2 not yet recruiting, 2 recruiting, 1 active not recruiting, 1 completed. 3 Phase 2, 2 Phase 1, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Active not recruiting 1, Completed 1, Recruiting 1 |
| Phase 1 | 2 | Enrolling by invitation 1, Not yet recruiting 1 |
| Phase 3 | 2 | Not yet recruiting 1, Recruiting 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
Follow Stiff Person Syndrome: new trials by email Literature Review of Stiff Person Syndrome trials Research Report on Stiff Person Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Investigating Intravenous Human Normal Immune Globulin 10% in Adults With Stiff Person Syndrome Kedrion IVIg 10%, Human Albumin - Stiff Person Syndrome | Phase 3 | Not yet recruiting | Kedrion S.p.A. | 38 | 2026-11-01 | 2026-10-22 |
| VYVGART (Hytrulo) in Patients With Stiff Person Syndrome (SPS) VYVGART Hytrulo, Hytrulo-placebo (consisting of Hyaluronidase) - Stiff Person Syndrome | Phase 2 / Phase 3 | Recruiting | Thomas Jefferson University | 26 | 2026-09-30 | 2026-10-06 |
| Extracorporeal Photopheresis (ECP) in the Treatment of Stiff Person Syndrome (OPTION Study) Extracorporeal photopheresis (ECP) - Stiff Person Syndrome | Early Phase 1 | Withdrawn | Yandy Marx Castillo Aleman | 2026-08-01 | 2026-08-06 | |
| A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy CD20/BCMA-directed CAR-T cells - Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) | Phase 1 | Not yet recruiting | Huashan Hospital | 15 | 2026-02-01 | 2026-01-15 |
| A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101 KYV-101 - Refractory Lupus Nephritis, Myasthaenia Gravis | Recruiting | Kyverna Therapeutics | 70 | 2025-11-24 | 2026-02-11 | |
| A Phase 1 Study of Prulacabtagene Leucel (Prula-cel, Formerly ADI-001) in Autoimmune Disease ADI-001, Fludarabine, Cyclophosphamide - Lupus Nephritis, Autoimmune Diseases | Phase 1 | Enrolling by invitation | Adicet Therapeutics | 180 | 2024-11-10 | 2026-03-19 |
| Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases Anti-Thymocyte Globulin, Autologous Hematopoietic Stem Cell Transplantation, Carmustine - Autoimmune Disease, Neurologic Autoimmune Disease | Phase 2 | Active not recruiting | Fred Hutchinson Cancer Center | 53 | 2008-06-01 | 2026-02-27 |
| Rituximab to Treat Stiff Person Syndrome Rituximab, rituximab or placebo - Stiff Person Syndrome | Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 24 | 2004-09-01 | 2011-08-31 |
Stiff-Person Syndrome (8) · Autoimmune Diseases (3) · Autoimmune Diseases of the Nervous System (2) · Lupus Nephritis (2) · Multiple Sclerosis (2) · Neuromyelitis Optica (2) · Scleroderma, Systemic (2) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (1) · Arthritis, Rheumatoid (1) · Dermatomyositis (1) · Lambert-Eaton Myasthenic Syndrome (1) · Lupus Erythematosus, Systemic (1) · Myasthenia Gravis (1) · Myositis (1) · Nervous System Diseases (1)
Central Nervous System Diseases (8) · Immune System Diseases (8) · Neuromuscular Diseases (8) · Spinal Cord Diseases (8) · Nervous System Diseases (7) · Autoimmune Diseases of the Nervous System (6) · Autoimmune Diseases (5) · Demyelinating Autoimmune Diseases, CNS (3) · Demyelinating Diseases (3) · Cardiovascular Diseases (2) · Connective Tissue Diseases (2) · Cranial Nerve Diseases (2) · Eye Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2)
Antilymphocyte Serum (1) · Carmustine (1) · Cyclophosphamide (1) · Cytarabine (1) · Etoposide (1) · Melphalan (1) · Peripheral Blood Stem Cell Transplantation (1) · Photopheresis (1) · Prednisone (1) · Rituximab (1) · Serum Albumin, Human (1) · carmustine, poliferprosan 20 drug combination (1) · deltacortene (1) · fludarabine (1) · prednylidene (1)
Adicet Therapeutics (1) · Fred Hutchinson Cancer Center (1) · Huashan Hospital (1) · Kedrion S.p.A. (1) · Kyverna Therapeutics (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Thomas Jefferson University (1) · Yandy Marx Castillo Aleman (1)
United States (5) · United Arab Emirates (1)
Leona Holmberg (1) · Miranda Norton, PhD (1)