18 recruiting, 15 active not recruiting, 13 completed, 4 withdrawn. 18 Not applicable, 16 Phase 2, 8 Phase 3, 7 Phase 1, 3 Early Phase 1.
Follow Stage III Prostate Cancer AJCC v8: new trials by email Literature Review of Stage III Prostate Cancer AJCC v8 trials Research Report on Stage III Prostate Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer Aerobic Exercise, Biopsy Procedure, Biospecimen Collection - Colon Polyp, Colorectal Carcinoma | Not applicable | Recruiting | City of Hope Medical Center | 30 | 2026-12-16 | 2026-08-28 |
| CT- Versus MRI-Based Planning for High-Dose-Rate Prostate Brachytherapy for Prostate Cancer Magnetic Resonance Imaging, Questionnaire Administration - Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Not yet recruiting | Emory University | 100 | 2026-11-02 | 2026-10-09 |
| Image-Guidance and Online Adaptation With Stereotactic Body Radiation Therapy for the Treatment of Localized Prostate Cancer, MANTICORE Trial Biospecimen Collection, Computed Tomography, CT-guided Stereotactic Body Radiation Therapy - Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Jonsson Comprehensive Cancer Center | 186 | 2025-12-01 | 2026-02-05 |
| Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer Cancer Therapeutic Procedure, Health Care Delivery, Questionnaire Administration - Biochemically Recurrent Prostate Carcinoma, Locally Advanced Prostate Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 38 | 2025-08-27 | 2026-03-25 |
| Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial Biospecimen Collection, Computed Tomography, Flotufolastat F-18 Gallium - Prostate Adenocarcinoma, Stage IIC Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 30 | 2025-08-25 | 2026-09-23 |
| Feasibility and Effect of Wrapping Nerves With a Multi-Layer Perinatal Tissue Allograft During Prostatectomy Allografting, Survey Administration - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 45 | 2025-08-14 | 2026-09-11 |
| Computed Tomography-Guided Stereotactic Body Radiation Therapy With Intrafraction Motion Monitoring for the Treatment of Localized Prostate Cancer, ILLUSION Trial Biospecimen Collection, Computed Tomography, CT-guided Stereotactic Body Radiation Therapy - Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Active not recruiting | Jonsson Comprehensive Cancer Center | 91 | 2025-06-27 | 2026-08-20 |
| A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer Abemaciclib, Biopsy, Bone Scan - Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm | Phase 2 | Terminated | OHSU Knight Cancer Institute | 6 | 2025-06-24 | 2026-04-28 |
| Pembrolizumab With Androgen Deprivation Therapy and Radiotherapy for the Treatment of Patients With High Risk Localized Prostate Cancer Gonadotropin Releasing Hormone Agonists and Antagonists, Bicalutamide, Biopsy Procedure - High Risk Prostate Carcinoma, Localized Prostate Adenocarcinoma | Phase 2 | Withdrawn | OHSU Knight Cancer Institute | 2025-04-16 | 2025-09-23 | |
| Autologous T Cells Lentivirally Transduced to Express L1CAM-Specific Chimeric Antigen Receptors in Treating Patients With Locally Advanced and Unresectable or Metastatic Small Cell Neuroendocrine Prostate Cancer Bendamustine, Biopsy, Biospecimen Collection - Prostate Carcinoma, Prostate Small Cell Neuroendocrine Carcinoma | Phase 1 | Withdrawn | Fred Hutchinson Cancer Center | 2025-04-15 | 2025-04-01 | |
| REVELUTION-2: Relugolix+Abiraterone Acetate (AA) Versus Leuprolide+AA Cardiac Trial Abiraterone Acetate, Bicalutamide, Biospecimen Collection - Recurrent Prostate Carcinoma, Stage III Prostate Cancer AJCC v8 | Phase 3 | Recruiting | Emory University | 72 | 2025-01-31 | 2026-02-24 |
| Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance Biopsy of Prostate, Biospecimen Collection, Magnetic Resonance Imaging - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Phase 4 | Recruiting | Roswell Park Cancer Institute | 600 | 2025-01-15 | 2026-05-14 |
| Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation Patient Navigation, Genetic Counseling, Survey Administration - Metastatic Prostate Carcinoma, Stage III Prostate Cancer AJCC v8 | Not applicable | Recruiting | Thomas Jefferson University | 120 | 2025-01-01 | 2026-10-22 |
