3 completed, 3 recruiting, 2 unknown, 1 withdrawn. 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 1 | Withdrawn 1 |
Follow White Matter Disease: new trials by email Literature Review of White Matter Disease trials Research Report on White Matter Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Natural History Study of Patients with HPDL Mutations Patient Registry, Dry blood spots sampling - Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia | Recruiting | University of California, San Diego | 50 | 2023-05-18 | 2025-03-30 | |
| Evaluation of Brain Waste Clearance Pathways Using Magnetic Resonance Imaging in Pediatric Patients With White Matter Diseases Magnetic resonance imaging - Glymphatic System, White Matter Disease | Unknown | IRCCS Eugenio Medea | 100 | 2022-03-01 | 2024-03-28 | |
| Assessment of the Impact of Gadolinium Injection on the Measurement of the QSM Signal MRI - White Matter Disease | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 73 | 2022-01-21 | 2026-01-05 | |
| Brain Networks and Mobility Function: B-NET Central Nervous System, White Matter Disease | Completed | Wake Forest University Health Sciences | 192 | 2018-07-20 | 2023-08-18 | |
| The Relationship Between Right-to-left Shunt and Brain White Matter Lesions in Patients With Migraine White Matter Disease, Right-to-left Shunt | Unknown | The First Hospital of Jilin University | 1500 | 2018-06-15 | 2020-07-23 | |
| Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) Leukoencephalopathies, LBSL | Recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 100 | 2018-04-01 | 2024-07-03 | |
| LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies Leukodystrophy, White Matter Disease | Completed | Children's Hospital of Philadelphia | 236 | 2017-01-06 | 2025-11-10 | |
| The Myelin Disorders Biorepository Project Leukodystrophy, White Matter Disease | Recruiting | Children's Hospital of Philadelphia | 12000 | 2016-12-08 | 2025-10-23 |
Leukoencephalopathies (9) · Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (3) · Adrenoleukodystrophy (2) · Aicardi-Goutieres syndrome (2) · Alexander Disease (2) · Alexanders leukodystrophy (2) · Allan-Herndon-Dudley syndrome (2) · Attention Deficit Disorder with Hyperactivity (2) · CADASIL (2) · Canavan Disease (2) · Charcot-Marie-Tooth Disease (2) · Cockayne Syndrome (2) · Gangliosidoses (2) · Gangliosidoses, GM2 (2) · Genetic Diseases, Inborn (2)
Brain Diseases (9) · Central Nervous System Diseases (9) · Nervous System Diseases (9) · Pathological Conditions, Signs and Symptoms (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Neurologic Manifestations (4) · Brain Diseases, Metabolic (3) · Brain Ischemia (3) · Cardiovascular Diseases (3) · Cerebrovascular Disorders (3) · Congenital Abnormalities (3) · Hereditary Sensory and Motor Neuropathy (3) · Heredodegenerative Disorders, Nervous System (3) · Infant, Newborn, Diseases (3) · Metabolic Diseases (3)
Magnetic Resonance Imaging (1)
Children's Hospital of Philadelphia (2) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (1) · IRCCS Eugenio Medea (1) · MGAM LLC (1) · The First Hospital of Jilin University (1) · University of California, San Diego (1) · Wake Forest University Health Sciences (1)
United States (5) · China (1) · France (1) · Italy (1)
Adeline Vanderver, MD (2) · Amena S Fine, MD PhD (1) · Joseph Gleeson (1) · Sibo Wang, MD,PhD (1) · Stephen Kritchevsky, PhD (1) · Yi Yang, MD,PhD (1) · Yingqi Xing, MD,PhD (1) · Yongsheng Gao, MD (1)
PMID 18294247, PMID 21259015, PMID 23867200, PMID 28123166, PMID 30353860, PMID 32342562, PMID 32550142, PMID 32749716, PMID 33014733, PMID 40368591
R01AG052419 (1), U01NS106845 (1), U54NS115052 (1)