9 completed, 6 terminated, 3 withdrawn, 2 recruiting. 10 Phase 2, 6 Phase 3, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 3, Withdrawn 3, Terminated 2, Recruiting 1, Suspended 1 |
| Phase 3 | 6 | Completed 3, Terminated 2, Recruiting 1 |
| Phase 1 | 5 | Completed 4, Suspended 1 |
Follow brincidofovir: new trials by email Literature Review of brincidofovir trials Research Report on brincidofovir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study Brincidofovir - Progressive Multifocal Leukoencephalopathy | Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 24 | 2026-06-05 | 2026-07-22 |
| A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT cidofovir, Brincidofovir - Adenovirus Infections | Phase 3 | Recruiting | SymBio Pharmaceuticals | 180 | 2026-03-17 | 2026-10-19 |
| A Phase 1b/2 Study of Intravenous Brincidofovir in Patients With Relapsed or Refractory Lymphoma and Relapsed or Refractory Extranodal Natural Killer/T-cell Lymphoma Brincidofovir - Relapsed or Refractory Lymphoma Including ENKL | Phase 1 / Phase 2 | Suspended | SymBio Pharmaceuticals | 43 | 2025-06-09 | 2026-02-05 |
| Study Evaluating the Bioequivalence of Brincidofovir Form H and Form II Tablets in Healthy Adults Brincidofovir - Smallpox | Phase 1 | Completed | Emergent BioSolutions | 44 | 2023-05-30 | 2025-01-15 |
| Study to Confirm of the Safety and Tolerability of Brincidofovir in Subjects With BK Virus Infection (Viremia) After Kidney Transplantation Brincidofovir - BK Virus Infection, Nephropathy | Phase 2 | Terminated | SymBio Pharmaceuticals | 1 | 2022-10-14 | 2024-12-04 |
| Open Label Study of IV Brincidofovir in Adult Transplant Recipients With Adenovirus Viremia Brincidofovir, Standard of Care - Adenovirus | Phase 2 | Withdrawn | Jazz Pharmaceuticals | 2018-12-15 | 2021-07-21 | |
| The AdAPT Trial; Adenovirus After Allogeneic Pediatric Transplantation Standard of Care, Brincidofovir - Adenovirus | Phase 2 | Terminated | Jazz Pharmaceuticals | 29 | 2017-12-22 | 2021-01-25 |
| A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus Disease Brincidofovir, Valganciclovir - Cytomegalovirus Disease | Phase 3 | Terminated | Jazz Pharmaceuticals | 5 | 2015-09-01 | 2021-07-16 |
| A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus Brincidofovir, Valganciclovir - Cytomegalovirus Disease, Kidney Transplant Infection | Phase 3 | Terminated | Jazz Pharmaceuticals | 6 | 2015-09-01 | 2021-07-16 |
| A Multicenter Study to Obtain Retrospective Data for Subjects Previously Diagnosed With Adenovirus Infection to Serve as Matched Historical Controls for Study CMX001-304 Brincidofovir - Adenovirus | Terminated | Jazz Pharmaceuticals | 100 | 2015-02-01 | 2017-01-09 | |
| An Open-Label, Multicenter Study of the Safety and Anti Viral Activity of Brincidofovir (BCV, CMX001) for Ebola Virus Disease CMX001 - Ebola Virus | Phase 2 | Withdrawn | Jazz Pharmaceuticals | 2014-10-01 | 2015-02-02 | |
| An Open-Label Study , Safety and Tolerability of Brincidofovir for Post Exposure Prophylaxis of Ebola Brincidofovir - Ebola Virus Disease | Phase 2 | Withdrawn | Jazz Pharmaceuticals | 2014-10-01 | 2020-02-26 | |
| Study to Assess the Safety and Efficacy of Brincidofovir in Treatment of Early Versus Late Adenovirus Infection Brincidofovir - Adenovirus Infection | Phase 3 | Completed | Jazz Pharmaceuticals | 201 | 2014-03-01 | 2021-08-13 |
| The Chimerix CMX001 Registry CMX001 - Outcomes, Survival Rates | Terminated | Jazz Pharmaceuticals | 550 | 2014-01-01 | 2019-05-17 | |
| A Study of the Safety and Efficacy of CMX001 for the Prevention of CMV Infection in CMV-seropositive HCT Recipients Brincidofovir, Placebo - CMV | Phase 3 | Completed | Jazz Pharmaceuticals | 452 | 2013-08-01 | 2021-07-21 |
| Safety and Pharmacokinetics of CMX001 in Impaired Hepatic Function and Healthy Subjects CMX001 - Hepatic Impairment | Phase 1 | Completed | Jazz Pharmaceuticals | 25 | 2011-02-01 | 2022-05-26 |
| Study to Assess Brincidofovir Treatment of Serious Diseases or Conditions Caused by Double-stranded DNA Viruses Brincidofovir - Double-stranded DNA Virus | Phase 3 | Completed | Jazz Pharmaceuticals | 210 | 2010-12-01 | 2021-08-12 |
| Phase 2 Study to Evaluate Brincidofovir for the Prevention of Adenovirus Disease Brincidofovir, Placebo - Adenovirus Disease | Phase 2 | Completed | Jazz Pharmaceuticals | 52 | 2010-11-01 | 2021-07-21 |
| CMX001 in Post-transplant Patients With BK Virus Viruria Placebo, Brincidofovir - Viruria | Phase 1 / Phase 2 | Completed | Jazz Pharmaceuticals | 29 | 2009-11-01 | 2021-08-16 |
| Study of CMX001 to Prevent/Control Cytomegalovirus Infection in R+ Hematopoietic Stem Cell Transplant Recipients Brincidofovir, Placebo - Cytomegalovirus Infection | Phase 2 | Completed | Jazz Pharmaceuticals | 239 | 2009-10-01 | 2021-07-16 |
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Adenoviridae Infections (7) · Cytomegalovirus Infections (3) · Smallpox (2) · Epstein-Barr Virus Infections (1) · Hemorrhagic Fever, Ebola (1) · Herpes Simplex (1) · Immunoblastic Lymphadenopathy (1) · Kidney Diseases (1) · Leukemia-Lymphoma, Adult T-Cell (1) · Leukoencephalopathy, Progressive Multifocal (1) · Lymphoma (1) · Lymphoma, Large B-Cell, Diffuse (1) · Lymphoma, Large-Cell, Anaplastic (1) · Lymphoma, T-Cell (1) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (1)
Jazz Pharmaceuticals (17) · SymBio Pharmaceuticals (3) · Emergent BioSolutions (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1)
United States (18) · Belgium (3) · Canada (3) · Italy (3) · Spain (3) · France (2) · Germany (2) · Japan (2) · Netherlands (2) · United Kingdom (2) · Austria (1) · China (1) · Denmark (1) · Ireland (1) · Poland (1)
Dave Cassie, MSc (1) · Evin H Sides, III, MD (1) · Irene CM Cortese, M.D. (1) · Minori Rosales (1)
PMID 27851688, PMID 24066743, PMID 28063938, PMID 30292744, PMID 39382091, PMID 40828617