7 completed. 7 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 7 |
| Phase 1 | 3 | Completed 3 |
Follow Systemic Scleroderma: new trials by email Literature Review of Systemic Scleroderma trials Research Report on Systemic Scleroderma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of Topical C-82 in Systemic Sclerosis - A Phase I/II Biomarker and Safety Trial C-82 Topical Gel, 1%, C-82 Topical Gel, Placebo - Systemic Scleroderma | Phase 1 / Phase 2 | Completed | Prism Pharma Co., Ltd. | 17 | 2015-06-01 | 2017-08-17 |
| Treatment of Refractory Sever Systemic Scleroderma by Injection of Allogeneic Mesenchymal Stem Cells INJECTION OF ALLOGENEIC MESENCHYMAL STEM CELLS - SYSTEMIC SCLERODERMA, ALLOGENEIC MESENCHYMAL STEM CELLS | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 20 | 2014-05-06 | 2024-05-01 |
| Scleroderma Treatment With Autologous Transplant (STAT) Study Anti-Thymocyte Globulin, Autologous Hematopoietic Stem Cell Transplantation, Cyclophosphamide - Systemic Scleroderma | Phase 2 | Completed | Fred Hutchinson Cancer Center | 21 | 2011-09-15 | 2025-01-07 |
| Imatinib and Rituximab in Treating Cutaneous Sclerosis in Patients With Chronic Graft-Versus-Host Disease imatinib mesylate, rituximab - Graft Versus Host Disease, Systemic Scleroderma | Phase 2 | Completed | Lee, Stephanie | 72 | 2011-03-01 | 2016-06-15 |
| Allogeneic Hematopoietic Cell Transplantation for Severe Systemic Sclerosis fludarabine phosphate, Mycophenolic Acid, tacrolimus - Systemic Scleroderma, Severe Systemic Sclerosis | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 3 | 2006-09-01 | 2018-06-04 |
| Effect of Bosentan on Skin Fibrosis in Patients With Systemic Sclerosis Bosentan (Tracleer) - Systemic Scleroderma, Skin Fibrosis | Phase 2 | Completed | Heinrich-Heine University, Duesseldorf | 10 | 2006-06-01 | 2007-09-10 |
| Cyclophosphamide and rATG With Hematopoietic Stem Cell Support in Systemic Scleroderma standard of care, stem cell transplantation - SYSTEMIC SCLERODERMA | Phase 2 | Completed | Northwestern University | 19 | 2005-09-01 | 2014-04-30 |
Scleroderma, Systemic (7) · Scleroderma, Diffuse (2) · Graft vs Host Disease (1)
Connective Tissue Diseases (7) · Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Immune System Diseases (1)
Mycophenolic Acid (2) · Stem Cell Transplantation (2) · Antilymphocyte Serum (1) · Biopsy (1) · Bone Marrow Transplantation (1) · Bosentan (1) · Cyclophosphamide (1) · Filgrastim (1) · Flow Cytometry (1) · Granulocyte Colony-Stimulating Factor (1) · Imatinib Mesylate (1) · Peripheral Blood Stem Cell Transplantation (1) · Rituximab (1) · Standard of Care (1) · Tacrolimus (1)
Fred Hutchinson Cancer Center (2) · Assistance Publique - Hôpitaux de Paris (1) · Heinrich-Heine University, Duesseldorf (1) · Lee, Stephanie (1) · Northwestern University (1) · Prism Pharma Co., Ltd. (1)
United States (5) · France (1) · Germany (1)
Annegret Kuhn, MD (1) · George Georges (1) · Leona Holmberg (1) · Richard Burt, MD (1) · Robert Lafyatis, MD (1) · Stephanie Lee (1)
PMID 21777972, PMID 26378033, PMID 35904231, PMID 36928395, PMID 39348419, PMID 39624016
P30CA015704 (2), 2005 (1), R01AI041721 (1), U54CA163438 (1)