3 completed, 1 unknown, 1 withdrawn. 5 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 5 | Completed 3, Unknown 1, Withdrawn 1 |
Follow Scleroderma, Diffuse: new trials by email Literature Review of Scleroderma, Diffuse trials Research Report on Scleroderma, Diffuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyaluronidase Via LADD Scleroderma-induced Microstomia Hyaluronidase, CO2 laser - Microstomia, Scleroderma | Early Phase 1 | Completed | University of Nebraska | 3 | 2024-03-01 | 2026-04-15 |
| A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Scleroderma Assigned Interventions CD19/BCMA CAR T-cells - Scleroderma, Autoimmune Diseases | Early Phase 1 | Unknown | Zhejiang University | 9 | 2021-10-08 | 2021-10-20 |
| The Effects of Botulinum Toxin on Oral Aperture in Patients With Scleroderma Botulinum toxin(Botox) - Scleroderma | Early Phase 1 | Completed | University of Texas Southwestern Medical Center | 17 | 2020-05-08 | 2021-04-28 |
| Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease hyaluronidase injected intradermally - Microstomia, Scleroderma | Early Phase 1 | Withdrawn | Brigham and Women's Hospital | 2020-01-01 | 2021-01-14 | |
| Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud 10% nifedipine cream, 5% sildenafil cream - Raynaud Phenomenon Due to Trauma, Raynaud Disease | Early Phase 1 | Completed | Pontificia Universidad Catolica de Chile | 10 | 2016-08-01 | 2017-01-23 |
Microstomia (2) · Autoimmune Diseases (1) · CREST Syndrome (1) · Dermatomyositis (1) · Lupus Erythematosus, Systemic (1) · Raynaud Disease (1) · Scleroderma, Localized (1) · Scleromyxedema (1)
Connective Tissue Diseases (5) · Scleroderma, Systemic (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Cardiovascular Diseases (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Embolism and Thrombosis (2) · Immune System Diseases (2) · Livedoid Vasculopathy (2) · Mouth Abnormalities (2) · Mouth Diseases (2) · Peripheral Vascular Diseases (2) · Skin Diseases, Vascular (2) · Stomatognathic Diseases (2)
Botulinum Toxins, Type A (1) · Chondroitinases and Chondroitin Lyases (1) · Hyaluronoglucosaminidase (1) · Lasers, Gas (1) · Therapeutics (1)
Brigham and Women's Hospital (1) · Pontificia Universidad Catolica de Chile (1) · University of Nebraska (1) · University of Texas Southwestern Medical Center (1) · Zhejiang University (1)
United States (2) · Chile (1) · China (1)
Cristian Vera-Kellet, MD (1) · He Huang, PhD (1) · Heather Goff, MD (1) · Sarah L Lonowski, MD (1)