| Adaptive Radiation Therapy (ART) Stereotactic Ablative Body Radiotherapy (SABR) for Primary Localized Prostate Cancer Computed Tomography, Cone-Beam Computed Tomography, Image-Guided Adaptive Radiation Therapy - Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 164 | 2024-08-15 | 2026-10-14 |
| Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy Bright White Light Therapy, Combination Drug Therapy, Electronic Health Record Review - Advanced Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 210 | 2024-07-09 | 2026-10-07 |
| Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer Bilateral Pelvic Lymph Node Dissection, Biospecimen Collection, Bone Scan - Localized Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Not applicable | Recruiting | Mayo Clinic | 50 | 2024-06-11 | 2026-04-06 |
| SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma Antiandrogen Therapy, Biospecimen Collection, Hypofractionated Radiation Therapy - Biochemically Recurrent Prostate Carcinoma, Oligometastatic Prostate Carcinoma | Phase 3 | Active not recruiting | Mayo Clinic | 118 | 2024-04-04 | 2026-09-17 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer Biospecimen Collection, Bone Scan, Computed Tomography - Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 1209 | 2023-12-14 | 2026-09-10 |
| Vitamin D for Prostate Endocrine Therapy Biospecimen Collection, D Vitamin, Dual X-ray Absorptiometry - Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8 | Phase 3 | Recruiting | University of Rochester | 240 | 2023-12-14 | 2026-01-15 |
| Relugolix in Combination With Radiation Therapy for Treating Patients With High Risk Prostate Cancer Biospecimen Collection, Bone Scan, Brachytherapy - Stage IIC Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8 | Phase 2 | Not yet recruiting | University of Kansas Medical Center | 90 | 2023-11-20 | 2023-11-13 |
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Prostatic Neoplasms (56) · Ovarian Neoplasms (7) · Colorectal Neoplasms (6) · Pancreatic Neoplasms (4) · Breast Neoplasms (3) · Neoplasm Metastasis (3) · Carcinoma, Renal Cell (2) · Carcinoma, Transitional Cell (2) · Lung Neoplasms (2) · Triple Negative Breast Neoplasms (2) · Urinary Bladder Neoplasms (2) · Urogenital Neoplasms (2) · Brain Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Medullary (1)
Genital Diseases (56) · Genital Diseases, Male (56) · Genital Neoplasms, Male (56) · Male Urogenital Diseases (56) · Neoplasms by Site (56) · Prostatic Diseases (56) · Urogenital Diseases (56) · Neoplasms (55) · Urogenital Neoplasms (54) · Digestive System Diseases (11) · Digestive System Neoplasms (11) · Female Urogenital Diseases (8) · Female Urogenital Diseases and Pregnancy Complications (8) · Gastrointestinal Diseases (8) · Adnexal Diseases (7)
Specimen Handling (22) · Magnetic Resonance Spectroscopy (19) · Radiation (11) · Radiotherapy (8) · Biopsy (6) · relugolix (6) · Radiosurgery (5) · Brachytherapy (4) · Leuprolide (4) · Exercise Test (3) · Prednisone (3) · Radiation Dose Hypofractionation (3) · apalutamide (3) · bicalutamide (3) · deltacortene (3)
Mayo Clinic (9) · M.D. Anderson Cancer Center (8) · Jonsson Comprehensive Cancer Center (5) · City of Hope Medical Center (4) · Emory University (4) · NRG Oncology (4) · National Cancer Institute (NCI) (4) · University of Southern California (4) · OHSU Knight Cancer Institute (3) · Roswell Park Cancer Institute (2) · Thomas Jefferson University (2) · Fred Hutchinson Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · Ryan Kohlbrenner, MD (1) · University of California, Davis (1)
United States (55) · Canada (4) · Hong Kong (1) · Puerto Rico (1) · Switzerland (1)
Dalnim Cho (2) · Ram A. Pathak, MD (2) · Sagar A Patel, MD (2) · A P Chen (1) · Ahmed Aly (1) · Alison M Schram (1) · Amar Kishan (1) · Amar W. Kishan, MD (1) · Amy Leader, DrPH, MPH (1) · Arnold Chin (1) · Arthur Hung (1) · Carlos E. Vargas, M.D. (1) · Carlos E. Vargas, MD (1) · Charles D Lopez, MD, PhD (1) · Delphine L. Chen, M.D. (1)
PMID 33962579, PMID 34461975, PMID 34741653, PMID 36351402, PMID 36435952, PMID 38421243, PMID 38664019, PMID 39136560, PMID 39254446, PMID 39536751, PMID 40939237, PMID 41706486, PMID 42077327, PMID 42847673
P30CA014089 (4), P30CA033572 (4), P30CA138292 (4), U10CA180868 (4), P30CA016672 (2), P30CA015083 (1), P30CA016042 (1), P30CA093373 (1), P30CA168524 (1), R01CA218093 (1), R01CA258349 (1), R21AG078258 (1), R37CA292795 (1), UG1CA189961 (1), UM1CA186691 (1)