21 completed, 1 terminated. 15 Phase 1, 9 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Completed 15 |
| Phase 2 | 9 | Completed 8, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Refractory Anemia With Excess Blasts in Transformation: new trials by email Literature Review of Refractory Anemia With Excess Blasts in Transformation trials Research Report on Refractory Anemia With Excess Blasts in Transformation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ibrutinib and Azacitidine for Treatment of Higher Risk Myelodysplastic Syndrome Azacitidine, Ibrutinib - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndrome | Phase 1 | Completed | Brian Jonas | 21 | 2016-05-17 | 2022-10-06 |
| DEC-205/NY-ESO-1 Fusion Protein CDX-1401and Decitabine in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Decitabine, Laboratory Biomarker Analysis - Acute Myeloid Leukemia, Alkylating Agent-Related Acute Myeloid Leukemia | Phase 1 | Completed | Roswell Park Cancer Institute | 9 | 2013-07-30 | 2022-07-22 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia laboratory biomarker analysis - Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7) | Completed | Children's Oncology Group | 20 | 2009-05-01 | 2016-05-17 | |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia filgrastim, busulfan, cyclosporine - Leukemia, Myelodysplastic Syndromes | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 34 | 2005-11-01 | 2025-08-26 |
| SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes ispinesib, laboratory biomarker analysis, pharmacological study - Acute Undifferentiated Leukemia, Adult Acute Megakaryoblastic Leukemia (M7) | Phase 1 | Completed | National Cancer Institute (NCI) | 40 | 2004-12-01 | 2013-01-11 |
| Tanespimycin and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Chronic Myelomonocytic Leukemia, or Myelodysplastic Syndromes tanespimycin, cytarabine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2004-11-01 | 2013-09-30 |
| XK469R in Treating Patients With Refractory Hematologic Cancer R(+)XK469, pharmacological study, laboratory biomarker analysis - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 60 | 2004-10-01 | 2013-02-08 |
| Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia cytarabine, idarubicin, tipifarnib - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 95 | 2004-09-01 | 2014-05-26 |
| Rebeccamycin Analog in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia becatecarin, laboratory biomarker analysis - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 1 | Completed | National Cancer Institute (NCI) | 40 | 2004-05-01 | 2013-01-23 |
| CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase temsirolimus, laboratory biomarker analysis - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 2 | Completed | National Cancer Institute (NCI) | 74 | 2004-04-01 | 2013-01-23 |
| Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Total Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome iodine I 131 monoclonal antibody BC8, fludarabine phosphate, total-body irradiation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 18 | 2003-05-01 | 2022-12-12 |
| Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation therapeutic allogeneic lymphocytes, aldesleukin, peripheral blood stem cell transplantation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2002-09-01 | 2017-03-29 |
| Tipifarnib in Treating Patients With Myelodysplastic Syndromes tipifarnib, laboratory biomarker analysis, pharmacological study - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 | Completed | National Cancer Institute (NCI) | 65 | 2002-06-01 | 2013-12-16 |
| Thalidomide in Treating Patients With Myelodysplastic Syndrome thalidomide, laboratory biomarker analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 2 | Completed | National Cancer Institute (NCI) | 29 | 2001-04-01 | 2013-01-24 |
| BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia BMS-214662, pharmacological study, laboratory biomarker analysis - Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2000-04-01 | 2013-01-23 |
| Liposomal Daunorubicin and SU5416 in Treating Patients With Hematologic Cancer That Has Not Responded to Initial Therapy liposomal daunorubicin citrate, semaxanib, laboratory biomarker analysis - Chronic Myelomonocytic Leukemia, Previously Treated Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 37 | 2000-03-01 | 2013-01-23 |
| PS-341 in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia in Blast Phase, or Myelodysplastic Syndrome bortezomib - Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2000-02-01 | 2013-01-23 |
| Vaccine Therapy Plus Immune Adjuvant in Treating Patients With Chronic Myeloid Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome PR1 leukemia peptide vaccine, Montanide ISA 51 VG, sargramostim - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 69 | 1999-12-01 | 2013-01-07 |
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Anemia, Refractory, with Excess of Blasts (19) · Leukemia, Myelomonocytic, Chronic (15) · Leukemia, Myeloid, Acute (13) · Congenital Abnormalities (11) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (9) · Anemia, Refractory (7) · Blast Crisis (7) · Leukemia, Erythroblastic, Acute (4) · Leukemia, Megakaryoblastic, Acute (4) · Leukemia, Monocytic, Acute (4) · Leukemia, Myeloid, Accelerated Phase (4) · Leukemia, Myelomonocytic, Acute (4) · Leukemia, Basophilic, Acute (3) · Leukemia, Eosinophilic, Acute (3) · Leukemia, Myeloid, Chronic-Phase (3)
Bone Marrow Diseases (22) · Hematologic Diseases (22) · Hemic and Lymphatic Diseases (22) · Neoplasms (22) · Neoplasms by Histologic Type (22) · Chronic Disease (21) · Disease Attributes (21) · Leukemia (21) · Leukemia, Myeloid (21) · Pathologic Processes (21) · Pathological Conditions, Signs and Symptoms (21) · Anemia (19) · Myelodysplastic Syndromes (18) · Myelodysplastic-Myeloproliferative Diseases (15) · Anemia, Refractory (12)
fludarabine phosphate (6) · Cyclosporine (5) · Mycophenolic Acid (5) · Cyclophosphamide (3) · Cytarabine (3) · Peripheral Blood Stem Cell Transplantation (3) · Transplantation (3) · Whole-Body Irradiation (3) · Busulfan (2) · Cord Blood Stem Cell Transplantation (2) · Daunorubicin (2) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2) · Idarubicin (2) · Immunologic Techniques (2)
National Cancer Institute (NCI) (13) · Fred Hutchinson Cancer Center (4) · Brian Jonas (1) · Children's Oncology Group (1) · Masonic Cancer Center, University of Minnesota (1) · Nohla Therapeutics, Inc. (1) · Roswell Park Cancer Institute (1)
United States (22)
Francis Giles (4) · Jorge Cortes (3) · Colleen Delaney (2) · Johnnie Orozco (2) · Alvaro Moreno Aspitia (1) · Beverly Lange (1) · Brenda Cooper (1) · Brian Jonas (1) · Christen Ebens, MD (1) · Elizabeth Griffiths (1) · Merav Bar (1) · Monica Thakar, MD (1) · Muzaffar Qazilbash (1) · Razelle Kurzrock (1) · Scott Kaufmann (1)
PMID 19304957, PMID 19786617, PMID 20056794, PMID 20413658, PMID 21791475, PMID 35445027, PMID 36815378, PMID 38295280, PMID 42085603
U01CA062461 (4), P30CA015704 (3), N01CM62202 (2), RC2HL101844 (2), P01CA018029 (1), P01CA044991 (1), R24HL074445 (1), R43HL106868 (1), U01CA062502 (1), U01CA062505 (1), U01CA069912 (1), U01CA070095 (1), U10CA025224 (1), U10CA098543 (1)