14 completed, 3 not yet recruiting, 2 recruiting, 2 unknown. 10 Not applicable, 6 Phase 2, 3 Phase 4, 2 Phase 1, 1 Phase 3.
Follow Recurrent Aphthous Stomatitis: new trials by email Literature Review of Recurrent Aphthous Stomatitis trials Research Report on Recurrent Aphthous Stomatitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sesame Paste for Recurrent Aphthous Stomatitis Sesame paste, Placebo - Recurrent Aphthous Stomatitis | Not applicable | Not yet recruiting | Ayat Gamal-AbdelNaser | 46 | 2026-12-01 | 2026-10-01 |
| Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model Pharmacist-Led Prescribing Optimization and Patient Counselling - Oral Lichen Planus, Recurrent Aphthous Stomatitis | Not applicable | Not yet recruiting | University of Fujairah | 336 | 2026-07-01 | 2026-07-22 |
| The Preventive and Therapeutic Effects of Spirulina Preparations on Ulcers of Oral Mucosa Spirulina Tablets, Placebo Tablets - Recurrent Aphthous Stomatitis, Mouth Ulcer | Not applicable | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 40 | 2026-06-01 | 2026-07-23 |
| Effect of Zinc Oxide Ointment on Recurrent Aphthous Stomatitis zinc oxide, Placabo - Recurrent Aphthous Stomatitis | Phase 4 | Completed | Faculty of Dental Medicine for Girls | 100 | 2025-06-30 | 2026-05-04 |
| Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis 35% Topical Bromelain in Orabase, 50% Topical Bromelain in Orabase, 0.1% Topical Triamcinolone Acetonide in Orabase - Recurrent Aphthous Stomatitis | Phase 2 | Not yet recruiting | Cairo University | 63 | 2025-06-15 | 2025-05-28 |
| Salivary E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 Levels in Recurrent Aphthous Stomatitis ELISA - Recurrent Aphthous Stomatitis, Aphthous Ulcer | Recruiting | Selin Yeşiltepe | 102 | 2025-04-10 | 2025-08-26 | |
| The Efficacy of Erythropoietin Oral Gel Versus Erythropoietin Mouthwash in the Management of Recurrent Aphthous Stomatitis Epoetin 4000, Placebo - Recurrent Aphthous Stomatitis | Phase 4 | Completed | Future University in Egypt | 60 | 2024-07-01 | 2025-08-26 |
| A Study on Sumac Mouth Rinse for Treating Recurrent Aphthous Stomatitis Sumac mouth rinse, Tantum Verde mouth rinse - Recurrent Aphthous Stomatitis | Not applicable | Completed | Ain Shams University | 38 | 2023-12-20 | 2026-05-08 |
| α-Mangostin Hydrogel Film With Chitosan Alginate Base for Recurrent Aphthous Stomatitis (RAS) α-Mangostin Hydrogel Film With Chitosan Alginate Base, Placebo - Recurrent Aphthous Stomatitis | Phase 2 | Unknown | Universitas Padjadjaran | 48 | 2023-12-04 | 2023-11-15 |
| Effectiveness of Recurrent Aphthous Stomatitis Mouthwash System for the Treatment of Oral Ulcers Mouthwash Product, Control - Recurrent Aphthous Ulcer, Recurrent Aphthous Stomatitis | Not applicable | Completed | G. d'Annunzio University | 60 | 2023-11-28 | 2025-08-13 |
| Topical Hyaluronic Acid and Recurrent Aphthous Stomatitis. Hyaluronic acid in the form of hyaluronan sodium 25 mg/100 ml as a mouthwash - Recurrent Aphthous Stomatitis | Phase 3 | Completed | Cairo University | 34 | 2019-11-01 | 2020-02-11 |
| Apremilast for RAS Apremilast 30mg - Recurrent Aphthous Stomatitis | Phase 4 | Completed | Mayo Clinic | 15 | 2018-10-12 | 2022-07-14 |
| Curcumin and Nanocurcumin in Oral Aphthous Ulcer Gel - Recurrent Aphthous Ulcer, Recurrent Aphthous Stomatitis | Not applicable | Completed | Shahid Beheshti University of Medical Sciences | 48 | 2018-07-15 | 2020-05-13 |
| Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Huanglian-Jiedu Decoction - Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis | Phase 1 / Phase 2 | Unknown | China Academy of Chinese Medical Sciences | 240 | 2018-04-04 | 2018-04-10 |
| Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis vitamin B12 treatment - Recurrent Aphthous Stomatitis | Not applicable | Terminated | Meir Medical Center | 8 | 2012-06-01 | 2014-11-19 |
| Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases NAVS Naphthalan, 0.05% Betamethasone dipropionate - Oral Lichen Planus, Recurrent Aphthous Stomatitis | Phase 2 | Completed | Ivan Alajbeg | 57 | 2010-12-01 | 2016-09-30 |
| Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae chamomilla tincture mouthwash, placebo mouthwash - Recurrent Aphthous Stomatitis | Phase 1 | Completed | Mashhad University of Medical Sciences | 30 | 2010-04-01 | 2011-08-02 |
| Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Yunnan Baiyao toothpaste, Placebo toothpaste - Recurrent Aphthous Stomatitis | Phase 2 | Completed | Peking University | 227 | 2010-03-01 | 2012-07-30 |
| Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis sodium lauryl sulfate - Recurrent Aphthous Stomatitis | Not applicable | Completed | Yonsei University | 90 | 2010-01-01 | 2011-12-29 |
| Efficacy of 5% Chitosan Nanoparticle Paste in the Treatment of Recurrent Aphthous Stomatitis Triamcinolone Acetonide 0.1% Oral Paste, 5 wt.% Chitosan Nanoparticle Paste - Recurrent Aphthous Stomatitis, Oral Ulcers | Phase 2 | Completed | Kerman University of Medical Sciences | 30 | 2009-04-21 | 2026-07-14 |
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Stomatitis, Aphthous (22) · Oral Ulcer (3) · Lichen Planus, Oral (2) · Pain (2) · Burning Mouth Syndrome (1) · Candidiasis, Oral (1) · Herpes Labialis (1) · Herpesviridae Infections (1) · Patient Compliance (1) · Ulcer (1)
Mouth Diseases (22) · Stomatitis (22) · Stomatognathic Diseases (22) · Pathological Conditions, Signs and Symptoms (3) · Skin Diseases (3) · Skin and Connective Tissue Diseases (3) · DNA Virus Infections (2) · Infections (2) · Lichen Planus (2) · Lichenoid Eruptions (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Skin Diseases, Papulosquamous (2) · Virus Diseases (2) · Bacterial Infections and Mycoses (1)
Ointments (2) · Triamcinolone Acetonide (2) · Vitamin B 12 (2) · Bromelains (1) · Gels (1) · Gramicidin, Neomycin Sulfate, Nystatin, Triamcinolone Acetonide Drug Combination (1) · Hyaluronic Acid (1) · Orabase (1) · Pentoxifylline (1) · Sodium Dodecyl Sulfate (1) · Zinc Oxide (1) · apremilast (1) · betamethasone-17,21-dipropionate (1) · huanglian-jie-du decoction (1)
Cairo University (2) · Ain Shams University (1) · Ayat Gamal-AbdelNaser (1) · China Academy of Chinese Medical Sciences (1) · Faculty of Dental Medicine for Girls (1) · Future University in Egypt (1) · G. d'Annunzio University (1) · Ivan Alajbeg (1) · Kerman University of Medical Sciences (1) · Manchester University NHS Foundation Trust (1) · Mashhad University of Medical Sciences (1) · Mayo Clinic (1) · Meir Medical Center (1) · Peking University (1) · Selin Yeşiltepe (1)
Egypt (4) · China (2) · Iran (2) · Israel (2) · Croatia (1) · Indonesia (1) · Italy (1) · Turkey (Türkiye) (1) · United Kingdom (1) · United States (1)
Alison J Bruce (1) · Ilia Volkov, MD (1) · Indah Suasani Wahyuni, drg. (1) · Ivan Alajbeg, PhD (1) · Jeong-Seung Kwon (1) · Martin H Thornhill, MBBS, BDS (1) · Naglaa M. El-Wakeel, PhD (1) · Nasma Pulikkalakath (1) · Prof. Antonio Scarano Antonio Scarano, MD DDS (1) · Ramam Sripada (1) · Tamer Hassan (1) · Xu Huang, PhD (1) · Yan Press, MD (1)
PMID 17438178, PMID 19124628, PMID 33831097, PMID 38434698, PMID 41851196