70 completed, 28 unknown, 5 withdrawn, 4 not yet recruiting. 49 Not applicable, 21 Phase 1, 9 Phase 3, 8 Phase 4, 7 Phase 2.
Follow Type2 Diabetes Mellitus: new trials by email Literature Review of Type2 Diabetes Mellitus trials Research Report on Type2 Diabetes Mellitus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2) aleniglipron, Placebo - Obesity, Overweight | Phase 3 | Recruiting | Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics | 1100 | 2026-07-17 | 2026-10-20 |
| A Study of ONO-3310 in Healthy Adult Male Subjects and Chronic Kidney Disease Patients With Type 2 Diabetes Mellitus ONO-3310, Placebo - Type2 Diabetes Mellitus, Chronic Kidney Disease | Phase 1 | Recruiting | Ono Pharmaceutical Co., Ltd. | 120 | 2026-06-02 | 2026-06-08 |
| SnapDandCGMinType2DM SnapD, Linx CGM, Diabetes Self-Management Education (DSMES) - Type2 Diabetes Mellitus | Not applicable | Recruiting | Ramathibodi Hospital | 45 | 2026-01-20 | 2026-08-13 |
| "Effect of Omega-3 Supplementation as Add on Therapy on Glycemic Control and Lipid Profile in Type2 Diabetes Mellitus." Omega-3 Fatty Acids, placebo - Type2 Diabetes Mellitus | Not applicable | Enrolling by invitation | Bangladesh Medical University | 66 | 2026-01-01 | 2026-01-21 |
| INcreasing the Uptake of DSMES Program and Addressing Social Needs in Low-Income VulneRablE Immigrants CHW-enabled CCL, Mobile health (mHealth) diabetes self-management education and support (DSMES) videos - Type2 Diabetes Mellitus | Not applicable | Not yet recruiting | NYU Langone Health | 480 | 2026-01-01 | 2025-12-22 |
| Diet and Progression of CKD in Patients With Type 2 Diabetes Mellitus CKD Stage 1-4, Diet Pattern Analysis | Not yet recruiting | Mariam Emeel Haleem Naseem | 160 | 2025-10-01 | 2025-09-12 | |
| Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT) Initiation of tirzepatide, Initiation of sitagliptin - Type2 Diabetes Mellitus, Atherosclerotic Cardiovascular Disease | Completed | Brigham and Women's Hospital | 49065 | 2025-09-19 | 2026-04-30 | |
| Clinical Study to Assess the Safety, Efficacy and In-Use Tolerability of Herbal-Based Sugar Support Effervescent Tablets in Type-2 Diabetes Mellitus Patients Sugar support effervescent Tablets - Type2 Diabetes Mellitus | Not applicable | Completed | NovoBliss Research Pvt Ltd | 14 | 2025-08-25 | 2026-08-06 |
| A Study to Evaluate the Safety and Pharmacokinetics of Dapagliflozin, Linagliptin, and Metformin in Healthy Adults Comparator 1, Comparator 2, Test Drug - Type2 Diabetes Mellitus | Phase 1 | Not yet recruiting | AJU Pharm Co., Ltd. | 50 | 2025-08-01 | 2025-06-24 |
| A Study to Evaluate the Safety and Pharmacokinetics of Dapagliflozin, Linagliptin, and Metformin in Healthy Adults: Fed State Study Comparator 1, Comparator 2, Test Drug - Type2 Diabetes Mellitus | Phase 1 | Not yet recruiting | AJU Pharm Co., Ltd. | 32 | 2025-08-01 | 2025-07-01 |
| Effects of Marching Exercise With Cognitive Training on Physical, Cognitive Function, and Autonomic Cardiovascular Responses in Older Adults With Type 2 Diabetes Mellitus Modified Marching Exercise combined with cognitive training group, Modified Marching Exercise group - Type2 Diabetes Mellitus, Autonomic Nervous System Imbalance | Not applicable | Completed | Chonticha Kaewjoho | 60 | 2025-07-10 | 2026-01-14 |
| Observational Study on GER in Patients With Simple Obesity Gastric emptying scintigraphy - Obesity &Amp;Amp; Overweight, Gastric Emptying Time | Completed | Jing Ma | 163 | 2025-07-01 | 2026-03-04 | |
| A Study to Assess Effect of Glucocil® on Metabolic Health in Individuals With Prediabetes and Type 2 Diabetes Mellitus. IP 1200 mg per soft gel capsule, Placebo Comparator: Placebo 1200 mg per soft gel capsule - Pre Diabetes, Type2 Diabetes Mellitus | Not applicable | Completed | Vedic Lifesciences Pvt. Ltd. | 104 | 2024-09-12 | 2026-10-05 |
| Effort During Resistance Training in Type 2 Diabetes High-effort resistance exercise training, Low-effort resistance exercise training - Type2 Diabetes Mellitus | Not applicable | Completed | University of New Mexico | 14 | 2024-09-10 | 2026-09-03 |
| A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin Exendin-4 Fc fusion protein injection(1.2mg）, Exendin-4 Fc fusion protein injection（2.4mg）, Dulaglutide - Type2 Diabetes Mellitus | Phase 3 | Active not recruiting | Beijing Dongfang Biotech Co., Ltd. | 600 | 2024-07-17 | 2025-09-17 |
