37 completed, 12 recruiting, 8 unknown, 4 active not recruiting. 23 Phase 2, 12 Phase 1, 6 Not applicable, 6 Phase 3, 2 Phase 4.
Follow Neoplasm, Lymphatic Tissue: new trials by email Literature Review of Neoplasm, Lymphatic Tissue trials Research Report on Neoplasm, Lymphatic Tissue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies Everolimus - Vascular Malformations, Arteriovenous Malformations | Phase 2 | Not yet recruiting | Yonsei University | 67 | 2026-04-01 | 2026-03-17 |
| Radiological Diagnosis of Pediatric Neck Swellings Lipoma, Branchial Cleft Anomalies | Active not recruiting | Sohag University | 50 | 2026-02-20 | 2026-07-30 | |
| Evaluating the Long-term Safety and Tolerability of Imatinib in Patients With Lymphangioleiomyomatosis (LAM) Imatimib Mesylate, Placebo - Lymphangioleiomyomatosis (LAM), Lymphangioleiomyomatosis | Phase 1 | Recruiting | Columbia University | 20 | 2025-10-20 | 2026-01-21 |
| Role of Extracellular Vesicles as Biomarkers of Pulmonary Involvement in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex Pulmonary Function Test, Analysis of Extracellular Vesicles - Lymphangioleiomyomatosis (LAM), Extracellular Vesicles; Generation and Function | Recruiting | University of Milan | 80 | 2025-04-16 | 2025-12-26 | |
| A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations Alpelisib, Mirdametinib - Slow-Flow Vascular Malformation, Fast-Flow Vascular Malformation | Phase 2 | Recruiting | Murdoch Childrens Research Institute | 50 | 2024-09-13 | 2026-05-05 |
| Bleomycin Intralesional Injections of Cystic Hygromas Intralesional Injections - Lymphatic Malformations | Not applicable | Completed | Delta University for Science and Technology | 30 | 2024-09-01 | 2026-04-28 |
| Ultraspound-guided Intralesional Injection of Cystic Hygroma - A Case Report Intralesional Injection of Bleomycin - Intralesional Injection of Cystic Hygroma, Cystic Hygroma (Macro-cystic Lymphatic Malformation) | Not applicable | Completed | Delta University for Science and Technology | 1 | 2024-09-01 | 2026-04-30 |
| SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations QTORIN 3.9% Rapamycin Anhydrous Gel - Microcystic Lymphatic Malformation | Phase 3 | Active not recruiting | Palvella Therapeutics, Inc. | 51 | 2024-07-31 | 2026-03-27 |
| Institution of an Italian Registry and Biobank for Biological Sample Collection Genetic profiling of all eligible patients - Lymphatic Malformation, Lymphatic Abnormality | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 70 | 2024-06-27 | 2025-03-25 |
| The Genotype and Phenotype of Lymphangioleiomyomatosis Sporadic Lymphangioleiomyomatosis, TSC-associated Lymphangioleiomyomatosis | Recruiting | National Taiwan University Hospital | 100 | 2024-05-10 | 2024-05-09 | |
| Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. Alpelisib, Placebo - Lymphatic Malformations | Phase 2 / Phase 3 | Recruiting | Novartis Pharmaceuticals | 232 | 2023-11-24 | 2026-10-09 |
| Role of Sirolimus in Treatment of Microcystic , Mixed Lymphatic and Vascular Malformations Sirolimus 1Mg Oral Tablet - Microcystic Lymphatic Malformation, Combined Vascular Malformation | Unknown | Sohag University | 10 | 2023-11-20 | 2023-12-15 | |
| Tuberous Sclerosis Complex and Lymphangioleiomyomatosis Pregnancy Registry (TSC-LAM Registry) Tuberous Sclerosis Complex, Lymphangioleiomyomatosis | Recruiting | David M. Ritter | 300 | 2023-07-01 | 2026-01-23 | |
| Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases Breath test using the Compact PTR-TOF-MS, Portable cardiac monitor "CardioQvark", Assessment of arterial stiffness using the VaSera VS-1500N - Chronic Respiratory Diseases, Cystic Fibrosis | Enrolling by invitation | I.M. Sechenov First Moscow State Medical University | 400 | 2023-01-30 | 2024-07-30 | |
| Lymphangioleiomyomatosis, a Study on Cathepsin K 24h urine, urine sample - Lymphangioleiomyomatosis, Tuberous Sclerosis Complex | Completed | University Hospital, Tours | 19 | 2022-05-31 | 2023-03-29 | |
| Study Evaluating the Safety and Efficacy of PTX-022 (QTORIN Sirolimus) in the Treatment of Microcystic Lymphatic Malformations PTX-022 - Microcystic Lymphatic Malformation | Phase 2 | Completed | Palvella Therapeutics, Inc. | 12 | 2022-01-13 | 2025-01-17 |
