9 completed, 6 terminated, 2 withdrawn, 1 active not recruiting. 18 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 9, Terminated 6, Withdrawn 2, Active not recruiting 1 |
| Phase 2 | 4 | Completed 2, Terminated 2 |
Follow Recurrent Non-Small Cell Lung Carcinoma: new trials by email Literature Review of Recurrent Non-Small Cell Lung Carcinoma trials Research Report on Recurrent Non-Small Cell Lung Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nimotuzumab and Nivolumab in Treating Patients With Advanced Non-small Cell Lung Cancer Laboratory Biomarker Analysis, Nimotuzumab, Nivolumab - EGFR Gene Mutation, Recurrent Non-Small Cell Lung Carcinoma | Phase 1 | Completed | Roswell Park Cancer Institute | 7 | 2017-06-29 | 2023-10-05 |
| Nivolumab and Plinabulin in Treating Patients With Stage IIIB-IV, Recurrent, or Metastatic Non-small Cell Lung Cancer Nivolumab, Plinabulin - ALK Gene Translocation, EGFR Activating Mutation | Phase 1 / Phase 2 | Terminated | University of Washington | 5 | 2017-06-14 | 2019-03-04 |
| Binimetinib With Docetaxel in Treating Patients With Previously Treated, Stage IV Non-small Cell Lung Cancer Binimetinib, Docetaxel, Laboratory Biomarker Analysis - Recurrent Non-Small Cell Lung Carcinoma, Stage IV Non-Small Cell Lung Cancer | Phase 1 | Withdrawn | Jonsson Comprehensive Cancer Center | 2016-06-01 | 2020-07-24 | |
| TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic, Persistent, Recurrent, or Progressive Solid Tumors Cyclophosphamide, Laboratory Biomarker Analysis, Pegfilgrastim - Colorectal Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 1 | Terminated | Mayo Clinic | 4 | 2016-02-05 | 2018-09-05 |
| MPDL3280A and Stereotactic Ablative Radiotherapy in Patients With Non-small Cell Lung Cancer Anti-PD-L1 Monoclonal Antibody MPDL3280A, Stereotactic Body Radiation Therapy - Recurrent Non-Small Cell Lung Carcinoma, Stage IV Non-Small Cell Lung Cancer | Phase 1 | Terminated | Megan Daly, MD | 27 | 2015-12-03 | 2022-08-04 |
| Pembrolizumab and Afatinib in Patients With Non-small Cell Lung Cancer With Resistance to Erlotinib Afatinib Dimaleate, Pembrolizumab - Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer | Phase 1 | Completed | Jonathan Riess | 11 | 2015-09-30 | 2024-10-16 |
| Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors Cisplatin, Docetaxel, Gemcitabine Hydrochloride - Head and Neck Squamous Cell Carcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 1 | Active not recruiting | University of Southern California | 61 | 2015-09-03 | 2026-04-29 |
| Buparlisib, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Advanced Solid Tumors Buparlisib, Cisplatin, Gemcitabine Hydrochloride - Adult Solid Neoplasm, Recurrent Non-Small Cell Lung Carcinoma | Phase 1 | Withdrawn | Roswell Park Cancer Institute | 2015-09-01 | 2023-04-27 | |
| Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma Aldesleukin, Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes, Cyclophosphamide - Advanced Pleural Malignant Mesothelioma, HLA-A*0201 Positive Cells Present | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 11 | 2015-05-22 | 2021-09-13 |
| Azacitidine in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer Azacitidine, Laboratory Biomarker Analysis, Pharmacological Study - Recurrent Non-Small Cell Lung Carcinoma, Stage IV Non-Small Cell Lung Cancer | Phase 1 | Completed | Albert Einstein College of Medicine | 8 | 2015-02-09 | 2020-02-07 |
| Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Breast Cancer, Non-small Cell Lung Cancer, or Prostate Cancer Stereotactic Body Radiation Therapy (SBRT) - Male Breast Carcinoma, Prostate Adenocarcinoma | Phase 1 | Completed | NRG Oncology | 42 | 2014-08-01 | 2026-06-25 |
| Erlotinib Hydrochloride in Treating Non-Small Cell Lung Cancer That is Metastatic or Cannot be Removed by Surgery in Patients With HIV Infection Erlotinib Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study - HIV Infection, Recurrent Non-Small Cell Lung Carcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 48 | 2014-07-01 | 2015-10-06 |
| Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung Cancer Auranofin, Sirolimus, Laboratory Biomarker Analysis - Extensive Stage Small Cell Lung Carcinoma, Lung Adenocarcinoma | Phase 1 / Phase 2 | Completed | Mayo Clinic | 29 | 2014-05-14 | 2025-09-05 |
| Photodynamic Therapy During Surgery in Treating Patients With Non-small Cell Lung Cancer That Can Be Removed by Surgery Temoporfin, Therapeutic Conventional Surgery, Photodynamic Therapy - Recurrent Non-Small Cell Lung Carcinoma, Stage IIA Non-Small Cell Lung Carcinoma | Phase 1 | Completed | Roswell Park Cancer Institute | 8 | 2014-02-21 | 2022-07-22 |
| Recombinant Interleukin-15 in Treating Patients With Advanced Melanoma, Kidney Cancer, Non-small Cell Lung Cancer, or Squamous Cell Head and Neck Cancer Laboratory Biomarker Analysis, Pharmacological Study, Recombinant Human Interleukin-15 - Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Carcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2013-02-15 | 2017-09-15 |
| RO4929097 and Erlotinib Hydrochloride in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer Erlotinib Hydrochloride, Gamma-Secretase Inhibitor RO4929097, Laboratory Biomarker Analysis - Recurrent Non-Small Cell Lung Carcinoma, Stage IV Non-Small Cell Lung Cancer | Phase 1 | Terminated | National Cancer Institute (NCI) | 16 | 2010-08-01 | 2015-09-29 |
| Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2010-05-01 | 2014-12-23 |
| Azacitidine and Entinostat in Treating Patients With Recurrent Advanced Non-Small Cell Lung Cancer Azacitidine 30mg/m2, Entinostat, Azacitidine 40mg/m2 - Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 94 | 2006-08-01 | 2019-05-09 |
Carcinoma, Non-Small-Cell Lung (18) · Breast Neoplasms (3) · Carcinoma, Renal Cell (3) · Melanoma (3) · Pancreatic Neoplasms (3) · Breast Neoplasms, Male (2) · Squamous Cell Carcinoma of Head and Neck (2) · Adenocarcinoma of Lung (1) · Astrocytoma (1) · Brain Neoplasms (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Ependymoma (1) · Gallbladder Neoplasms (1) · Glioblastoma (1)
Bronchial Neoplasms (18) · Carcinoma, Bronchogenic (18) · Lung Diseases (18) · Lung Neoplasms (18) · Neoplasms (18) · Neoplasms by Site (18) · Respiratory Tract Diseases (18) · Respiratory Tract Neoplasms (18) · Thoracic Neoplasms (18) · Neoplasms by Histologic Type (6) · Neoplasms, Glandular and Epithelial (6) · Carcinoma (5) · Urogenital Diseases (5) · Adenocarcinoma (4) · Male Urogenital Diseases (4)
1,2-diaminocyclohexaneplatinum II citrate (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (2) · Azacitidine (2) · Cisplatin (2) · Cyclophosphamide (2) · Docetaxel (2) · Erlotinib Hydrochloride (2) · Gemcitabine (2) · Nivolumab (2) · Platinum (2) · Radiosurgery (2) · 1-phenyl-3,3-dimethyltriazene (1) · 130-nm albumin-bound paclitaxel (1) · Afatinib (1) · Albumin-Bound Paclitaxel (1)
National Cancer Institute (NCI) (5) · Roswell Park Cancer Institute (3) · Mayo Clinic (2) · Albert Einstein College of Medicine (1) · Fred Hutchinson Cancer Center (1) · Jonathan Riess (1) · Jonsson Comprehensive Cancer Center (1) · Megan Daly, MD (1) · NRG Oncology (1) · University of Southern California (1) · University of Washington (1)
United States (17) · Canada (2) · Switzerland (1)
Alex Adjei (1) · Anthony El-Khoueiry (1) · Chukwumere Nwogu (1) · Don Gibbons (1) · Edward Garon (1) · Grace Dy (1) · Jeffrey Miller (1) · John Wrangle (1) · Jonathan Riess (1) · Karen Kelly (1) · Missak Haigentz (1) · Peter Cohen (1) · Rafael Santana-Davila (1) · Roman Perez-Soler (1) · Sebastien Hotte (1)
PMID 22586682, PMID 29203590, PMID 30045932, PMID 33636454, PMID 33885704, PMID 35254001, PMID 41114938
P30CA015704 (2), P30CA093373 (2), N01CM00039 (1), N01CM62202 (1), P30CA006973 (1), P30CA013330 (1), P30CA014089 (1), P30CA015083 (1), P30CA016672 (1), R21CA153000 (1), U01CA062461 (1), U01CA070095 (1), U01CA121947 (1), U01CA132123 (1), U01CA154967 (1)