17 recruiting, 13 completed, 7 active not recruiting, 5 unknown. 23 Phase 2, 12 Phase 1, 6 Not applicable, 2 Phase 3, 1 Early Phase 1.
Follow Sarcoma,Soft Tissue: new trials by email Literature Review of Sarcoma,Soft Tissue trials Research Report on Sarcoma,Soft Tissue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility Study Tirzepatide - Sarcoma,Soft Tissue | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 30 | 2026-10-14 | 2026-10-20 |
| Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO) 2% intranasal mupirocin ointment, 4% chlorhexidine gluconate body cleanser - Sarcoma,Soft Tissue | Phase 2 | Not yet recruiting | Adam Olson | 31 | 2026-09-30 | 2026-02-09 |
| BOLD-100 Plus Doxorubicin in Advanced Soft Tissue Sarcomas BOLD-100, Doxorubicin 75 mg/m^2 - Sarcoma, Soft-tissue, Sarcoma | Phase 1 | Not yet recruiting | University Health Network, Toronto | 32 | 2026-03-30 | 2025-12-01 |
| Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) Cohort A: Extensive Stage Small Cell Lung Cancer (ES-SCLC) Thoracic Tumor PULSAR (Personalized ultrahypofractionated stereotactic ablative radiotherapy), Cohort B: Brain metastasis PULSAR (Personalized ultrahypofractionated stereotactic ablative radiotherapy), Cohort C: Sarcoma Pre-Operative PULSAR - Small Cell Lung Cancer Extensive Stage, Brain Metastases | Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 105 | 2025-10-28 | 2026-08-17 |
| Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma (TNT-HYPE) Doxorubicin, Ifosfamide, Dacarbazine - Sarcoma,Soft Tissue | Phase 2 | Recruiting | Swiss Cancer Institute | 24 | 2025-10-27 | 2025-12-30 |
| Preventive Application of Single-use Negative Pressure Wound Therapy (sNPWT) in the Postoperative Course of Radiotreatated Limb Sarcoma Surgery PICO 14 - Sarcoma, Sarcoma,Soft Tissue | Not applicable | Recruiting | Istituto Oncologico Veneto IRCCS | 48 | 2025-09-15 | 2025-12-02 |
| Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced Sarcomas CD146/HER2 CAR-T cells - Sarcoma, Sarcoma, Kaposi | Phase 1 / Phase 2 | Recruiting | Essen Biotech | 60 | 2025-05-29 | 2025-07-15 |
| Descriptive Cohort of French Patients Treated With Carbonetherapy Since October 2010 Outside PHRC-ETOILE Questionnaire - Cancer, Cystic Carcinomas, Adenoid | Completed | Hospices Civils de Lyon | 62 | 2025-05-23 | 2025-08-06 | |
| Neoadjuvant Intralesional Injection of Talimogene Laherparepvec Talimogene Laherparepvec, Neoadjuvant Radiation, Surgery - Soft Tissue Sarcoma, Sarcoma,Soft Tissue | Phase 2 | Active not recruiting | John Rieth | 2 | 2025-03-03 | 2026-07-17 |
| High Versus Lower Intensity Surveillance Following Resection of Retroperitoneal Sarcoma High-intensity radiological surveillance, Lower-intensity radiological surveillance - Sarcoma,Soft Tissue, Sarcoma Retroperitoneal | Phase 3 | Not yet recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 584 | 2024-11-01 | 2024-10-16 |
| Phase II Clinical Trial of Chidamide Combined With AK112 for Second-line and Advanced Bone and Soft Tissue Sarcoma Chidamide Tablets combined with AK112 - Sarcoma,Soft Tissue, Sarcoma | Phase 2 | Recruiting | Shanxi Province Cancer Hospital | 30 | 2024-08-01 | 2024-10-15 |
| A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3) INT230-6, Eribulin, Trabectedin - Sarcoma,Soft Tissue | Phase 3 | Recruiting | Intensity Therapeutics, Inc. | 333 | 2024-06-28 | 2026-08-11 |
| Neoadjuvant ADI-PEG 20 + Ifosfamide + Radiotherapy in Soft Tissue Sarcoma ADI PEG20, Ifosfamide, Radiotherapy - Soft Tissue Sarcoma, Sts | Phase 1 | Terminated | Washington University School of Medicine | 6 | 2024-03-14 | 2026-09-03 |
| The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN) Epithelioid Hemangioendothelioma, Sarcoma,Soft Tissue | Recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 100 | 2023-12-01 | 2026-04-03 | |
| Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma (SeliSarc) Selinexor 20 MG, Gemcitabine - Sarcoma,Soft Tissue | Phase 2 | Recruiting | Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas | 88 | 2023-09-28 | 2025-06-25 |
| Pembrolizumab in Combination With Eftilagimod Alpha and Radiotherapy in Neoadjuvant Treatment of Patients With Soft Tissue Sarcoma - EFTISARC-NEO Trial Pembrolizumab, Eftilagimod alfa - Neoadjuvant, Immunotherapy | Phase 2 | Active not recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 40 | 2023-07-17 | 2025-12-08 |
| Brachytherapy (Iodine-125 Seeds) and Fluzoparib Combination Therapy for Advanced Unresectable Soft Tissue Sarcoma Fluzoparib, Radioactive particle implantation - Sarcoma,Soft Tissue, Brachytherapy | Phase 2 | Recruiting | Fujun Zhang | 32 | 2023-06-29 | 2025-05-13 |
| PARP Inhibition, Stereotactic Body Radiotherapy and Immunotherapy for Metastatic or Advanced Sarcoma (PRIMA) Camrelizumab and fluzoparib with concurrent stereotactic body radiotherapy (SBRT) - Sarcoma, Sarcoma,Soft Tissue | Phase 2 | Recruiting | Ruijin Hospital | 86 | 2023-06-01 | 2023-10-31 |
| A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma Etrumadenant, Zimberelimab - Dedifferentiated Liposarcoma, Soft Tissue Sarcoma | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 16 | 2023-05-23 | 2026-10-22 |
| A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Bone and Soft Tissue Tumors Recombinant oncolytic herpes simplex virus type Ⅰ (R130) - Osteosarcoma, Sarcoma | Early Phase 1 | Unknown | Shanghai Yunying Medical Technology | 20 | 2023-04-10 | 2023-05-09 |
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Sarcoma (48) · Osteosarcoma (9) · Bone Neoplasms (3) · Chondrosarcoma (3) · Melanoma (3) · Neoplasms (3) · Sarcoma, Synovial (3) · Brain Neoplasms (2) · Breast Neoplasms (2) · Carcinoma, Adenoid Cystic (2) · Liposarcoma (2) · Lymphoma, Follicular (2) · Ovarian Neoplasms (2) · Sarcoma, Ewing (2) · Sarcoma, Kaposi (2)
Neoplasms by Histologic Type (48) · Neoplasms, Connective and Soft Tissue (47) · Neoplasms (45) · Neoplasms, Connective Tissue (12) · Neoplasms, Bone Tissue (10) · Neoplasms by Site (6) · Neoplasms, Glandular and Epithelial (5) · Carcinoma (4) · DNA Virus Infections (4) · Hemic and Lymphatic Diseases (4) · Immune System Diseases (4) · Immunoproliferative Disorders (4) · Infections (4) · Lymphatic Diseases (4) · Lymphoproliferative Disorders (4)
Doxorubicin (3) · Gemcitabine (3) · Radiotherapy (3) · Cyclophosphamide (2) · Ifosfamide (2) · Surgical Procedures, Operative (2) · anlotinib (2) · camrelizumab (2) · fluzoparib (2) · pazopanib (2) · pembrolizumab (2) · selinexor (2) · ADI PEG20 (1) · Biological Therapy (1) · Dacarbazine (1)
Memorial Sloan Kettering Cancer Center (3) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (2) · Centre Leon Berard (2) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (2) · University Health Network, Toronto (2) · Adam Olson (1) · Advenchen Laboratories, LLC (1) · Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas (1) · EpicentRx, Inc. (1) · Essen Biotech (1) · Eye & ENT Hospital of Fudan University (1) · Fujun Zhang (1) · Grupo Espanol de Investigacion en Sarcomas (1) · Hadassah Medical Organization (1) · Helsinki University Central Hospital (1)
United States (16) · China (10) · France (5) · Germany (4) · Italy (4) · Spain (4) · Canada (3) · United Kingdom (3) · Netherlands (2) · Poland (2) · Austria (1) · Denmark (1) · Finland (1) · Israel (1) · Portugal (1)
Sandra D'Angelo, MD (2) · Adam M Olson, MD (1) · Bryan Oronsky, MD PhD (1) · Christian F. Meyer, MD, PhD, MS (1) · Daniel R Santa Mina, PhD (1) · Efstratios Koutroumpakis, MD (1) · Emanuel Stutz, MD (1) · Fujun Zhang, Ph.D,M.D (1) · Fumito Ito, MD (1) · Jennifer Johnson, MD, PhD (1) · Jing Chen, MD, PhD (1)
PMID 18629459, PMID 20130465, PMID 29149611, PMID 33579340, PMID 35950603, PMID 38531939, PMID 39461878, PMID 40146266, PMID 41559089, PMID 8604805
2009 (1), 2019 (1)