| Characterizing LAM With 11C-Choline PET/CT 11C-Choline - Lymphangioleiomyomatosis | Early Phase 1 | Unknown | Peking Union Medical College Hospital | 50 | 2021-11-01 | 2021-10-21 |
| Effect of Loratadine in Lymphangioleiomyomatosis Loratadine, Placebo 10mg/day added to rapamycin for 12 months - Lymphangioleiomyomatosis | Phase 2 | Unknown | Institut d'Investigació Biomèdica de Bellvitge | 62 | 2021-11-01 | 2022-01-27 |
| Feasibility of [11C]Acetate-PET in LAM and TSC [11C]acetate - Lymphangioleiomyomatosis, Tuberous Sclerosis Complex | Phase 1 / Phase 2 | Active not recruiting | Brigham and Women's Hospital | 7 | 2021-08-30 | 2026-01-21 |
| Sleep Patterns in Patients Affected by Lymphangioleiomiomatosis LAM patients underwent PSG - Lymphangioleiomyomatosis, Sleep Disorder | Not applicable | Unknown | dr. Stefano Nava | 15 | 2020-06-30 | 2021-03-18 |
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Lymphangioleiomyomatosis (48) · Tuberous Sclerosis (16) · Lymphangioma (13) · Lymphatic Abnormalities (9) · Lymphangioma, Cystic (6) · Angiomyolipoma (5) · Vascular Malformations (5) · Lung Diseases (3) · Sarcoma (3) · Arteriovenous Malformations (2) · Ascites (2) · Asthma (2) · Astrocytoma (2) · Breast Neoplasms (2) · Fibrosarcoma (2)
Neoplasms by Histologic Type (66) · Neoplasms (64) · Hemic and Lymphatic Diseases (60) · Lymphatic Diseases (59) · Neoplasms, Connective and Soft Tissue (51) · Immune System Diseases (48) · Immunoproliferative Disorders (48) · Lymphoproliferative Disorders (48) · Perivascular Epithelioid Cell Neoplasms (47) · Lymphangiomyoma (46) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (30) · Congenital Abnormalities (26) · Nervous System Diseases (19) · Genetic Diseases, Inborn (18)
Sirolimus (12) · Everolimus (7) · Alpelisib (3) · Imatinib Mesylate (2) · Bevacizumab (1) · Celecoxib (1) · Cetuximab (1) · Disulfides (1) · Doxycycline (1) · Fluorouracil (1) · Genetic Testing (1) · Glutamine (1) · Hydroxychloroquine (1) · Immunoglobulin G (1) · Injections, Intralesional (1)
National Heart, Lung, and Blood Institute (NHLBI) (8) · University of Cincinnati (5) · Novartis Pharmaceuticals (4) · Brigham and Women's Hospital (3) · Children's Hospital Medical Center, Cincinnati (2) · Delta University for Science and Technology (2) · Palvella Therapeutics, Inc. (2) · Peking Union Medical College Hospital (2) · Sohag University (2) · Yonsei University (2) · CENTOGENE GmbH Rostock (1) · Cardiff University (1) · Columbia University (1) · David M. Ritter (1) · Denise Martin Adams (1)
United States (35) · France (7) · Italy (7) · Egypt (5) · China (4) · United Kingdom (4) · Canada (3) · Germany (3) · Spain (3) · Australia (2) · Brazil (2) · Japan (2) · Netherlands (2) · Poland (2) · Russia (2)
Joel Moss, M.D. (4) · Francis X McCormack, MD (3) · Frank McCormack, MD (2) · Vincent Cottin, MD (2) · Alfred T Lane, MD (1) · Angelo M Taveira-DaSilva, M.D. (1) · Carlos RR Carvalho, PhD (1) · Carlos Roberto Ribeiro Carvalho, MD, PhD (1) · Carmen P Priolo, MD PhD (1) · Chiara Leoni (1) · Christopher Meinberg (1) · David J Kwiatkowski, MD PhD (1) · David M Ritter, MD, PhD (1) · Denise M Adams, MD (1)
PMID 21410393, PMID 11527161, PMID 12172553, PMID 16418953, PMID 18184959, PMID 19117316, PMID 19407619, PMID 20843632, PMID 21180274, PMID 21482669, PMID 21525172, PMID 24159565, PMID 24556663, PMID 24591665, PMID 24656411, PMID 25682445, PMID 25979023, PMID 26113676, PMID 26156073, PMID 26799509, PMID 26917604, PMID 26933802, PMID 28192114, PMID 28570161, PMID 29023494, PMID 29456959, PMID 29928081, PMID 30053159, PMID 30144422, PMID 30192751, PMID 30291925, PMID 30672136, PMID 30846465, PMID 31299246, PMID 32060062, PMID 32139985, PMID 32962746, PMID 33059994, PMID 33549601, PMID 33625132, PMID 35787784, PMID 35852876, PMID 36642366, PMID 36801466, PMID 36927115, PMID 36930738, PMID 37311055, PMID 39044220, PMID 39148107, PMID 39489895
1ZIAHL002541-21 (1), 2008 (1), 2023 (1), R21CA103486 (1), R34HL138235 (1), U01HL058440 (1), U01HL131755 (1), U54HL127672 (1), U54RR019498 (1), UL1TR000093 (1)