20 completed, 6 terminated, 3 withdrawn. 11 Phase 1, 10 Phase 2, 7 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 8, Terminated 2, Withdrawn 1 |
| Phase 2 | 10 | Completed 7, Terminated 3 |
| Not applicable | 7 | Completed 4, Withdrawn 2, Terminated 1 |
Follow Recurrent Ovarian Germ Cell Tumor: new trials by email Literature Review of Recurrent Ovarian Germ Cell Tumor trials Research Report on Recurrent Ovarian Germ Cell Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer metformin hydrochloride, placebo, Chemotherapy - Brenner Tumor, Malignant Ascites | Phase 2 | Completed | University of Chicago | 111 | 2015-02-25 | 2026-03-27 |
| Palliative Care in Improving Quality of Life and Symptoms in Patients With Stage III-IV Pancreatic or Ovarian Cancer palliative care, educational intervention, quality-of-life assessment - Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor | Not applicable | Withdrawn | City of Hope Medical Center | 2014-12-01 | 2014-12-23 | |
| Everolimus and Letrozole in Treating Patients With Recurrent Hormone Receptor Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer Everolimus, Laboratory Biomarker Analysis, Letrozole - Ovarian Endometrioid Adenocarcinoma, Ovarian Seromucinous Carcinoma | Phase 2 | Completed | Mayo Clinic | 20 | 2014-11-14 | 2020-10-23 |
| Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers educational intervention, telephone-based intervention, quality-of-life assessment - Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter | Not applicable | Completed | City of Hope Medical Center | 200 | 2013-10-29 | 2026-10-01 |
| Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors palifosfamide - Adult Central Nervous System Germ Cell Tumor, Adult Teratoma | Phase 2 | Terminated | Indiana University | 5 | 2013-02-01 | 2015-07-02 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer stereotactic body radiation therapy, carboplatin, gemcitabine hydrochloride - Leydig Cell Tumor, Ovarian Sarcoma | Phase 1 | Completed | Case Comprehensive Cancer Center | 12 | 2012-05-01 | 2015-08-04 |
| Phase I Stereotactic Body Radiation for Metastatic or Recurrent Platinum-Resistant Ovarian Cancer stereotactic body radiation therapy, positron emission tomography, computed tomography - Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor | Phase 1 | Terminated | Stanford University | 1 | 2012-04-01 | 2017-04-28 |
| Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors veliparib, capecitabine, oxaliplatin - Adenocarcinoma of the Pancreas, Adenocarcinoma of the Stomach | Phase 1 | Terminated | National Cancer Institute (NCI) | 16 | 2010-10-01 | 2014-04-02 |
| Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer questionnaire administration, quality-of-life assessment, psychosocial assessment and care - Anxiety Disorder, Depression | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 39 | 2010-10-01 | 2015-10-09 |
| Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload deferasirox - Iron Overload, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2010-07-01 | 2019-06-18 |
| Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors temsirolimus, vinorelbine ditartrate - Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma | Phase 1 | Completed | University of Southern California | 19 | 2010-06-01 | 2016-06-13 |
| Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2010-05-01 | 2014-12-23 |
| Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) HIPEC Orientation, Consultation with Survivorship Navigator, Questionnaires - Advanced Malignant Mesothelioma, Carcinoma of the Appendix | Not applicable | Completed | Wake Forest University Health Sciences | 10 | 2010-05-01 | 2018-07-03 |
| Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer PD-0332991 - Adult Solid Tumor, Adenocarcinoma of the Colon | Phase 2 | Completed | Abramson Cancer Center at Penn Medicine | 304 | 2009-10-01 | 2021-03-11 |
| Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Alvocidib Hydrochloride, Fluorouracil, Leucovorin Calcium - Recurrent Extragonadal Seminoma, Recurrent Malignant Extragonadal Germ Cell Tumor | Phase 2 | Completed | National Cancer Institute (NCI) | 36 | 2009-06-01 | 2017-03-10 |
| Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies stereotactic radiosurgery, quality-of-life assessment - Fallopian Tube Cancer, Ovarian Sarcoma | Phase 2 | Completed | Case Comprehensive Cancer Center | 50 | 2009-05-01 | 2013-11-28 |
| Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant ondansetron, survey administration, management of therapy complications - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 49 | 2008-08-08 | 2017-05-23 |
| Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Carboplatin, Filgrastim, Ifosfamide - Childhood Extracranial Germ Cell Tumor, Childhood Extragonadal Malignant Germ Cell Tumor | Phase 2 | Completed | Children's Oncology Group | 20 | 2007-11-05 | 2018-08-29 |
| Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor busulfan, melphalan, topotecan hydrochloride - Solid Tumor, Adult Central Nervous System Germ Cell Tumor | Phase 1 | Completed | City of Hope Medical Center | 25 | 2007-02-26 | 2025-03-20 |
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Carcinoma, Ovarian Epithelial (20) · Breast Neoplasms (12) · Testicular Neoplasms (11) · Fallopian Tube Neoplasms (8) · Colonic Neoplasms (7) · Uterine Cervical Neoplasms (7) · Endometrial Neoplasms (6) · Neuroblastoma (6) · Pancreatic Neoplasms (6) · Rectal Neoplasms (6) · Burkitt Lymphoma (5) · Carcinoma, Non-Small-Cell Lung (5) · Congenital Abnormalities (5) · Hodgkin Disease (5) · Leukemia, Lymphocytic, Chronic, B-Cell (5)
Endocrine Gland Neoplasms (29) · Endocrine System Diseases (29) · Genital Diseases (29) · Gonadal Disorders (29) · Neoplasms by Site (29) · Urogenital Diseases (29) · Urogenital Neoplasms (29) · Neoplasms (28) · Neoplasms by Histologic Type (27) · Female Urogenital Diseases (24) · Female Urogenital Diseases and Pregnancy Complications (24) · Adnexal Diseases (23) · Genital Diseases, Female (23) · Genital Neoplasms, Female (23) · Neoplasms, Glandular and Epithelial (23)
Carboplatin (4) · Early Intervention, Educational (3) · Methods (3) · Paclitaxel (3) · Radiosurgery (3) · Taxes (3) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2) · Ifosfamide (2) · Metformin (2) · Oxaliplatin (2) · Sirolimus (2) · temsirolimus (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1)
National Cancer Institute (NCI) (8) · City of Hope Medical Center (4) · Case Comprehensive Cancer Center (2) · Fred Hutchinson Cancer Center (2) · Abramson Cancer Center at Penn Medicine (1) · Children's Oncology Group (1) · Fox Chase Cancer Center (1) · Gynecologic Oncology Group (1) · Indiana University (1) · Mayo Clinic (1) · Ohio State University Comprehensive Cancer Center (1) · Roswell Park Cancer Institute (1) · Stanford University (1) · University of Chicago (1) · University of Southern California (1)
United States (26) · Canada (3) · Australia (1) · Puerto Rico (1)
Agustin Garcia (1) · Amit Oza (1) · Angela Jain (1) · Anna Pawlowska, MD (1) · Barbara Andersen, PhD (1) · Betty Ferrell (1) · Carlos Rodriguez-Galindo (1) · Christopher Ryan (1) · Darren Feldman (1) · Elizabeth Kidd (1) · Ewa Carrier (1) · Gerardo Colon-Otero (1) · Lawrence H Einhorn, MD (1) · Leona Holmberg (1) · Mary Disis (1)
PMID 18974373, PMID 28817727, PMID 32641862, PMID 32692450
U01CA062491 (2), N01CM00071 (1), N01CM62206 (1), P01CA087971 (1), P30CA006927 (1), P30CA008748 (1), P30CA014520 (1), P30CA015083 (1), P30CA033572 (1), P30CA044579 (1), R01CA093891 (1), R21CA135005 (1), U01CA062505 (1), U01CA069856 (1), U01CA069912 (1)