31 completed, 5 terminated. 19 Phase 1, 17 Phase 2, 3 Phase 3, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 17, Terminated 2 |
| Phase 2 | 17 | Completed 14, Terminated 3 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Not applicable | 2 | Completed 2 |
Follow Refractory Anemia With Excess Blasts: new trials by email Literature Review of Refractory Anemia With Excess Blasts trials Research Report on Refractory Anemia With Excess Blasts
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Controlled Study of Rigosertib Versus Physician's Choice of Treatment in MDS Patients After Failure of an HMA rigosertib, Any approved or standard-of-care therapy, best supportive care (BSC) - Myelodysplastic Syndrome, MDS | Phase 3 | Terminated | Traws Pharma, Inc. | 372 | 2015-12-02 | 2022-09-26 |
| Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Fludarabine, Total-Body Irradiation, T Cell-Depleted Donor Lymphocyte Infusion - Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 35 | 2015-11-13 | 2025-04-24 |
| Treatment for Relapsed/Refractory AML Based on a High Throughput Drug Sensitivity Assay antitumor drug screening assay, chemotherapy, biological therapy - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Not applicable | Completed | University of Washington | 16 | 2013-08-02 | 2018-07-11 |
| Efficacy and Safety of IV Rigosertib in MDS Patients With Excess Blasts Progressing After Azacitidine or Decitabine rigosertib sodium - Myelodysplastic Syndromes, Refractory Anemia With Excess Blasts | Phase 3 | Completed | Traws Pharma, Inc. | 67 | 2013-08-01 | 2020-06-30 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes pravastatin sodium, idarubicin, cytarabine - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Not applicable | Completed | Fred Hutchinson Cancer Center | 24 | 2013-05-01 | 2017-11-17 |
| Decitabine Followed by Idarubicin and Cytarabine in Treating Patients With Relapsed or Refractory AML and MDS decitabine, idarubicin, cytarabine - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a) | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 7 | 2012-07-01 | 2017-03-31 |
| Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine - Chronic Myelomonocytic Leukemia, Previously Treated Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 16 | 2012-01-01 | 2019-12-10 |
| Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm filgrastim, clofarabine, cytarabine - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Completed | University of Washington | 50 | 2010-08-01 | 2017-10-19 |
| Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies umbilical cord blood transplantation, fludarabine phosphate, cyclophosphamide - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | Nohla Therapeutics, Inc. | 15 | 2010-08-01 | 2019-03-05 |
| Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome flow cytometry, DNA methylation analysis, cytogenetic analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2010-07-01 | 2019-03-04 |
| Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome Pretargeted Radioimmunotherapy, Cyclosporine, Mycophenolate Mofetil - Chronic Myelomonocytic Leukemia, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable | Phase 1 | Completed | Fred Hutchinson Cancer Center | 17 | 2010-04-21 | 2017-08-30 |
| Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia laboratory biomarker analysis - Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7) | Completed | Children's Oncology Group | 20 | 2009-05-01 | 2016-05-17 | |
| Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Syndrome Allogeneic Bone Marrow Transplantation, Cyclophosphamide, Fludarabine Phosphate - Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Terminated | Fred Hutchinson Cancer Center | 26 | 2007-10-05 | 2023-02-09 |
| Busulfan, Etoposide, and Intensity-Modulated Radiation Therapy Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Myeloid Cancer busulfan, etoposide, intensity-modulated radiation therapy - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 1 / Phase 2 | Terminated | City of Hope Medical Center | 25 | 2007-06-11 | 2023-11-30 |
| MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic Leukemia entinostat, sargramostim - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7) | Phase 2 | Completed | National Cancer Institute (NCI) | 24 | 2007-04-01 | 2017-07-18 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Flavopiridol and Vorinostat in Treating Patients With Relapsed or Refractory Acute Leukemia or Chronic Myelogenous Leukemia or Refractory Anemia alvocidib, vorinostat - Blastic Phase Chronic Myelogenous Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2006-01-01 | 2013-04-02 |
| Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders Cyclosporine, Fludarabine Phosphate, Laboratory Biomarker Analysis - Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Chronic Myelomonocytic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 77 | 2006-01-01 | 2020-01-31 |
| Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia filgrastim, busulfan, cyclosporine - Leukemia, Myelodysplastic Syndromes | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 34 | 2005-11-01 | 2025-08-26 |
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Anemia, Refractory, with Excess of Blasts (36) · Leukemia, Myelomonocytic, Chronic (24) · Leukemia, Myeloid, Acute (21) · Congenital Abnormalities (17) · Anemia, Refractory (13) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (13) · Blast Crisis (8) · Leukemia, Erythroblastic, Acute (7) · Leukemia, Megakaryoblastic, Acute (7) · Leukemia, Monocytic, Acute (7) · Leukemia, Myelomonocytic, Acute (7) · Myeloproliferative Disorders (7) · Myelodysplastic Syndromes (5) · Leukemia, Myeloid, Accelerated Phase (4) · Leukemia, Myeloid, Chronic-Phase (4)
Anemia (36) · Bone Marrow Diseases (36) · Hematologic Diseases (36) · Hemic and Lymphatic Diseases (36) · Neoplasms by Histologic Type (34) · Leukemia (33) · Leukemia, Myeloid (33) · Neoplasms (33) · Chronic Disease (32) · Disease Attributes (32) · Pathologic Processes (32) · Pathological Conditions, Signs and Symptoms (32) · Myelodysplastic Syndromes (31) · Myelodysplastic-Myeloproliferative Diseases (24) · Anemia, Refractory (23)
fludarabine phosphate (11) · Mycophenolic Acid (10) · Cyclosporine (9) · Peripheral Blood Stem Cell Transplantation (8) · Whole-Body Irradiation (8) · Cyclophosphamide (5) · Cytarabine (5) · Idarubicin (4) · Transplantation (4) · Busulfan (3) · Cyclosporins (3) · Filgrastim (3) · Granulocyte Colony-Stimulating Factor (3) · Tacrolimus (3) · Cord Blood Stem Cell Transplantation (2)
National Cancer Institute (NCI) (16) · Fred Hutchinson Cancer Center (10) · Traws Pharma, Inc. (2) · University of Washington (2) · Case Comprehensive Cancer Center (1) · Children's Oncology Group (1) · City of Hope Medical Center (1) · Masonic Cancer Center, University of Minnesota (1) · Nohla Therapeutics, Inc. (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1)
United States (36) · Australia (2) · France (2) · Germany (2) · Italy (2) · Spain (2) · Sweden (2) · Austria (1) · Belgium (1) · Canada (1) · Croatia (1) · Czechia (1) · Denmark (1) · Estonia (1) · Hungary (1)
Francis Giles (4) · Brenda Sandmaier (3) · Johnnie Orozco (3) · Jorge Cortes (3) · Colleen Delaney (2) · Pamela Becker (2) · Steven M. Fruchtman, MD (2) · Alvaro Moreno Aspitia (1) · Anthony Stein (1) · B. Smith (1) · Beverly Lange (1) · Brenda Cooper (1) · Brenda Cooper, MD (1) · Christen Ebens, MD (1) · Derek Stirewalt (1)
PMID 19304957, PMID 19786617, PMID 20056794, PMID 20413658, PMID 21149673, PMID 25545153, PMID 25621498, PMID 30630975, PMID 31582553, PMID 32499241, PMID 35445027, PMID 36815378, PMID 37939122, PMID 38295280, PMID 42085603
P30CA015704 (9), P01CA044991 (4), U01CA062461 (4), N01CM62202 (2), P01CA018029 (2), RC2HL101844 (2), 2015 (1), P30CA046592 (1), R21CA115260 (1), R24HL074445 (1), R43HL106868 (1), U01CA062490 (1), U01CA062502 (1), U01CA062505 (1), U01CA070095 (1)