26 completed, 18 unknown, 4 not yet recruiting, 3 recruiting. 35 Not applicable, 7 Phase 2, 4 Phase 4, 3 Early Phase 1, 3 Phase 1.
Follow White Spot Lesion: new trials by email Literature Review of White Spot Lesion trials Research Report on White Spot Lesion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remineralization Potential of Bioactive Varnish S-PRG barrier coat, Profluorid Varnish - White Spot Lesion | Not applicable | Not yet recruiting | Future University in Egypt | 60 | 2026-06-01 | 2026-05-22 |
| Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets Transbond™ XT bonding procedure, GC Ortho Connect™ bonding procedure - Tooth Demineralization, White Spot Lesion | Not applicable | Not yet recruiting | University Hospital, Montpellier | 34 | 2026-01-01 | 2026-01-21 |
| Remineralization Effect Of Egg Shell Versus Fluoride Varnish On Early Carious White Spot Lesions In Primary Teeth Egg shell hydrogel, Fluoride varnish - White Spot Lesion | Phase 2 | Not yet recruiting | Cairo University | 66 | 2025-09-01 | 2025-05-15 |
| PREVALENCE OF WHITE SPOT LESIONS IN ENAMEL AFTER ORTHODONTIC TREATMENT IN YOUNG ADULTS orthodontic treatment - White Spot Lesion | Not yet recruiting | Cairo University | 368 | 2025-08-01 | 2025-03-18 | |
| The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled Split-Mouth Study White spot lesion with fluoride varnish application, White spot lesion without fluoride varnish application - White Spot Lesion | Not applicable | Active not recruiting | Mansoura University | 25 | 2025-06-25 | 2026-01-06 |
| Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions P11-4, a self-assembling peptide, P11-4, a self-assembling peptide with flouride, resin infilteration - White Spot Lesion | Early Phase 1 | Recruiting | October 6 University | 150 | 2024-08-30 | 2024-11-27 |
| The Remineralization of Early Enamel Caries in Permanent Teeth self assembling peptide p11-4 with fluoride, 5% sodium fluoride varnish - White Spot Lesion | Phase 1 | Unknown | Tanta University | 50 | 2024-06-06 | 2024-05-23 |
| The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients Photodynamic therapy, Tricalcium phosphate (TCP) varnish with 5% NaF, Chlorhexidine varnish - Plaque, Dental, Dental Plaque Induced Gingivitis | Not applicable | Unknown | University of Zagreb | 50 | 2024-05-01 | 2024-03-26 |
| A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification - Dental Caries, White Spot Lesion | Phase 4 | Recruiting | Dow University of Health Sciences | 90 | 2023-12-12 | 2025-03-11 |
| White Spot Lesions Treatment in Orthodontic 5% sodium fluoride, Intensive 5% sodium fluoride, Casein Phosphopeptide-Amorphous Calcium Phosphate - White Spot Lesion | Phase 4 | Unknown | Riyadh Elm University | 88 | 2023-10-01 | 2023-09-25 |
| Air-polishing With Erythritol During Orthodontic Tretament Ultrasonic scaler, Air-Flow Prophylaxis Master - Inflammation Gum, White Spot Lesion | Not applicable | Recruiting | Catherine Giannopoulou | 60 | 2023-09-11 | 2026-05-05 |
| İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin sws grade 1, sws grade 2, control - Duodenal Diseases, White Spot Lesion | Not applicable | Completed | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 93 | 2023-09-01 | 2024-01-10 |
| Effectiveness of Different Remineralizing Strategies on the Management of Early Carious Lesions in Primary Teeth self assmbling peptide p11-4 combined with 0.05% fluoride, Casein phosphopeptide amorphous calcium phosphate, 5% sodium fluoride varnish - White Spot Lesion | Early Phase 1 | Completed | Alexandria University | 66 | 2023-08-15 | 2025-01-29 |
| The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients Fluoride varnsh, Normal saline - White Spot Lesion | Not applicable | Unknown | King Abdullah University Hospital | 44 | 2023-06-01 | 2024-05-07 |
