8 completed, 4 recruiting, 2 unknown, 1 not yet recruiting. 6 Phase 2, 5 Not applicable, 3 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Recruiting 3, Completed 1, Not yet recruiting 1, Terminated 1 |
| Not applicable | 5 | Completed 4, Recruiting 1 |
| Phase 4 | 3 | Unknown 2, Completed 1 |
| Phase 1 | 1 | Terminated 1 |
Follow Venous Malformation: new trials by email Literature Review of Venous Malformation trials Research Report on Venous Malformation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies Everolimus - Vascular Malformations, Arteriovenous Malformations | Phase 2 | Not yet recruiting | Yonsei University | 67 | 2026-04-01 | 2026-03-17 |
| Intralesional Bleomycin Sclerotherapy for Low-Flow Vascular Malformations of the Head and Neck Bleomycin (Bleocel 15) - Vascular Malformations, Venous Malformation | Phase 4 | Completed | University Of Anbar | 20 | 2025-08-25 | 2026-07-27 |
| A Study of Enalapril in Treatment of Venous Malformations Enalapril - Venous Malformation, Pain | Phase 2 | Recruiting | Oslo University Hospital | 12 | 2025-02-01 | 2025-04-02 |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS) national registry - PIK3CA-related Overgrowth Spectrum, CLOVES Syndrome | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 28 | 2023-02-21 | 2026-02-23 | |
| Efficacy and Safety Analysis of Polylauric Alcohol More Stable Foam Versus Ordinary Foam in the Treatment of Head and Neck Venous Malformations The addition of sodium hyaluronate to poly (cinnamyl alcohol-RRB- produces a more stable foam - Venous Malformation | Not applicable | Recruiting | Qilu Hospital of Shandong University | 110 | 2022-06-01 | 2025-07-15 |
| Weekly Sirolimus Therapy Sirolimus - Venous Malformation, Lymphatic Malformation | Phase 2 | Recruiting | Medical University of South Carolina | 24 | 2022-01-18 | 2026-03-05 |
| Vascular Anomaly Pathology and Genomics Biopsy Study Percutaneous Vascular Anomaly/Malformation Biopsy - Vascular Malformations, Vascular Anomaly | Not applicable | Completed | Mayo Clinic | 3 | 2021-04-06 | 2022-04-21 |
| Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation Trametinib tablet - Venous Malformation, Arterial Disease | Phase 2 | Completed | Stanford University | 25 | 2020-12-01 | 2026-04-24 |
| First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations VT30 - Venous Malformation, Lymphatic Malformation | Phase 1 / Phase 2 | Terminated | Venthera, Inc., a BridgeBio company | 15 | 2020-10-01 | 2022-08-04 |
| Electromagnetic Navigation During Ultrasound Guided Foam Sclerotherapy for Venous Malformations Electromagnetic Navigation - Venous Malformation | Not applicable | Completed | University Hospital, Toulouse | 30 | 2020-07-15 | 2023-02-22 |
| Complications of Ethanol-amine Oleate Intralesional Sclerotherapy Ethanol-amine Oleate Sclerotherapy Injection - Venous Malformation | Completed | Suez Canal University | 15 | 2019-02-28 | 2026-05-13 | |
| Treatment of Venous Malformation Direct Puncture Repair / Ethanol, Direct Puncture Repair / Polidocanol - Venous Malformation | Not applicable | Completed | Al-Azhar University | 20 | 2018-10-01 | 2022-10-19 |
| Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformation Rapamycin - Blue Rubber Bleb Nevus Syndrome, Venous Malformation | Phase 4 | Unknown | Peking Union Medical College Hospital | 20 | 2018-07-31 | 2018-12-19 |
| Influence of Flat-knitted Compression Stockings Class I and II on Venous Malformations compression stockings class I, compression stockings class II - Vascular Malformations, Vascular Malformation Peripheral | Not applicable | Completed | University Hospital Erlangen | 18 | 2017-10-01 | 2021-03-16 |
| Compare Two Different Sclerosing Agents in the Treatment of Venous Malformations Bleomycin, Fibrovein, Bleomycin + Fibrovein - Venous Malformation | Phase 4 | Unknown | Oslo University Hospital | 135 | 2011-08-01 | 2023-11-07 |
Vascular Malformations (7) · Lymphatic Abnormalities (6) · Arteriovenous Malformations (3) · Hemangioma (2) · Hereditary Sensory and Autonomic Neuropathies (2) · Klippel-Trenaunay-Weber Syndrome (2) · Lymphangioma (2) · Blue rubber bleb nevus syndrome (1) · Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi (1) · Hemangioendothelioma (1) · Lymphangioma, Cystic (1) · Megalencephaly (1) · Megalodactyly (1) · Nevus (1) · Pain (1)
Congenital Abnormalities (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Cardiovascular Abnormalities (7) · Cardiovascular Diseases (7) · Hemic and Lymphatic Diseases (6) · Lymphatic Diseases (6) · Vascular Diseases (4) · Neoplasms (3) · Neoplasms by Histologic Type (3) · Angiomatosis (2) · Genetic Diseases, Inborn (2) · Heredodegenerative Disorders, Nervous System (2) · Neoplasm, Lymphatic Tissue (2) · Neoplasms, Vascular Tissue (2) · Nervous System Diseases (2)
Bleomycin (2) · Ethanol (2) · Sirolimus (2) · Alpelisib (1) · Enalapril (1) · Everolimus (1) · Polidocanol (1) · Sclerotherapy (1) · mirdametinib (1) · trametinib (1)
Oslo University Hospital (2) · Al-Azhar University (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Mayo Clinic (1) · Medical University of South Carolina (1) · Murdoch Childrens Research Institute (1) · Peking Union Medical College Hospital (1) · Qilu Hospital of Shandong University (1) · Stanford University (1) · Suez Canal University (1) · University Hospital Erlangen (1) · University Hospital, Toulouse (1) · University Of Anbar (1) · Venthera, Inc., a BridgeBio company (1) · Yonsei University (1)
United States (4) · China (2) · Egypt (2) · France (2) · Norway (2) · Australia (1) · Germany (1) · Iraq (1)
Andreas Abildgaard, Phd (1) · Chelsea Shope, MSCR (1) · David A Woodrum, MD, PhD (1) · Emily Bendel, MD (1) · Guillaume Canaud, MD,PHD (1) · Joyce Teng, MD, PhD, FAAD (1) · Lydia Pathmanathan, MBBS, FRACP. (1) · Michael Henderson (1) · Sarah Arafat, MSc (1) · Stephen Luen, MBChB, FRACP. (1) · Tony Penington, MBBS, FRACS. (1) · Wassim Mokaddem, MD (1)
PMID 28431241, PMID 29899452, PMID 40148035
2023 (1)