18 completed, 4 unknown, 2 not yet recruiting, 1 enrolling by invitation. 26 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 26 | Completed 18, Unknown 4, Not yet recruiting 2, Enrolling by invitation 1, Recruiting 1 |
Follow Berberine: new trials by email Literature Review of Berberine trials Research Report on Berberine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Berberine on Cardiometabolic Outcomes Berberine, Placebo - Cardiometabolic Syndrome | Not applicable | Not yet recruiting | University of Central Lancashire | 40 | 2026-07-01 | 2026-04-21 |
| Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort Berberine, Bifidobacterium longum, Bifidobacterium longum and Berberine - Intestinal Discomfort, Abdominal Pain/ Discomfort | Not applicable | Recruiting | Université Catholique de Louvain | 140 | 2026-03-16 | 2026-05-06 |
| Berberine Supplementation, Sprint Interval Training, and Immune Function Study Berberine, Placebo, Sprint Interval Training - Berberine, Sprint Training | Not applicable | Completed | University of Northern Colorado | 40 | 2026-01-01 | 2026-06-05 |
| Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes Metformin, Berberine - Diabetes Mellitis | Not applicable | Not yet recruiting | S.LAB (SOLOWAYS) | 60 | 2025-07-01 | 2025-04-20 |
| A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects. Akkermansia muciniphila, Berberine, Placebo - Prediabetes | Not applicable | Completed | Yu Chen | 110 | 2025-03-12 | 2025-12-22 |
| A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms Berberine - Diabetes Mellitus | Not applicable | Completed | S.LAB (SOLOWAYS) | 40 | 2024-05-03 | 2025-03-07 |
| Berberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and Mechanisms Berberine - Schizophrenia, Negative Symptoms of Schizophrenia | Not applicable | Enrolling by invitation | Tianjin Anding Hospital | 120 | 2023-09-26 | 2026-09-21 |
| Berberine Improving Cognitive Impairments in Schizophrenia Berberine - Schizophrenia Therapeutics | Not applicable | Completed | Tianjin Anding Hospital | 124 | 2023-07-21 | 2026-06-30 |
| Sex Differences in Berberine Pharmacokinetics Berberine - Pharmacokinetic Study in Healthy Volunteers | Not applicable | Completed | University Medicine Greifswald | 30 | 2023-05-05 | 2024-12-20 |
| Treatment Benefits of Berberine Supplementation for Women With PCOS Berberine - Polycystic Ovary Syndrome | Not applicable | Completed | Ayub Teaching Hospital | 120 | 2022-11-01 | 2023-05-18 |
| Effect of Probiotics or Berberine in Hepatic Steatosis Markers, Cardiometabolic and Microbiotic Profile in NAFL. Probiotic, Berberine, Placebo - Non Alcoholic Fatty Liver, Obesity | Not applicable | Unknown | Poznan University of Medical Sciences | 140 | 2022-08-02 | 2022-08-31 |
| Impact of OCT1 and CYP2D6 Genotypes on Pharmacokinetics of Berberine in Healthy Volunteers Berberine - Pharmacokinetic Study in Healthy Volunteers | Not applicable | Completed | University Medicine Greifswald | 42 | 2022-07-19 | 2024-12-24 |
| Nutritional Supplement for Patients With Severe Infection Lauric Acid and Berberine - Severe Infection | Not applicable | Unknown | University of British Columbia | 48 | 2021-10-01 | 2022-11-02 |
| Berberine and Polycystic Ovary Syndrome Berberine - Polycystic Ovary Syndrome, Berberine | Not applicable | Completed | Azienda di Servizi alla Persona di Pavia | 12 | 2020-09-05 | 2021-06-18 |
| Bioavailability of Berberine and Dihydroberberine and Their Impact on Glycemia Berberine, Dihydroberberine 200, Dihydroberberine 100 - Glycemia | Not applicable | Completed | Lindenwood University | 5 | 2020-06-22 | 2021-08-25 |
| Evaluating the Tolerability and Effects of Berberine on Major Metabolic Biomarkers: A Pilot Study Berberine, Identical Placebo - Metabolic Syndrome | Not applicable | Completed | University of Kansas Medical Center | 15 | 2019-08-20 | 2025-04-04 |
| Berberine and Non-Alcoholic Fatty Liver Disease (NAFLD) Berberine - Non-Alcoholic Fatty Liver Disease | Not applicable | Completed | Lida Nejati | 50 | 2018-10-01 | 2019-08-08 |
| The Absorption of Bioactive Berberine in Human Berberine, TPGS emulsified berberine, Quillaja extract emulsified berberine - Healthy | Not applicable | Completed | University of Florida | 32 | 2018-09-25 | 2021-01-27 |
| Gymnema Sylvestre vs Berberine in Obesity Gene Expression of Adipokines Berberine, Gymnema sylvestre - Diabetes Mellitus, Obesity | Not applicable | Completed | National Polytechnic Institute, Mexico | 50 | 2016-02-01 | 2024-05-23 |
| Berberine Treat Metabolic Syndrome in Schizophrenia berberine - Metabolic Syndrome, Female | Not applicable | Completed | Tianjin Anding Hospital | 36 | 2015-01-01 | 2018-04-25 |
Showing 20 of 26. Sign in to see all of them.
Metabolic Syndrome (5) · Schizophrenia (5) · Obesity (4) · Polycystic Ovary Syndrome (4) · Diabetes Mellitus (2) · Non-alcoholic Fatty Liver Disease (2) · Diabetes Mellitus, Type 2 (1) · Dyslipidemias (1) · Infections (1) · Inflammation (1) · Neurobehavioral Manifestations (1) · Prediabetic State (1) · Psychological Well-Being (1)
Tianjin Anding Hospital (5) · Heilongjiang University of Chinese Medicine (2) · S.LAB (SOLOWAYS) (2) · University Medicine Greifswald (2) · Ayub Teaching Hospital (1) · Azienda di Servizi alla Persona di Pavia (1) · Carmel Biosciences (1) · Lida Nejati (1) · Lindenwood University (1) · National Polytechnic Institute, Mexico (1) · Poznan University of Medical Sciences (1) · Rottapharm (1) · University of British Columbia (1) · University of Central Lancashire (1) · University of Florida (1)
China (7) · United States (5) · Germany (2) · Italy (2) · Russia (2) · Belgium (1) · Canada (1) · Iran (1) · Pakistan (1) · Poland (1)
Lihui Hou, MD. (2) · Stefan Engeli, Prof. (2) · Xiaoke Wu, MD.PhD. (2) · Chad Kerksick, PhD (1) · Gary P Wang, MD PhD, FIDSA (1) · James Backes, PharmD (1) · Laurent Simar, Dr (1) · Liwei Gu, PhD (1) · Louise Deldicque, Pr (1) · Serafino Fazio, MD (1) · Syed T Rahman, MD (1) · Sylvie Copine, Dr (1) · Yavuz Yagiz, PhD (1) · Yu Chen, Doctor (1)
PMID 23866924, PMID 24282248, PMID 27769284, PMID 34085287, PMID 35037116, PMID 38074133, PMID 39488825, PMID 39513382