9 recruiting, 7 completed, 4 active not recruiting, 3 terminated. 10 Phase 2, 6 Not applicable, 6 Phase 1, 2 Early Phase 1, 1 Phase 3.
Follow Soft Tissue Sarcoma Adult: new trials by email Literature Review of Soft Tissue Sarcoma Adult trials Research Report on Soft Tissue Sarcoma Adult
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall Moderately hypofractionated neoadjuvant radiotherapy - Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma (Excluding GIST) | Phase 2 | Recruiting | Centre Oscar Lambret | 135 | 2026-07-21 | 2026-07-23 |
| Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. Definitive radiotherapy - Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 40 | 2026-01-26 | 2026-01-28 |
| Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma preoperative, Quality of life, Functional outcome - Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 110 | 2026-01-26 | 2026-01-28 |
| A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors PBA-0111 - Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult | Early Phase 1 | Recruiting | Pure Biologics S.A. | 12 | 2025-03-27 | 2025-08-11 |
| Fluorescent Aided Resection and Evaluation of Soft Tissue Sarcomas (FLARES) Aminolevulinic Acid - Soft Tissue Sarcoma, Soft Tissue Sarcoma Adult | Phase 1 | Withdrawn | University of California, Davis | 2024-07-01 | 2024-08-15 | |
| A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors PBA-0405 - Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult | Early Phase 1 | Completed | Pure Biologics S.A. | 8 | 2024-04-29 | 2025-08-11 |
| A Study of Surufatinib in the Treatment of Advanced Soft Tissue Sarcoma Surufatinib - Soft Tissue Sarcoma Adult | Not applicable | Unknown | Fudan University | 29 | 2023-11-28 | 2023-10-31 |
| Sarcomas and DDR-Inhibition; a Combined Modality Study AZD1390 + radiotherapy, AZD1390 + durvlaumab + radiotherapy - Soft Tissue Sarcoma Adult | Phase 1 | Terminated | The Netherlands Cancer Institute | 12 | 2022-07-18 | 2026-01-23 |
| Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas Association of pembrolizumab + cabozantinib - Soft Tissue Sarcoma Adult, Advanced Soft-tissue Sarcoma | Phase 2 | Recruiting | Institut Bergonié | 119 | 2022-04-25 | 2025-10-07 |
| Phase 1 Study of SON-1010 in Adult Patients With Advanced Solid Tumors SON-1010 - Advanced Solid Tumor, Soft Tissue Sarcoma Adult | Phase 1 | Active not recruiting | Sonnet BioTherapeutics | 42 | 2022-04-20 | 2026-02-03 |
| Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients Observational Translational Study - Sarcoma, Sarcoma, Leiomyo-, Adult | Recruiting | Royal Marsden NHS Foundation Trust | 800 | 2021-11-19 | 2026-02-25 | |
| Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma Patients Propranolol, Pembrolizumab - Soft Tissue Sarcoma Adult, Angiosarcoma | Phase 2 | Recruiting | Niels Junker | 80 | 2021-08-17 | 2023-07-27 |
| Blood and Tissue Extraction for Immunological Examinations During Neoadjuvant Therapy of Soft Tissue Sarcomas Blood and tissue collection for immunological studies, advanced imaging., neoadjuvant Therapy - Soft Tissue Sarcoma Adult | Not applicable | Active not recruiting | University Hospital Tuebingen | 30 | 2021-07-21 | 2026-10-13 |
| Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma Retifanlimab, Gemcitabine, Docetaxel - Soft Tissue Sarcoma, Sarcoma,Soft Tissue | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 98 | 2020-09-29 | 2026-09-08 |
| Pre-operative RadiothErapy for Soft Tissue SarcOmas Hypofractionation - Soft Tissue Sarcoma Adult | Not applicable | Active not recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 15 | 2020-06-05 | 2025-06-25 |
