27 completed, 9 recruiting, 4 unknown, 4 withdrawn. 32 Not applicable, 9 Phase 2, 5 Phase 1, 4 Phase 3, 1 Phase 4.
Follow Histamine: new trials by email Literature Review of Histamine trials Research Report on Histamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pain Sensitivity and Pruritus of Peripheral Nerves Mepyramine cream, Histamine Dihydrochloride (HDC), Cowhage (Mucuna Pruriens) - ITCH | Not applicable | Active not recruiting | Aalborg University | 20 | 2026-10-15 | 2026-11-09 |
| Marsili Syndrome as a Gateway to Novel Analgesic Targets Histamine, Cowhage (Mucuna Pruriens), Capsaicin 8% Patch - Marsili Syndrome | Not applicable | Active not recruiting | Aalborg University | 4 | 2026-08-01 | 2026-11-09 |
| The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch Delgocitinib cream, lidocaine cream, Lidocaine+Delgocitinib - Itchiness | Not applicable | Recruiting | Aalborg University | 30 | 2026-05-01 | 2026-11-09 |
| A New Model to Induce Itch and Inflammation Cowhage (Mucuna Pruriens), Histamine, Heat - Itching | Not applicable | Completed | Aalborg University | 28 | 2026-02-15 | 2026-11-09 |
| Mechanisms Underlying the Nocibo Effect of Contagious Itch. in Both Histaminergic and Nonhistaminergic Itch Histamine, Cowhage (Mucuna Pruriens), Placebo - ITCH | Not applicable | Recruiting | Aalborg University | 30 | 2025-12-01 | 2026-11-09 |
| Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch Histamine, Cowhage - ITCH | Not applicable | Recruiting | Aalborg University | 30 | 2025-11-03 | 2025-12-04 |
| Topographical Distribution of Itch and Pain Receptors Histamine, Cowhage, Capsaicin 8% Patch - Pain, Itch | Not applicable | Recruiting | Aalborg University | 30 | 2025-09-17 | 2026-11-06 |
| Role of Interleukin-13 Pathways on Pain and Itch Sensitivity ( IL-13 ) histamine dihydrochloride, Cowhage - Itching | Not applicable | Active not recruiting | Aalborg University | 26 | 2025-05-15 | 2026-11-06 |
| Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge - Drug Allergy, Cephalosporin Allergy | Phase 2 | Recruiting | Massachusetts General Hospital | 300 | 2025-05-05 | 2026-11-12 |
| Role of Interleukin-13 Pathways on Pain and Itch Sensitivity Histamine, Cowhage, bovine adrenal medulla (BAM8-22) - Itch | Not applicable | Recruiting | Aalborg University | 20 | 2025-01-06 | 2026-11-09 |
| Itch Sensation Induced by Multiple Applications of Pruritogens (Temporal Summation) Histamine, Cowhage - Histamine, Cowhage | Not applicable | Completed | Aalborg University | 26 | 2024-11-01 | 2026-11-06 |
| The Effects of Performing a Motor Imagery Task on Cortical Excitability During Acute Experimental Muscle Pain and Acute Itch Hypertonic Saline, Histamine, Cowhage - Itch, Pain | Not applicable | Recruiting | Aalborg University | 30 | 2024-10-01 | 2026-11-09 |
| Effect of Ketamine, Amitriptyline and Their Combination on Itch Ketamine 0.5%, Amitriptyline, ketamine + amitriptyline - Itch | Not applicable | Completed | Aalborg University | 30 | 2024-08-20 | 2025-01-30 |
| Investigation of Corticospinal Excitability Aspects of Itch and Pain Hypertonic Saline, Histamine, Cowhage - Itch, Pain | Not applicable | Completed | Aalborg University | 30 | 2024-07-01 | 2024-11-22 |
| Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals Histamine, Cowhage - Histamine, Cowhage | Not applicable | Recruiting | Aalborg University | 46 | 2024-04-27 | 2026-11-06 |
| Histamine Dihydrochloride and Interleukin-2 in Primary Resectable Pancreatic Cancer Histamine Dihydrochloride (HDC), Interleukin-2 (IL-2) - Pancreatic Cancer, Surgery | Phase 2 | Not yet recruiting | Sahlgrenska University Hospital | 50 | 2024-04-01 | 2023-11-22 |
| Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation) Cowhage, Histamine - Histamine, Cowhage | Not applicable | Completed | Aalborg University | 24 | 2024-04-01 | 2026-11-09 |
| Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception Histamine, Cowhage - Histamine, Cowhage | Not applicable | Completed | Aalborg University | 30 | 2023-12-15 | 2025-06-04 |
| Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity Histamine, Cowhage - Histamine, Cowhage | Not applicable | Completed | Aalborg University | 30 | 2023-12-15 | 2026-11-09 |
| Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity Histamine, Cowhage - Histamine, Cowhage | Not applicable | Recruiting | Aalborg University | 30 | 2023-11-01 | 2026-11-06 |
Showing 20 of 49. Sign in to see all of them.
Pruritus (17) · Hypersensitivity (6) · Pain (5) · Multiple Sclerosis (3) · Rhinitis, Allergic (3) · Leukemia (2) · Neoplasm Metastasis (2) · Sleep Deprivation (2) · Anaphylaxis (1) · Asthma (1) · Carcinoma, Renal Cell (1) · Drug Hypersensitivity (1) · Dust Mite Allergy (1) · Fatigue (1) · Inflammation (1)
Aalborg University (26) · Universitaire Ziekenhuizen KU Leuven (3) · Apimeds, Inc. (2) · Maxim Pharmaceuticals (2) · Amphastar Pharmaceuticals, Inc. (1) · Anergis (1) · Cuneyt M. Alper (1) · Cytovia, Inc. (1) · Dynavax Technologies Corporation (1) · GlaxoSmithKline (1) · Groupe Francophone des Myelodysplasies (1) · Guangzhou Institute of Respiratory Disease (1) · KeraNetics, LLC (1) · Massachusetts General Hospital (1) · Sahlgrenska University Hospital (1)
Denmark (27) · United States (9) · United Kingdom (4) · Belgium (3) · Canada (3) · Sweden (3) · France (2) · Germany (2) · Australia (1) · China (1) · Estonia (1) · Finland (1) · Israel (1) · Netherlands (1) · New Zealand (1)
Silvia Lo Vecchio (2) · Andreas Muth (1) · Barbara Berryhill (1) · Christopher M. H. Kim, M.D. (1) · Cris Constantinescu, MD PhD (1) · Cuneyt M Alper, MD (1) · Daniele Riccio, MSc (1) · David A Khan, MD (1) · Eduardo Martins, MD, DPhil (1) · Francois Spertini, MD (1) · Jinping Zheng, professor (1) · John A. Glaspy, MD, MPH (1) · Jonathan P Wilson, DO (1)
PMID 20412135, PMID 21429214, PMID 21546500, PMID 23725004, PMID 26863635, PMID 27347089, PMID 28235771, PMID 28529313, PMID 28721449, PMID 30315349, PMID 34367728, PMID 34956230
P50DC007667 (1), U01AI184071 (1)