5 not yet recruiting, 5 recruiting, 4 completed, 3 unknown. 18 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Recruiting 5, Completed 4, Not yet recruiting 4, Unknown 3, Suspended 1, Withdrawn 1 |
| Phase 2 | 2 | Not yet recruiting 1, Terminated 1 |
Follow Active taVNS: new trials by email Literature Review of Active taVNS trials Research Report on Active taVNS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transcutaneous Auricular Vagus Nerve Stimulation-Enriched Rehabilitation in Individuals With Lipedema Active taVNS, Sham taVNS, Aerobic Exercise - Lipedema | Not applicable | Recruiting | Istanbul University - Cerrahpasa | 30 | 2026-09-18 | 2026-10-05 |
| taVNS for Letter Learning in Dyslexia active taVNS, sham taVNS - Dyslexia | Not applicable | Suspended | University of Florida | 100 | 2026-09-01 | 2026-05-28 |
| How Does Vagus Nerve Stimulation Affect Blood Glucose, Food, and Movement Cravings? Active taVNS, Sham taVNS - Vagus Nerve Stimulation | Not applicable | Withdrawn | University of Minnesota | 2026-09-01 | 2026-07-20 | |
| Non-Invasive Transcutaneous Auricular Vagus Nerve Stimulation Applied at Different Durations in Healthy Adults Active taVNS, Sham stimulation - Healthy Volunteers | Not applicable | Not yet recruiting | Sinop University | 44 | 2026-05-01 | 2026-04-15 |
| Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery Active taVNS, Sham taVNS Group - Postoperative Delirium (POD), Postoperative | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 270 | 2026-02-28 | 2026-03-17 |
| Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Breast Cancer Surgery Patients Active taVNS, Sham taVNS - Depression, Postoperative | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 232 | 2026-02-28 | 2026-03-09 |
| taVNS for Breast Cancer Pain and Symptom Management Active taVNS, Sham taVNS - Breast Cancer Survivors | Not applicable | Recruiting | Florida State University | 40 | 2026-02-24 | 2026-03-30 |
| taVNS on Functional Mobility in People With DP Active taVNS, Sham taVNS - PARKINSON DISEASE (Disorder) | Phase 2 | Not yet recruiting | Universidade Federal de Pernambuco | 30 | 2026-02-15 | 2026-01-26 |
| Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences Active taVNS, Sham Stimulation - Cognitive Assessment, Cognition | Not applicable | Not yet recruiting | Bahçeşehir University | 60 | 2025-12-01 | 2025-12-01 |
| Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Chronic Kidney Disease (CKD) Active taVNS, Sham taVNS - Chronic Kidney Diseases | Not applicable | Recruiting | NYU Langone Health | 30 | 2025-10-15 | 2026-10-29 |
| Efficacy of Trans-auricular Vagus Nerve Stimulation on Upper Extremity Motor Recovery in Stroke Survivors Active taVNS, Sham taVNS - Stroke | Not applicable | Recruiting | Universidade Federal de Pernambuco | 30 | 2025-08-01 | 2026-05-04 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms Active taVNS, Sham taVNS - Persistent Post-concussive Symptoms | Not applicable | Recruiting | University of Liege | 48 | 2025-05-28 | 2025-06-12 |
| Effect of taVNS on Heart Rate in Persistent Atrial Fibrillation active taVNS, sham-taVNS - Atrial Fibrillation, Persistent | Not applicable | Unknown | Burrell College of Health Sciences | 30 | 2023-08-07 | 2023-07-14 |
| Transcutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury active taVNS, sham taVNS - Spinal Cord Injuries, Spinal Cord Diseases | Not applicable | Unknown | Possover International Medical Center AG | 10 | 2023-07-01 | 2023-05-17 |
| Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA Active tcVNS, Sham tcVNS - Juvenile Idiopathic Arthritis (JIA) | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 18 | 2023-06-27 | 2025-11-25 |
| BabyStrong Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Paired Bottle Feeding to Improve Oral Feeding transcutaneous auricular vagus nerve stimulation, Sham transcutaneous auricular vagus nerve stimulation - Infant Feeding Problems, taVNS | Not applicable | Completed | Medical University of South Carolina | 17 | 2022-08-01 | 2025-10-28 |
| Augmenting Standard-of-care Treatment of Plaque Psoriasis by Neuromodulation Active taVNS, Sham taVNS - Psoriasis Vulgaris | Not applicable | Unknown | Burrell College of Health Sciences | 50 | 2022-04-26 | 2023-07-10 |
| Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness Active taVNS, sham taVNS - Consciousness Disorder, Minimally Conscious State | Not applicable | Completed | University of Liege | 44 | 2022-02-09 | 2026-05-01 |
| taVNS Cold Pressor Active taVNS, Sham taVNS - taVNS, Brain Stimulation | Not applicable | Completed | Medical University of South Carolina | 24 | 2021-10-01 | 2024-01-17 |
| taVNS in Mild to Moderate Parkinson's Disease Active taVNS, Sham Stimulation - Parkinson Disease | Not applicable | Completed | Medical University of South Carolina | 33 | 2018-03-20 | 2023-01-25 |
Anxiety Disorders (2) · Depression (2) · Inflammation (2) · Pain (2) · Parkinson Disease (2) · Arthritis, Juvenile (1) · Atrial Fibrillation (1) · Central Nervous System Diseases (1) · Consciousness Disorders (1) · Dyslexia (1) · Emergence Delirium (1) · Lipedema (1) · Movement Disorders (1) · Nervous System Diseases (1) · Persistent Vegetative State (1)
Medical University of South Carolina (3) · Burrell College of Health Sciences (2) · Chinese PLA General Hospital (2) · Universidade Federal de Pernambuco (2) · University of Liege (2) · Bahçeşehir University (1) · Florida State University (1) · Istanbul University - Cerrahpasa (1) · NYU Langone Health (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Possover International Medical Center AG (1) · Sinop University (1) · University of Florida (1) · University of Minnesota (1)
United States (10) · Belgium (2) · Brazil (2) · China (2) · Turkey (Türkiye) (2)
Harald M Stauss, MD, PhD (2) · Ali Veysel Ozden (1) · Aurore Thibaut, PT, PhD (1) · Aurore Thibaut, PhD (1) · Beth Gottlieb, MD (1) · Betty Diamond, MD (1) · Christopher W Austelle, MD (1) · Cynthia Aranow, MD (1) · Marc MP Possover, MD, PhD (1) · Mark Hartman, PhD (1) · Nicolas Lejeune, MD, PhD (1) · Qandeel Soomro, MD (1) · Timir Datta-Chaudhuri, PhD (1)
K23DK139462 (1), R25DA020537 (1), R41HD104409 (1)