41 completed, 7 terminated, 5 unknown, 2 active not recruiting. 22 Phase 1, 20 Phase 2, 7 Phase 3, 1 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 17, Terminated 5 |
| Phase 2 | 20 | Completed 14, Unknown 3, Terminated 2, Active not recruiting 1 |
| Phase 3 | 7 | Completed 6, Unknown 1 |
| Not applicable | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Leukemia, Basophilic, Acute: new trials by email Literature Review of Leukemia, Basophilic, Acute trials Research Report on Leukemia, Basophilic, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy eltrombopag olamine - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia | Phase 2 | Completed | Case Comprehensive Cancer Center | 31 | 2014-08-14 | 2026-08-07 |
| Eltrombopag Olamine in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia eltrombopag olamine, standard follow-up care - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 | Terminated | Roswell Park Cancer Institute | 10 | 2012-05-01 | 2022-07-22 |
| S0106B Studying Bone Marrow Samples From Women With Acute Myeloid Leukemia gene expression analysis, flow cytometry, fluorescence activated cell sorting - Leukemia | Completed | SWOG Cancer Research Network | 100 | 2012-04-01 | 2015-03-06 | |
| Biomarkers in Blood Samples From Patients With Acute Myeloid Leukemia mutation analysis, protein analysis, laboratory biomarker analysis - Leukemia | Completed | Eastern Cooperative Oncology Group | 220 | 2012-01-03 | 2017-05-19 | |
| Decitabine, Cytarabine, and Daunorubicin Hydrochloride in Treating Patients With Acute Myeloid Leukemia Cytarabine, Daunorubicin Hydrochloride, Decitabine - Acute Myeloid Leukemia, Adult Acute Basophilic Leukemia | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 178 | 2011-09-16 | 2026-04-27 |
| Biomarkers in Samples From Adult Patients With Acute Myeloid Leukemia Who Failed Existing Standard-of-Care Treatment DNA methylation analysis, RNA analysis, gene expression analysis - Leukemia | Unknown | National Cancer Institute (NCI) | 400 | 2011-09-01 | 2013-07-10 | |
| Study of Gemtuzumab Ozogamicin Therapy in DNA Samples From Patients With Acute Myeloid Leukemia Treated on COG-AAML0531 DNA analysis, gene expression analysis, laboratory biomarker analysis - Leukemia | Completed | Children's Oncology Group | 1000 | 2011-07-01 | 2016-05-19 | |
| S0106A, Biomarkers in Samples From Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With Cytarabine-Based Chemotherapy proteomic profiling, flow cytometry, laboratory biomarker analysis - Leukemia | Completed | SWOG Cancer Research Network | 310 | 2011-06-01 | 2016-04-15 | |
| Azacitidine, Mitoxantrone Hydrochloride, and Etoposide in Treating Older Patients With Poor-Prognosis Acute Myeloid Leukemia Azacitidine, Etoposide, Laboratory Biomarker Analysis - Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Adult Acute Basophilic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 13 | 2010-12-01 | 2015-08-20 |
| Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy standard follow-up care, medical chart review, quality-of-life assessment - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Phase 2 | Completed | Fred Hutchinson Cancer Center | 200 | 2010-12-01 | 2020-07-31 |
| Everolimus MICE-regimen in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia cytarabine, etoposide, everolimus - Leukemia | Phase 1 | Completed | Gruppo Italiano Malattie EMatologiche dell'Adulto | 11 | 2010-10-01 | 2022-10-26 |
| Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid Tumors or Refractory or Relapsed Acute Myeloid Leukemia entinostat, sorafenib tosylate, pharmacological study - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 44 | 2010-06-01 | 2013-09-19 |
| Clofarabine and Temsirolimus in Treating Older Patients With Relapsed or Refractory Acute Myeloid Leukemia clofarabine, temsirolimus - Leukemia | Phase 2 | Completed | Gruppo Italiano Malattie EMatologiche dell'Adulto | 60 | 2008-12-01 | 2017-11-09 |
| Early Discharge and Outpatient Care After Chemotherapy in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia medical chart review, questionnaire administration, quality-of-life assessment - Leukemia, Myelodysplastic Syndromes | Not applicable | Completed | Fred Hutchinson Cancer Center | 96 | 2008-12-01 | 2011-05-19 |
| Imatinib Mesylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Who Have Received Chemotherapy imatinib mesylate, gene expression analysis, mutation analysis - Leukemia | Phase 2 | Completed | Case Comprehensive Cancer Center | 32 | 2008-10-01 | 2020-03-17 |
| Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia cytarabine, daunorubicin, midostaurin - Leukemia | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 717 | 2008-04-01 | 2026-10-21 |
| Tipifarnib, Cytarabine, and Daunorubicin in Treating Older Patients With Acute Myeloid Leukemia cytarabine, daunorubicin hydrochloride, tipifarnib - Leukemia | Phase 1 | Completed | University Health Network, Toronto | 24 | 2007-04-01 | 2015-07-23 |
| Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia alvocidib, cytarabine, mitoxantrone hydrochloride - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2006-10-01 | 2015-08-04 |
| Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia gene expression analysis, molecular genetic technique, polymorphism analysis - Leukemia | Active not recruiting | Alliance for Clinical Trials in Oncology | 600 | 2006-10-01 | 2023-08-18 | |
| Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia asparaginase, cytarabine, daunorubicin hydrochloride - Leukemia | Phase 3 | Completed | Children's Oncology Group | 1070 | 2006-08-01 | 2021-03-24 |
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Leukemia, Myeloid, Acute (55) · Leukemia, Eosinophilic, Acute (54) · Leukemia, Erythroblastic, Acute (53) · Leukemia, Megakaryoblastic, Acute (53) · Leukemia, Monocytic, Acute (53) · Leukemia, Myelomonocytic, Acute (53) · Congenital Abnormalities (43) · Leukemia (34) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (18) · Blast Crisis (14) · Leukemia, Lymphocytic, Chronic, B-Cell (8) · Leukemia, Myeloid, Accelerated Phase (8) · Leukemia, Myelomonocytic, Chronic (8) · Leukemia, Promyelocytic, Acute (8)
Hematologic Diseases (55) · Hemic and Lymphatic Diseases (55) · Leukemia, Myeloid (55) · Neoplasms (55) · Neoplasms by Histologic Type (55) · Bone Marrow Diseases (54) · Myeloproliferative Disorders (50) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (43) · Leukemia (21) · Immune System Diseases (18) · Immunoproliferative Disorders (18) · Leukemia, Lymphoid (18) · Lymphatic Diseases (18) · Lymphoproliferative Disorders (18) · Chronic Disease (17)
Cytarabine (22) · Daunorubicin (8) · Etoposide (6) · Filgrastim (6) · Gene Expression Profiling (6) · Idarubicin (6) · Clofarabine (5) · Gemtuzumab (5) · tipifarnib (5) · Cyclophosphamide (4) · Mitoxantrone (4) · Peripheral Blood Stem Cell Transplantation (4) · Arsenic Trioxide (3) · Busulfan (3) · Flow Cytometry (3)
National Cancer Institute (NCI) (20) · SWOG Cancer Research Network (4) · Alliance for Clinical Trials in Oncology (3) · Fred Hutchinson Cancer Center (3) · Case Comprehensive Cancer Center (2) · Children's Oncology Group (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Gruppo Italiano Malattie EMatologiche dell'Adulto (2) · Roswell Park Cancer Institute (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · University of Maryland, Baltimore (2) · Vion Pharmaceuticals (2) · Wake Forest University Health Sciences (2) · City of Hope Medical Center (1) · Eastern Cooperative Oncology Group (1)
United States (42) · Canada (6) · Italy (4) · Belgium (3) · France (3) · Netherlands (3) · United Kingdom (3) · Switzerland (2) · Australia (1) · Croatia (1) · Germany (1) · Greece (1) · New Zealand (1) · Poland (1) · Portugal (1)
Sergio Amadori, MD (3) · Barry R. Meisenberg, MD (2) · Bayard L. Powell, MD (2) · Bonny L. Johnson, RN, MSN (2) · Jerry Radich, MD (2) · Jorge Cortes (2) · Judith E. Karp, MD (2) · Judith Karp (2) · Roland Walter, MD, PhD (2) · Srdan Verstovsek (2) · Stephen H. Petersdorf, MD (2) · Alan K. Burnett, MD, FRCP (1) · Alan S. Gamis, MD, MPH (1) · Alex Adjei (1) · Anjali Advani, MD (1)
PMID 24383844, PMID 25527568, PMID 31375516, PMID 36184192, PMID 37267439, PMID 17562873, PMID 17640728, PMID 18571721, PMID 19092853, PMID 19710500, PMID 20460644, PMID 20522709, PMID 20952518, PMID 21393334, PMID 21551228, PMID 21791475, PMID 22627678, PMID 22733022, PMID 23256542, PMID 23471307, PMID 23591789, PMID 25092781, PMID 26811524, PMID 27133823, PMID 28411282, PMID 28644114, PMID 28883080, PMID 30382485, PMID 31171508, PMID 31182436, PMID 33049054, PMID 33080007, PMID 34048275, PMID 34596937, PMID 36815378, PMID 37534515, PMID 38295280, PMID 40294366, PMID 42085603
U01CA070095 (5), U10CA032102 (5), P30CA006973 (3), U10CA031946 (3), N01CM62202 (2), N01CM62204 (2), P30CA016672 (2), U01CA076576 (2), U10CA180821 (2), 2008 (1), N01CM00032 (1), N01CM00070 (1), N01CM62203 (1), N01CM62208 (1), P30CA015704 (1)