10 completed, 2 terminated, 1 withdrawn. 8 Phase 1, 2 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Completed 7, Terminated 1 |
| Not applicable | 2 | Terminated 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
Follow Recurrent Childhood Visual Pathway Glioma: new trials by email Literature Review of Recurrent Childhood Visual Pathway Glioma trials Research Report on Recurrent Childhood Visual Pathway Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Laboratory Biomarker Analysis, Pharmacological Study, Pomalidomide - Neurofibromatosis Type 1, Recurrent Childhood Brain Stem Glioma | Phase 1 | Completed | National Cancer Institute (NCI) | 29 | 2015-07-14 | 2022-04-25 |
| 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas 18F-fluoro-dihydroxyphenylalanine, Positron emission tomography (PET), Computed tomography (CT) - Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma | Not applicable | Terminated | Erik Mittra | 2 | 2014-12-01 | 2017-03-20 |
| Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors gallium Ga 68-edotreotide, positron emission tomography, computed tomography - Acoustic Schwannoma, Adult Anaplastic Astrocytoma | Not applicable | Withdrawn | Sue O'Dorisio | 2013-09-01 | 2017-04-28 | |
| Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Lenalidomide, Pharmacological Study - Neurofibromatosis Type 1, Recurrent Childhood Pilocytic Astrocytoma | Phase 2 | Completed | National Cancer Institute (NCI) | 75 | 2012-07-05 | 2025-01-07 |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment pazopanib hydrochloride, pharmacological study - Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2009-06-01 | 2013-09-30 |
| Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor busulfan, melphalan, topotecan hydrochloride - Solid Tumor, Adult Central Nervous System Germ Cell Tumor | Phase 1 | Completed | City of Hope Medical Center | 25 | 2007-02-26 | 2025-03-20 |
| AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Cediranib Maleate - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2006-03-01 | 2016-03-07 |
| Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas irinotecan hydrochloride, oxaliplatin - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2005-03-01 | 2013-06-05 |
| Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Cytology Specimen Collection Procedure - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Completed | Children's Oncology Group | 1258 | 2004-02-16 | 2018-07-16 | |
| Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas alvocidib, pharmacological study - Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Cerebellar Astrocytoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2001-04-01 | 2013-07-02 |
| Irinotecan in Treating Children With Refractory Solid Tumors irinotecan hydrochloride - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 2 | Completed | Children's Oncology Group | 181 | 1999-10-01 | 2013-06-14 |
Optic Nerve Glioma (13) · Astrocytoma (11) · Familial ependymoma (9) · Medulloblastoma (9) · Oligodendroglioma (7) · Choroid Plexus Neoplasms (5) · Burkitt Lymphoma (4) · Dendritic Cell Sarcoma, Interdigitating (4) · Neuroblastoma (4) · Neuroectodermal Tumors, Primitive, Peripheral (4) · Recurrence (4) · Brain Neoplasms (3) · Ependymoma (3) · Osteosarcoma (3) · Rhabdoid Tumor (3)
Cranial Nerve Diseases (13) · Cranial Nerve Neoplasms (13) · Eye Diseases (13) · Neoplasms (13) · Neoplasms by Histologic Type (13) · Neoplasms by Site (13) · Neoplasms, Germ Cell and Embryonal (13) · Neoplasms, Glandular and Epithelial (13) · Neoplasms, Nerve Tissue (13) · Nervous System Diseases (13) · Nervous System Neoplasms (13) · Neuroectodermal Tumors (13) · Optic Nerve Diseases (13) · Optic Nerve Neoplasms (13) · Peripheral Nervous System Neoplasms (13)
2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (2) · Irinotecan (2) · Magnetic Resonance Spectroscopy (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Bone Marrow Transplantation (1) · Bortezomib (1) · Busulfan (1) · Calcium Dobesilate (1) · Dexamethasone (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Lenalidomide (1) · Melphalan (1) · Oxaliplatin (1) · Topotecan (1)
National Cancer Institute (NCI) (8) · Children's Oncology Group (2) · City of Hope Medical Center (1) · Erik Mittra (1) · Sue O'Dorisio (1)
United States (13) · Canada (3) · Australia (2) · New Zealand (2) · Puerto Rico (1) · Switzerland (1)
Anna Pawlowska, MD (1) · Erik Mittra, MD, PhD (1) · James Whitlock (1) · Jason R Fangusaro (1) · Jodi Muscal (1) · Julia Glade-Bender (1) · Katherine E Warren (1) · Lisa Bomgaars (1) · Lisa McGregor (1) · M. Sue O'Dorisio, MD, PhD (1) · Mark Kieran (1) · Najat Daw (1) · Scott Pomeroy (1)
U01CA097452 (5), U10CA098543 (3), P30CA086862 (1), P30CA124435 (1), U01CA081457 (1), U10CA180886 (1), UG1CA189958 (1), UM1CA081457 (1)