Copenhagen University Hospital, Rigshospitalet (1) · Duke University (1) · Elvir SAS (1) · Emory University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Florida International University (1) · Frederiksberg University Hospital (1) · Helen Hayes Hospital (1) · Lars Vedel Kessing (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1)
United States (20) · Denmark (5) · France (3) · Canada (2) · Japan (2) · Austria (1) · Bangladesh (1) · Belgium (1) · China (1) · Egypt (1) · Germany (1) · Italy (1) · Poland (1) · Singapore (1) · South Korea (1)
Adetunji T Toriola, M.D., Ph.D. (1) · Amie Hiller, MD BS (1) · Ben Chue, MD (1) · Berdine R Martin, PhD (1) · Brendan Carvalho, MBBCh FRCA (1) · Bruno Niederle, Prof., MD (1) · Connie M Weaver, PhD (1) · Cristina Palacios, PhD (1) · Edward G. Shaw, MD (1) · Ellen Hauge, MD, PhD (1) · Francesco Squadrito, MD (1) · Hannah Linden (1) · Henning Bliddal, DMSc (1) · Jennifer Hagen, MD (1) · Jenny GH Low, MRCP (UK) (1)
PMID 14988471, PMID 17911175, PMID 18501061, PMID 19117033, PMID 19244376, PMID 19258546, PMID 19861511, PMID 20056649, PMID 20332274, PMID 20516268, PMID 21084270, PMID 21724580, PMID 22149065, PMID 22964475, PMID 23170065, PMID 24064689, PMID 24120120, PMID 24128322, PMID 24166893, PMID 27496946, PMID 29126319, PMID 30231890, PMID 30256811, PMID 30355512, PMID 30649458, PMID 30914274, PMID 33809538, PMID 34508607, PMID 35447502, PMID 35506389, PMID 35978446, PMID 36410666, PMID 38178229, PMID 38979716, PMID 39012717, PMID 39413989, PMID 39557557, PMID 41319159, PMID 41531256, PMID 41936980, PMID 8156110
2008 (1), 2015 (1), 2016 (1), R01AR040736 (1), R01AR056651 (1), R01CA104637 (1), R01HD098589 (1), R01HL048846 (1), R21AI169282 (1), R37CA235602 (1), U10CA081851 (1)