| Effects of a Health Intervention on Fear of Hypoglycemia Routine Care, Based on BCW Theory of Health Education - Health-Related Behavior, Health Education | Not applicable | Unknown | Yangzhou University | 90 | 2024-07-01 | 2024-07-09 |
| Effect of Henagliflozein on Hepatic Fat Content in Patients With T2DM and NAFLD Henagliflozein and Metformin, Linagliptin and Metformin - Type2 Diabetes Mellitus, Nonalcoholic Fatty Liver Disease | Phase 4 | Recruiting | Zhujiang Hospital | 100 | 2024-06-01 | 2024-06-10 |
| A Study to Compare the Pharmacokinetics and the Safety Between a Fixed-dose Combination Administration of "BR3005" and Co-administration of "BR3005-1" and "BR3005-2" Under Fed Conditions in Healthy Adult Volunteers BR3005, BR3005-1, BR3005-2 - Type2 Diabetes Mellitus | Phase 1 | Completed | Boryung Pharmaceutical Co., Ltd | 40 | 2024-03-05 | 2024-05-24 |
| Bioequivalence Study of Empagliflozin 25 mg Film Coated Tablets of Humanis, Turkey and Jardiance (Empagliflozin) 25 mg Film-coated Tablets of Boehringer Ingelheim International GmbH, Germany in Normal, Healthy, Adult, Human Subjects Under Fasting Condition Empagliflozin film coated tablets, Jardiance film-coated tablets - Type2 Diabetes Mellitus | Phase 1 | Completed | Humanis Saglık Anonim Sirketi | 36 | 2023-07-30 | 2023-12-22 |
| Nephroprotective Effect of Nicorandil in Type 2 Diabetes Mellitus Nicorandil 10 MG Oral Tablet - Type2 Diabetes Mellitus | Phase 3 | Unknown | Tanta University | 46 | 2023-02-28 | 2024-05-28 |
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Diabetes Mellitus, Type 2 (19) · Obesity (12) · Diabetes Mellitus (11) · Cardiovascular Diseases (7) · Insulin Resistance (7) · Non-alcoholic Fatty Liver Disease (6) · Overweight (5) · Health Behavior (4) · Motor Activity (4) · Glucose Intolerance (3) · Metabolic Syndrome (3) · Albuminuria (2) · Atherosclerosis (2) · Glucose Metabolism Disorders (2) · Prediabetic State (2)
Nutritional and Metabolic Diseases (44) · Metabolic Diseases (39) · Glucose Metabolism Disorders (38) · Endocrine System Diseases (31) · Diabetes Mellitus (21) · Pathological Conditions, Signs and Symptoms (21) · Signs and Symptoms (17) · Body Weight (12) · Nutrition Disorders (12) · Overnutrition (12) · Hyperinsulinism (9) · Behavior (8) · Digestive System Diseases (7) · Overweight (7) · Vascular Diseases (7)
Metformin (5) · bexagliflozin (5) · dapagliflozin (4) · empagliflozin (4) · Linagliptin (3) · Sitagliptin Phosphate (3) · glimepiride (3) · Drug Evaluation (2) · Exercise (2) · Tablets (2) · dulaglutide (2) · lobeglitazone (2) · saxagliptin (2) · 3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine (1) · 4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one (1)
Chong Kun Dang Pharmaceutical (6) · Theracos (5) · PegBio Co., Ltd. (3) · AJU Pharm Co., Ltd. (2) · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics (2) · Leiden University Medical Center (2) · Mathias Ried-Larsen (2) · Nanjing First Hospital, Nanjing Medical University (2) · Peking Union Medical College Hospital (2) · Sansum Diabetes Research Institute (2) · Zhujiang Hospital (2) · Aga Khan University (1) · Andalas University (1) · Assiut University (1) · Associacao para Investigacao e Desenvolvimento da Faculdade de Medicina - CETERA (1)
United States (27) · China (13) · South Korea (11) · India (6) · Denmark (3) · Egypt (3) · Japan (3) · United Kingdom (3) · Brazil (2) · Germany (2) · Indonesia (2) · Israel (2) · Italy (2) · Netherlands (2) · Spain (2)
Mason Freeman, M.D. (3) · Ahmed Biad, professor (1) · Alvina Alvina (1) · Amnon Lahad, MD, MPH (1) · Andrea Giaccari (1) · Ayeesha Kamal, MD (1) · Barbara Rogers, MD (1) · Beatriz D Schaan, PhD (1) · Caroline M Kistorp, MD, PhD. (1) · David Kerr, M.D. (1) · David Kerr, MBChB DM FRCP (1)
PMID 10535433, PMID 10705560, PMID 10857933, PMID 10912903, PMID 10993420, PMID 11689544, PMID 11985936, PMID 15249533, PMID 1563586, PMID 16103523, PMID 16925881, PMID 17249253, PMID 19114612, PMID 19255424, PMID 21112026, PMID 22025886, PMID 22424658, PMID 22431131, PMID 22446170, PMID 22496545, PMID 22554256, PMID 22804249, PMID 23383649, PMID 23384119, PMID 23439165, PMID 23466761, PMID 23563279, PMID 23707905, PMID 24433933, PMID 24458353, PMID 24459063, PMID 24463448, PMID 24463454, PMID 24493081, PMID 24619655, PMID 24712570, PMID 24742660, PMID 24829483, PMID 24889731, PMID 25018121, PMID 25404342, PMID 25482832, PMID 25599827, PMID 25745497, PMID 25870289, PMID 25904601, PMID 25927923, PMID 26089386, PMID 26411343, PMID 26414564
2016 (2), P01AG011412 (1), P30DK111024 (1), R01HL137716 (1), U48DP006778 (1)