35 completed, 3 terminated, 1 enrolling by invitation, 1 not yet recruiting. 11 Phase 2, 9 Phase 1, 7 Phase 4, 6 Phase 3, 5 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau Neuronavigation-guided single-element focused ultrasound transducer, Lumason, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease, Early Onset | Phase 1 | Not yet recruiting | Columbia University | 6 | 2027-08-01 | 2026-05-13 |
| Alzheimer's Disease Neuroimaging Initiative 4 Neuraceq, Amyvid, Tauvid - Mild Cognitive Impairment, Alzheimer Disease | Enrolling by invitation | University of Southern California | 1500 | 2023-06-09 | 2026-09-29 | |
| Plasma P-tau2017 and Quantitative Amyloid PET Imaging Amyvid - Alzheimer Disease | Phase 1 | Completed | Invicro | 140 | 2021-08-27 | 2025-02-28 |
| Cardiac Uptake of 18F Florbetapir in Patients Undergoing Chemotherapy F18 Florbetapir (amyvid) cardiac PET/CT imaging - Cardiac Amyloidosis | Phase 4 | Terminated | Medical College of Wisconsin | 4 | 2020-10-01 | 2026-07-16 |
| Non-invasive Blood-brain Barrier Opening in Alzheimer's Disease Patients Using Focused Ultrasound Neuronavigation-guided single-element focused ultrasound transducer, Definity, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease | Not applicable | Completed | Columbia University | 6 | 2020-08-06 | 2024-08-26 |
| The Role of F-18 Florbetapir in the Early Detection of Cardiac Amyloidosis F-18 florbetapir - Cardiac Amyloidosis | Phase 4 | Terminated | The Cleveland Clinic | 12 | 2017-01-01 | 2021-07-27 |
| Registry of Amyloid Positive Patients for Alzheimer's Disease Drug Research Trials florbetapir F 18 PET scan - Alzheimer Disease, Cognition Disorders | Completed | Avid Radiopharmaceuticals | 317 | 2016-10-01 | 2018-10-24 | |
| Tau Imaging of Chronic Traumatic Encephalopathy [F18]-T807, [F18]-Florbetapir, MRI/MRS - Chronic Traumatic Encephalopathy | Phase 2 | Completed | Brigham and Women's Hospital | 30 | 2015-01-01 | 2018-05-17 |
| Amyloid and Tauopathy PET Imaging in Acute and Chronic Traumatic Brain Injury Amyvid PET Scan, T807 PET scan - Traumatic Brain Injury, Chronic Traumatic Encephalopathy | Completed | Samuel Gandy | 46 | 2015-01-01 | 2019-05-02 | |
| Quantitative Evaluation of [18F]T807 as a Potential PET Radioligand for Imaging Tau in Patients With Alzheimer's Disease [18F]T807 - Alzheimer's Disease (AD) | Phase 1 | Completed | Molecular NeuroImaging | 16 | 2015-01-01 | 2017-03-08 |
| Evaluation of Electronic Florbetapir (18F) Interpretation Training in Japanese Physicians Florbetapir (18F) - Alzheimer's Disease | Not applicable | Withdrawn | Avid Radiopharmaceuticals | 2014-10-01 | 2014-10-23 | |
| 18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy florbetapir F 18, Flortaucipir F18 - Chronic Traumatic Encephalopathy | Phase 2 | Completed | Avid Radiopharmaceuticals | 41 | 2014-06-01 | 2020-09-07 |
| Imaging Characteristics of a Follow-up 18F-AV-1451 Scan Flortaucipir F18, Florbetapir F 18, Brain PET Scan - Alzheimer's Disease | Phase 2 | Terminated | Avid Radiopharmaceuticals | 44 | 2014-05-01 | 2020-09-07 |
| Florbetapir Calibration to the Centiloid Scale Florbetapir (18F), 11C-PiB - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 35 | 2014-04-01 | 2017-03-09 |
| Evaluation of Reader Training Processes florbetapir F 18 - Alzheimer's Disease | Phase 4 | Completed | Avid Radiopharmaceuticals | 241 | 2014-03-01 | 2015-09-28 |
| The Feasibility of Florbetapir Quantitation in Europe Florbetapir (18F) - Alzheimer's Disease | Phase 4 | Completed | Avid Radiopharmaceuticals | 96 | 2014-03-01 | 2015-07-09 |
| Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects [18F]T807 ([18F]MNI-777) - Alzheimer's Disease (AD), Parkinson's Disease (PD) | Phase 1 | Completed | Molecular NeuroImaging | 16 | 2014-02-01 | 2016-12-16 |
| Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI, and AD Subjects florbetapir F 18, Flortaucipir F18, Brain PET Scan - Alzheimer's Disease | Phase 2 / Phase 3 | Completed | Avid Radiopharmaceuticals | 383 | 2013-12-01 | 2020-09-22 |
| Exploratory Evaluation of Flortaucipir Injection in Healthy Volunteers and Cognitively Impaired Subjects Flortaucipir F18, Brain PET Scan, Whole body PET scan - Alzheimer Disease | Early Phase 1 | Completed | Avid Radiopharmaceuticals | 36 | 2013-08-16 | 2020-09-25 |
| The Feasibility of Florbetapir Quantitation Florbetapir F18 - Alzheimers Disease | Phase 4 | Completed | Avid Radiopharmaceuticals | 96 | 2013-08-01 | 2015-06-29 |
Showing 20 of 41. Sign in to see all of them.
Alzheimer Disease (34) · Cognitive Dysfunction (8) · Chronic Traumatic Encephalopathy (4) · Pick Disease of the Brain (3) · Amyloid Neuropathies, Familial (2) · Cognition Disorders (2) · Neurodegenerative Diseases (2) · Parkinson Disease (2) · Plaque, Amyloid (2) · Tauopathies (2) · Brain Injuries, Traumatic (1) · Dementia (1) · Frontotemporal Dementia (1) · Multiple Sclerosis (1) · Supranuclear Palsy, Progressive (1)
Avid Radiopharmaceuticals (30) · Columbia University (2) · Molecular NeuroImaging (2) · Brigham and Women's Hospital (1) · Institute for Neurodegenerative Disorders (1) · Invicro (1) · Medical College of Wisconsin (1) · Samuel Gandy (1) · The Cleveland Clinic (1) · University of Southern California (1)
United States (32) · Japan (3) · Australia (1) · Canada (1) · France (1) · Italy (1) · Netherlands (1) · United Kingdom (1)
Danna Jennings, MD (3) · Chris Mueller, MD (1) · Dara Dickstein, PhD (1) · David Russell (1) · Elisa Konofagou, PhD (1) · Grace McIlvain, PhD (1) · Martha E. Shenton, Ph.D. (1) · Michael Weiner, MD (1) · Paul Aisen, MD (1) · Ronald Petersen, MD, PHD (1) · Sam Gandy, MD, PhD (1) · Steven Nissen, MD (1) · Wael Jaber, MD (1)
PMID 22749065, PMID 20501908, PMID 21245183, PMID 24716655, PMID 27908967, PMID 30969506, PMID 33587110, PMID 34815790, PMID 37554284, PMID 42467182
R01AG038961 (1), R43NS063607 (1), U19AG024904 (1)