1 completed, 1 terminated. 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Completed 1, Terminated 1 |
Follow Refractory Neoplasm: new trials by email Literature Review of Refractory Neoplasm trials Research Report on Refractory Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 9-ING-41 in Pediatric Patients With Refractory Malignancies. 9-ING-41, Irinotecan, Temozolomide - Refractory Cancer, Refractory Neoplasm | Phase 1 | Terminated | Actuate Therapeutics Inc. | 40 | 2020-06-05 | 2025-07-17 |
| Sapanisertib and Metformin in Treating Patients With Advanced or Metastatic Relapsed or Refractory Cancers Laboratory Biomarker Analysis, Metformin, Pharmacological Study - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Completed | M.D. Anderson Cancer Center | 31 | 2018-03-12 | 2023-10-04 |
Neoplasms (2) · Diffuse Intrinsic Pontine Glioma (1) · Meningioma (1) · Neoplasm Metastasis (1) · Neuroblastoma (1)
Brain Diseases (1) · Brain Neoplasms (1) · Brain Stem Neoplasms (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Glioma (1) · Infratentorial Neoplasms (1) · Meningeal Neoplasms (1) · Neoplasms by Histologic Type (1) · Neoplasms by Site (1) · Neoplasms, Germ Cell and Embryonal (1) · Neoplasms, Glandular and Epithelial (1) · Neoplasms, Nerve Tissue (1) · Neoplasms, Neuroepithelial (1) · Neoplasms, Vascular Tissue (1)
3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-f)indol-7-yl)-pyrrole-2,5-dione (1) · Cyclophosphamide (1) · Irinotecan (1) · Metformin (1) · Temozolomide (1) · Topotecan (1) · sapanisertib (1)
Actuate Therapeutics Inc. (1) · M.D. Anderson Cancer Center (1)
United States (2)
Vivek Subbiah (1)
PMID 24327518, PMID 27424289, PMID 28053024, PMID 28672195, PMID 29383130, PMID 29846250, PMID 31101621, PMID 31533931, PMID 31831767, PMID 31882719, PMID 38126764
P30CA016672 (1)