14 completed, 3 terminated. 17 Phase 2, 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 14, Terminated 3 |
| Phase 1 | 6 | Completed 5, Terminated 1 |
Follow Refractory Anemia With Excess Blasts: new trials by email Literature Review of Refractory Anemia With Excess Blasts trials Research Report on Refractory Anemia With Excess Blasts
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Fludarabine, Total-Body Irradiation, T Cell-Depleted Donor Lymphocyte Infusion - Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 35 | 2015-11-13 | 2025-04-24 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Decitabine Followed by Idarubicin and Cytarabine in Treating Patients With Relapsed or Refractory AML and MDS decitabine, idarubicin, cytarabine - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a) | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 7 | 2012-07-01 | 2017-03-31 |
| Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm filgrastim, clofarabine, cytarabine - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Completed | University of Washington | 50 | 2010-08-01 | 2017-10-19 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome flow cytometry, DNA methylation analysis, cytogenetic analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2010-07-01 | 2019-03-04 |
| Busulfan, Etoposide, and Intensity-Modulated Radiation Therapy Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Myeloid Cancer busulfan, etoposide, intensity-modulated radiation therapy - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 1 / Phase 2 | Terminated | City of Hope Medical Center | 25 | 2007-06-11 | 2023-11-30 |
| MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic Leukemia entinostat, sargramostim - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7) | Phase 2 | Completed | National Cancer Institute (NCI) | 24 | 2007-04-01 | 2017-07-18 |
| Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders Cyclosporine, Fludarabine Phosphate, Laboratory Biomarker Analysis - Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Chronic Myelomonocytic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 77 | 2006-01-01 | 2020-01-31 |
| Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia filgrastim, busulfan, cyclosporine - Leukemia, Myelodysplastic Syndromes | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 34 | 2005-11-01 | 2025-08-26 |
| Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia cytarabine, idarubicin, tipifarnib - Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 95 | 2004-09-01 | 2014-05-26 |
| CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase temsirolimus, laboratory biomarker analysis - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 2 | Completed | National Cancer Institute (NCI) | 74 | 2004-04-01 | 2013-01-23 |
| Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Total Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome iodine I 131 monoclonal antibody BC8, fludarabine phosphate, total-body irradiation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 18 | 2003-05-01 | 2022-12-12 |
| Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation therapeutic allogeneic lymphocytes, aldesleukin, peripheral blood stem cell transplantation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2002-09-01 | 2017-03-29 |
| Thalidomide in Treating Patients With Myelodysplastic Syndrome thalidomide, laboratory biomarker analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 2 | Completed | National Cancer Institute (NCI) | 29 | 2001-04-01 | 2013-01-24 |
| Liposomal Daunorubicin and SU5416 in Treating Patients With Hematologic Cancer That Has Not Responded to Initial Therapy liposomal daunorubicin citrate, semaxanib, laboratory biomarker analysis - Chronic Myelomonocytic Leukemia, Previously Treated Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 37 | 2000-03-01 | 2013-01-23 |
| Vaccine Therapy Plus Immune Adjuvant in Treating Patients With Chronic Myeloid Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome PR1 leukemia peptide vaccine, Montanide ISA 51 VG, sargramostim - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 69 | 1999-12-01 | 2013-01-07 |
Anemia, Refractory, with Excess of Blasts (17) · Leukemia, Myelomonocytic, Chronic (12) · Congenital Abnormalities (10) · Leukemia, Myeloid, Acute (10) · Anemia, Refractory (8) · Myeloproliferative Disorders (4) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (4) · Leukemia, Erythroblastic, Acute (3) · Leukemia, Megakaryoblastic, Acute (3) · Leukemia, Monocytic, Acute (3) · Leukemia, Myeloid, Accelerated Phase (3) · Leukemia, Myeloid, Chronic-Phase (3) · Leukemia, Myelomonocytic, Acute (3) · Myelodysplastic Syndromes (3) · Blast Crisis (2)
Anemia (17) · Bone Marrow Diseases (17) · Hematologic Diseases (17) · Hemic and Lymphatic Diseases (17) · Neoplasms by Histologic Type (17) · Leukemia (16) · Leukemia, Myeloid (16) · Neoplasms (16) · Chronic Disease (15) · Disease Attributes (15) · Pathologic Processes (15) · Pathological Conditions, Signs and Symptoms (15) · Myelodysplastic Syndromes (14) · Myelodysplastic-Myeloproliferative Diseases (12) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10)
Cyclosporine (5) · Mycophenolic Acid (5) · Peripheral Blood Stem Cell Transplantation (5) · fludarabine phosphate (5) · Whole-Body Irradiation (4) · Cytarabine (3) · Transplantation (3) · Busulfan (2) · Cord Blood Stem Cell Transplantation (2) · Cyclophosphamide (2) · Cytogenetic Analysis (2) · Decitabine (2) · Filgrastim (2) · Flow Cytometry (2) · Gene Expression Profiling (2)
National Cancer Institute (NCI) (7) · Fred Hutchinson Cancer Center (4) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · Masonic Cancer Center, University of Minnesota (1) · Nohla Therapeutics, Inc. (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University of Washington (1)
United States (17)
Francis Giles (2) · Alvaro Moreno Aspitia (1) · Anthony Stein (1) · B. Smith (1) · Brenda Cooper, MD (1) · Brenda Sandmaier (1) · Christen Ebens, MD (1) · Colleen Delaney (1) · Derek Stirewalt (1) · Johnnie Orozco (1) · Jorge Cortes (1) · Merav Bar (1) · Muzaffar Qazilbash (1) · Pamela Becker (1) · Pavan Reddy (1)
PMID 25545153, PMID 25621498, PMID 30630975, PMID 32499241, PMID 35445027
P30CA015704 (4), N01CM62202 (2), P01CA018029 (2), P30CA046592 (1), RC2HL101844 (1), U01CA070095 (1), U10CA025224 (1)