8 completed, 5 recruiting, 2 terminated, 2 unknown. 5 Phase 2, 2 Early Phase 1, 2 Phase 1, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Unknown 2, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Early Phase 1 | 2 | Completed 2 |
| Phase 1 | 2 | Recruiting 1, Terminated 1 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Not yet recruiting 1 |
Follow Progressive Multifocal Leukoencephalopathy: new trials by email Literature Review of Progressive Multifocal Leukoencephalopathy trials Research Report on Progressive Multifocal Leukoencephalopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study Brincidofovir - Progressive Multifocal Leukoencephalopathy | Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 24 | 2026-06-05 | 2026-07-22 |
| Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia Ozanimod - Multiple Sclerosis, Progressive Multifocal Leukoencephalopathy | Recruiting | Bristol-Myers Squibb | 15 | 2026-06-04 | 2026-07-29 | |
| Pembrolizumab in Progressive Multifocal Leukoencephalopathy (PML) in Immunocompromised Patients Without HIV Infection Pembrolizumab, 25 mg/ml solution for intravenous (IV) injection - Progressive Multifocal Leukoencephalopathy | Phase 2 / Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 33 | 2024-04-01 | 2024-02-26 |
| Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy 89 Zr-Df-crefmirlimab - Progressive Multifocal Leukoencephalopathy, Multiple Sclerosis | Phase 1 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 15 | 2023-10-19 | 2026-06-05 |
| Observational Cohort Study of Chronic Viral Infection in the Central Nervous System Immune Checkpoint Inhibitors - Progressive Multifocal Leukoencephalopathy, Immune Checkpoint Inhibitors | Recruiting | Peking Union Medical College Hospital | 66 | 2023-02-20 | 2026-04-06 | |
| A Phase 2 Study Evaluating JCPyV-specific T Cell Therapy for PML CE-VST01-JC - Progressive Multifocal Leukoencephalopathy | Phase 2 | Unknown | Cellevolve Bio Inc | 60 | 2023-02-01 | 2022-09-16 |
| NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy NT-I7 - Progressive Multifocal Leukoencephalopathy | Early Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 12 | 2021-05-05 | 2025-11-18 |
| Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy Collection of blood and urine, Spinal tap, Brain MRI - Progressive Multifocal Leukoencephalopathy | Not applicable | Completed | University Hospital, Toulouse | 22 | 2021-02-23 | 2025-12-31 |
| Treatment of PD-1 Inhibitor in AIDS-associated PML Pembrolizumab - Progressive Multifocal Leukoencephalopathy, AIDS | Phase 2 | Unknown | First Affiliated Hospital of Zhejiang University | 10 | 2019-08-20 | 2019-09-20 |
| Tysabri Observational Cohort Study - Multiple Sclerosis (MS) Registries Tysabri - Progressive Multifocal Leukoencephalopathy | Completed | Biogen | 80327 | 2017-06-01 | 2024-03-19 | |
| Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells PyVST - Progressive Multifocal Leukoencephalopathy | Early Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 60 | 2016-03-28 | 2026-07-17 |
| Natural History Study of Progressive Multifocal Leukoencephalopathy (PML) Progressive Multifocal Leukoencephalopathy | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 700 | 2012-11-08 | 2026-10-26 | |
| JC Virus Reactivation in Multiple Sclerosis Progressive Multifocal Leukoencephalopathy, Multiple Sclerosis | Completed | Beth Israel Deaconess Medical Center | 50 | 2010-10-01 | 2016-01-29 | |
| Genetic Evaluation of Natalizumab-Treated Patients With Progressive Multifocal Leukoencephalopathy Progressive Multifocal Leukoencephalopathy | Terminated | Biogen | 24 | 2010-10-01 | 2015-01-19 | |
| Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) mefloquine - Progressive Multifocal Leukoencephalopathy | Phase 1 / Phase 2 | Terminated | Biogen | 37 | 2009-01-01 | 2014-07-31 |
| Retrospective Study of the Survival of Patients Suffering From Hiv-related Progressive Multifocal Leukoencephalopathy Progressive Multifocal Leukoencephalopathy | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 34 | 2006-01-01 | 2016-09-09 | |
| Role of Inflammation in Progressive Multifocal Leukoencephalopathy (PML) Progressive Multifocal Leukoencephalopathy | Completed | Beth Israel Deaconess Medical Center | 126 | 2004-06-01 | 2023-08-14 | |
| Observational Study on Characteristics and Survival Correlates of Progressive Multifocal Leukoencephalopathy (PML) in Italy Progressive Multifocal Leukoencephalopathy, PML | Completed | Scientific Institute San Raffaele | 456 | 1987-01-01 | 2024-09-19 |
Leukoencephalopathy, Progressive Multifocal (18) · Multiple Sclerosis (4) · Acquired Immunodeficiency Syndrome (2) · Central Nervous System Diseases (1) · Encephalitis (1) · Immune Reconstitution Inflammatory Syndrome (1)
Brain Diseases (18) · Central Nervous System Infections (18) · Central Nervous System Viral Diseases (18) · DNA Virus Infections (18) · Demyelinating Diseases (18) · Encephalitis, Viral (18) · Infections (18) · Infectious Encephalitis (18) · Leukoencephalopathies (18) · Nervous System Diseases (18) · Neuroinflammatory Diseases (18) · Polyomavirus Infections (18) · Slow Virus Diseases (18) · Virus Diseases (18) · Central Nervous System Diseases (17)
Immune Checkpoint Inhibitors (2) · pembrolizumab (2) · Injections (1) · Mefloquine (1) · Natalizumab (1) · Solutions (1) · Spinal Puncture (1) · Urination (1) · brincidofovir (1) · efineptakin alfa (1) · ozanimod (1)
National Institute of Neurological Disorders and Stroke (NINDS) (5) · Biogen (3) · Beth Israel Deaconess Medical Center (2) · Assistance Publique - Hôpitaux de Paris (1) · Bristol-Myers Squibb (1) · Cellevolve Bio Inc (1) · First Affiliated Hospital of Zhejiang University (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Peking Union Medical College Hospital (1) · Scientific Institute San Raffaele (1) · University Hospital, Toulouse (1)
United States (11) · China (2) · France (2) · Germany (2) · Italy (2) · Brazil (1) · Spain (1)
Irene CM Cortese, M.D. (4) · Biao Zhu, PhD (1) · Chen S Tan, MD (1) · Daniel S Reich, M.D. (1) · Igor J Koralnik, MD (1) · Paola Cinque, MD, PhD (1)
PMID 23733308, PMID 24687904, PMID 34302788
2023 (1)