| Effect of Different Remineralization Gels Remineralization gel - White Spot Lesion | Not applicable | Unknown | Marmara University | 45 | 2023-05-24 | 2023-05-22 |
| Clinical Evaluation of an Experimental Remineralization Product Experimental Fluoride Application - White Spot Lesion | Not applicable | Completed | Ivoclar Vivadent AG | 43 | 2023-03-28 | 2026-03-27 |
| Evaluation of Two Varnishes on the Improvement of White Spot Lesions in Children giomer varnish - White Spot Lesion | Not applicable | Completed | October University for Modern Sciences and Arts | 22 | 2023-03-15 | 2024-04-04 |
| Efficacy Evaluation of Two Different Fluoride Applications Fluoride Application (Experimental Fluoride Application), Fluor Protector S - White Spot Lesion | Not applicable | Completed | Ivoclar Vivadent AG | 23 | 2023-02-24 | 2025-10-23 |
| Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions Curodont repair Self- assembling peptide P11-4, Ph-chi phosphorylated - nano-chitosan, CCP-ACP " +ve control " Casein phosphopeptide amorphous calcium phosphate - White Spot Lesion | Not applicable | Unknown | Hams Hamed Abdelrahman | 63 | 2023-01-01 | 2022-10-18 |
| Effect of Poly Amido Amine Dendrimer, Nano-hydroxyapatite Poly(Amidoamine) dendrimer - White Spot Lesion | Phase 1 | Completed | Egymedicalpedia | 45 | 2022-06-01 | 2023-03-16 |
Showing 20 of 53. Sign in to see all of them.
Dental Caries (5) · Dental Plaque (3) · Gingivitis (2) · Tooth Demineralization (2) · Dental Enamel Hypomineralization (1) · Duodenal Diseases (1)
Stomatognathic Diseases (11) · Tooth Diseases (9) · Tooth Demineralization (4) · Dental Deposits (3) · Gingival Diseases (2) · Infections (2) · Mouth Diseases (2) · Periodontal Diseases (2) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Developmental Defects of Enamel (1) · Digestive System Diseases (1) · Gastrointestinal Diseases (1) · Intestinal Diseases (1) · Stomatognathic System Abnormalities (1)
casein phosphopeptide-amorphous calcium phosphate nanocomplex (4) · Fluorides (3) · Bifluorid 12 (2) · Duraflor (2) · Fluoride Treatment (2) · Orthodontics (2) · PRG Barrier Coat (2) · Paint (2) · sodium fluoride topical preparation (2) · tricalcium phosphate (2) · Behavior Therapy (1) · Congresses as Topic (1) · Control Groups (1) · Dendrimers (1) · GC dentin cement (1)
Cairo University (9) · Hams Hamed Abdelrahman (3) · Jordan University of Science and Technology (3) · Al-Azhar University (2) · Ivoclar Vivadent AG (2) · University of Alabama at Birmingham (2) · Alexandria University (1) · Benha University (1) · Catherine Giannopoulou (1) · Damascus University (1) · Dow University of Health Sciences (1) · Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital (1) · Egymedicalpedia (1) · Federal University of Paraíba (1) · Future University in Egypt (1)
Egypt (15) · Turkey (Türkiye) (4) · Jordan (3) · United States (3) · Saudi Arabia (2) · Belgium (1) · Brazil (1) · France (1) · Hong Kong (1) · Italy (1) · Mexico (1) · Pakistan (1) · Poland (1) · Romania (1) · Spain (1)
Chung H Kau, BDS, PhD (2) · Susan Al-Khateeb (2) · Ada Delean, Prof. Dr. (1) · Ahmed H. Samaha, BSc (1) · Ahmed I Mekky, BDS (1) · Andrea Scribante, DDS, PhD. (1) · Brad Herman, DDS (1) · Cynthia KY Yiu, MDS, PhD (1) · Dalia AM Talaat, PhD (1) · Deseyne Thomas (1) · Dorota Olczak-Kowalczyk, Professor (1) · Dr Saba Arshad (1)
PMID 30719933, PMID 16265432, PMID 17026510, PMID 18305389, PMID 19906109, PMID 22260755, PMID 25126675, PMID 26418918, PMID 27007355, PMID 30071781, PMID 32354432, PMID 33009565, PMID 33706305, PMID 35886524, PMID 37598194, PMID 38388987, PMID 41091662, PMID 41412271, PMID 5264376, PMID 8181546