215 completed, 48 unknown, 46 recruiting, 28 not yet recruiting. 292 Not applicable, 7 Phase 2, 6 Phase 1, 4 Phase 3, 1 Phase 4.
Follow Psychological Distress: new trials by email Literature Review of Psychological Distress trials Research Report on Psychological Distress
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Community-based, Peer-led Counseling Service: A Hybrid Type 3 Effectiveness-implementation Study Psychological Distress, Stress Psychological | Not yet recruiting | St.Gallen University of Applied Sciences | 65 | 2026-12-01 | 2026-10-21 | |
| ACT-Based Counseling to Improve Psychological Flexibility in Mothers of Infants Hospitalized in the NICU ACT-Based Online Psychoeducational Workshop, ACT-Based Chatbot Counseling - Psychological Flexibility, Psychological Distress | Not applicable | Not yet recruiting | Meserret Aslan | 135 | 2026-11-01 | 2026-09-23 |
| Interactive Nature-Based Virtual Reality to Reduce Anxiety, Low Mood, and Feelings of Helplessness in Hospitalized Older Adults With Chronic Illness (Zenctuary VR+) Interactive nature-based virtual reality intervention, Passive nature-based virtual reality exposure - Psychological Distress, Chronic Disease | Not applicable | Not yet recruiting | Moholy-Nagy University of Art and Design | 100 | 2026-11-01 | 2026-07-21 |
| Group Psychological Intervention to Reduce Distress Among Nursing Undergraduates Intervention program for psychological distress among nursing undergraduates, Routine mental health education - Psychological Distress | Not applicable | Not yet recruiting | Liu Jingying | 84 | 2026-11-01 | 2026-11-03 |
| MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial PEX010 25 mg psilocybin, PEX010 5 mg psilocybin, Standard Psilocybin-Assisted Therapy - Advanced Cancer, Demoralization | Phase 2 | Not yet recruiting | University of Calgary | 60 | 2026-10-30 | 2026-09-02 |
| Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms Non-deceptive placebo (NDP) - Depression - Major Depressive Disorder, Psychological Distress | Not applicable | Not yet recruiting | Miami University | 330 | 2026-10-25 | 2026-10-22 |
| Two Sessions of Coach-Delivered Core Transformation for Distress and Well-Being Core Transformation Process - Psychological Distress, Psychological Well-being | Not applicable | Not yet recruiting | Andreas NLP (Legal Entity - Real People Press) | 480 | 2026-10-20 | 2026-10-21 |
| EMI for Reducing Psychological Distress in Young Adults With Multiple ACEs: A RCT Study EMI - Psychological Distress, Adverse Childhood Experience | Not applicable | Not yet recruiting | Peking University | 100 | 2026-10-19 | 2026-10-21 |
| EMI for Reducing Psychological Distress in Young Adults With Multiple ACEs: A Feasibility Study EMI - Psychological Distress, Adverse Childhood Experience | Not applicable | Not yet recruiting | Peking University | 20 | 2026-10-17 | 2026-10-16 |
| Healing Hearts: A Mindfulness App for Parents Navigating Divorce or Separation Healing Hearts, electronic New Beginnings Program, Curated internet resources - Mental Health, Parenting / Maternal Behavior | Not applicable | Recruiting | University of Connecticut | 96 | 2026-10-05 | 2026-10-13 |
| Ecological Momentary Intervention (E-Breathing) to Reduce Psychological Distress in Adolescents Slow-paced breathing via ecological momentary intervention, Ecological momentary assessments - Psychological Distress, Depressed Mood | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 100 | 2026-10-01 | 2026-07-21 |
| The Validation of ICBT Clinical Trial: Disease Stress Adjustment in Breast Cancer Patients Internet-Based Cognitive Behavioral Therapy Program for Breast Cancer Survivors, Treatment as Usual (TAU) - Breast Cancer, Psychological Distress | Not applicable | Not yet recruiting | National Health Research Institutes, Taiwan | 100 | 2026-10-01 | 2026-09-23 |
| Testing an Adaptive Intervention for Peer-Supported Mobile Health for Primary Care Veterans With Psychological Distress Self Managed mHealth, 1 session of peer mHealth, 4 sessions Peer mHealth - Psychological Distress | Not applicable | Recruiting | VA Office of Research and Development | 384 | 2026-09-27 | 2026-10-02 |
| Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients ZenctuaryVR+ Interactive Virtual Reality - Palliative Care, Refractory Pain | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 20 | 2026-09-01 | 2026-04-22 |
| Psychological Support and Psycho-Emotional Trajectories in Cancer Genetics. Patients undergoing their first cancer genetic testing consultation who choose to utilise the clinical psychological support offered by the unit, Patients undergoing their first cancer genetic testing consultation who choose to follow the care pathway without utilising the systematically offered clinical psychological support. - Psychological Distress, Genetic Testing | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 220 | 2026-09-01 | 2026-07-10 | |
| Feasibility of a Real-world, Financial Psycho-oncology Intervention to Address Cancer-related Financial Distress Financial psycho-oncology intervention - Cancer, Financial Hardship | Not applicable | Recruiting | University of Alabama at Birmingham | 20 | 2026-09-01 | 2026-10-05 |
| Support and Healing Intervention for Adolescents With a Parent Diagnosed With Cancer (SHINE) SHINE Psychosocial Intervention, Usual Supportive Care - Cancer, Psychological Distress | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 80 | 2026-09-01 | 2026-08-07 |
| PICS-p Longitudinal Cohort Study Physical Functional Impairment, Cognitive Impairment | Not yet recruiting | Children's Hospital of Fudan University | 200 | 2026-09-01 | 2026-10-15 | |
| Development of a Multilevel HIV Prevention Intervention for the Emergency Department mSYNC - HIV, Drug Use | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 100 | 2026-09-01 | 2026-07-09 |
| Effect of Mandala Art Therapy on Childbirth Fear and Anxiety in Expectant Fathers Mandala Art Therapy - Paternal Childbirth Fear, State Anxiety | Not applicable | Not yet recruiting | Inonu University | 148 | 2026-09-01 | 2026-07-20 |
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