| Combination of Nivolumab Plus Relatlimab in Patients With Advanced or Metastatic Soft-tissue Sarcoma: a Proof-of-concept Randomized Phase II Study Association of Nivolumab + Relatlimab, Nivolumab - Soft Tissue Sarcoma Adult, Advanced Cancer | Phase 2 | Completed | Institut Bergonié | 68 | 2020-02-27 | 2026-04-21 |
| Combined Treatment of Patients With Soft Tissue Sarcoma Including Preoperative Stereotactic Radiation Therapy and Postoperative Conformal Radiation Therapy Preoperative stereotactic radiation therapy in hypofractionation mode, Surgery, Postoperative conformal radiation therapy in normofractionation mode - Soft Tissue Sarcoma Adult | Not applicable | Recruiting | N.N. Petrov National Medical Research Center of Oncology | 30 | 2020-02-01 | 2020-04-01 |
| Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients Trabectedin - Soft Tissue Sarcoma Adult, Undifferentiated Pleomorphic Sarcoma | Not applicable | Completed | Institut Bergonié | 29 | 2020-01-06 | 2026-03-06 |
| Efficacy and Safety of Anlotinib in Adjuvant Therapy for High-grade Soft Tissue Sarcoma Anlotinib Hydrochloride, Placebo Oral Tablet - Soft Tissue Sarcoma Adult, High Grade Sarcoma | Phase 2 | Completed | Fudan University | 88 | 2019-05-13 | 2025-05-14 |
| Study of a Cohort of Cases of Synovial Sarcoma Treated in the Orthopedic Surgery and Traumatology Department of the Hospital de Sant Pau Between 1983 and 2016 Soft tissue sarcomas in adults - Soft Tissue Sarcoma Adult | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 102 | 2019-02-01 | 2020-02-24 |
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Sarcoma (16) · Histiocytoma, Malignant Fibrous (5) · Leiomyosarcoma (4) · Liposarcoma (4) · Sarcoma, Synovial (4) · Dermatofibrosarcoma (2) · Hemangiosarcoma (2) · Squamous Cell Carcinoma of Head and Neck (2) · Triple Negative Breast Neoplasms (2) · Hemangioendothelioma (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Osteosarcoma (1) · Sarcoma, Ewing (1) · Solitary Fibrous Tumors (1)
Neoplasms by Histologic Type (19) · Neoplasms (18) · Neoplasms, Connective and Soft Tissue (17) · Neoplasms, Connective Tissue (6) · Histiocytoma (5) · Neoplasms, Fibrous Tissue (5) · Neoplasms, Adipose Tissue (4) · Neoplasms, Muscle Tissue (4) · Neoplasms, Vascular Tissue (3) · Breast Diseases (2) · Breast Neoplasms (2) · Carcinoma (2) · Carcinoma, Squamous Cell (2) · Fibrosarcoma (2) · Head and Neck Neoplasms (2)
Docetaxel (2) · Doxorubicin (2) · Gemcitabine (2) · Nivolumab (2) · Trabectedin (2) · eribulin (2) · pembrolizumab (2) · AZD1390 (1) · Absorptiometry, Photon (1) · Aminolevulinic Acid (1) · Blood Specimen Collection (1) · Bortezomib (1) · Control Groups (1) · Cyclophosphamide (1) · Geriatric Assessment (1)
Institut Bergonié (4) · Fudan University (2) · Oslo University Hospital (2) · Pure Biologics S.A. (2) · Centre Oscar Lambret (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · GWT-TUD GmbH (1) · Istituto Oncologico Veneto IRCCS (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Memorial Sloan Kettering Cancer Center (1) · N.N. Petrov National Medical Research Center of Oncology (1) · National Taiwan University Hospital (1) · Niels Junker (1) · Peking University People's Hospital (1) · Presage Biosciences (1)
United States (7) · France (5) · Norway (3) · China (2) · Germany (2) · Canada (1) · Denmark (1) · Italy (1) · Netherlands (1) · Russia (1) · Spain (1) · Sweden (1) · Taiwan (1) · United Kingdom (1)
Ivar Hompland, MD, PhD (2) · Kjetil Boye, MD, PhD (2) · Antonella Brunello (1) · Claudia Lamas (1) · Fabio Cury, MD (1) · Gary Deutsch, MD (1) · John Weinberg (1) · John Weinberg, MBBCH (1) · Kenneth Gundle, MD (1) · Markus Schuler, Dr. (1) · Niels Junker, MD, PhD (1) · Richard Kenney, MD (1) · Rick Haas, MD Prof (1) · Robin Jones, MD (1)
PMID 32299817, PMID 36129471, PMID 39918552
2019 (1)