8 completed, 3 recruiting, 1 terminated, 1 unknown. 4 Not applicable, 2 Phase 2, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 3, Unknown 1 |
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 1, Withdrawn 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Immune Reconstitution Inflammatory Syndrome: new trials by email Literature Review of Immune Reconstitution Inflammatory Syndrome trials Research Report on Immune Reconstitution Inflammatory Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Same-day Versus Rapid ART Initiation in HIV-positive Individuals Presenting With Symptoms of Tuberculosis ART first- Therapeutic use trial, TB results first- Therapeutic use trial - Human Immunodeficiency Virus (HIV) Infection | Not applicable | Completed | University Hospital, Basel, Switzerland | 610 | 2022-10-19 | 2025-04-04 |
| Paradoxical Tuberculosis Reactions in Patients Without HIV Infection Tuberculosis | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 140 | 2019-12-20 | 2026-10-19 | |
| Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controlled-trial. Valganciclovir, Antiretroviral Combinations - Kaposi Sarcoma, Human Immunodeficiency Virus | Phase 2 | Completed | National Institute of Cancerología | 40 | 2015-10-01 | 2022-01-27 |
| PET Imaging and Lymph Node Assessment of IRIS in People With AIDS Immune Reconstitution Inflammatory Syndrome | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 300 | 2014-05-30 | 2026-10-08 | |
| Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial Dexamethasone, Atorvastatin, Naproxen - Immune Reconstitution Inflammatory Syndrome, Immune Reconstitution Syndrome | Phase 2 / Phase 3 | Withdrawn | University of Minnesota | 2014-01-01 | 2013-11-25 | |
| Hepatosplenic CANdidiasis : PETscan and Immune Response Analysis 18F-FDG PET Scan - Invasive Fungal Disease, Chronic Disseminated Candidiasis | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 100 | 2013-11-19 | 2025-09-08 |
| Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone Prednisone, Placebo - Immune Reconstitution Inflammatory Syndrome, HIV | Phase 3 | Completed | University of Cape Town | 240 | 2013-08-30 | 2018-01-19 |
| Pediatric Urgent Start of Highly Active Antiretroviral Treatment (HAART) Urgent ART, Early ART - Human Immunodeficiency Virus, Immune Reconstitution Inflammatory Syndrome | Not applicable | Completed | University of Washington | 183 | 2013-03-01 | 2018-05-14 |
| Natural History Study of Progressive Multifocal Leukoencephalopathy (PML) Progressive Multifocal Leukoencephalopathy | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 700 | 2012-11-08 | 2026-08-31 | |
| Prediction and Pathogenesis of the Immune Reconstitution Inflammatory Syndrome Immune Reconstitution Inflammatory Syndrome, Opportunistic Infections | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 107 | 2012-01-01 | 2015-01-14 | |
| Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) Methylprednisolone, Prednisolone - Immune Reconstitution Inflammatory Syndrome, Leukoencephalopathy, Progressive Multifocal | Phase 4 | Terminated | Biogen | 3 | 2010-09-01 | 2014-09-05 |
| Maraviroc (CCR5) Antagonism to Decrease the Incidence of the Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients maraviroc, Placebo - Immune Reconstitution Inflammatory Syndrome, HIV | Not applicable | Unknown | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 276 | 2009-12-01 | 2012-11-27 |
| Do CCR5 Antagonists Improve the Overall Survival of Patients With AIDS-related Progressive Multifocal Leucoencephalopathy? Measure of overall survival - AIDS, Progressive Multifocal Leucoencephalopathy (PML) | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 34 | 2008-01-01 | 2019-05-31 | |
| Immune Reconstitution Syndrome in HIV-Infected Patients Taking Antiretroviral Therapy Immune Reconstitution Inflammatory Syndrome | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 525 | 2006-02-01 | 2019-10-07 |
Acquired Immunodeficiency Syndrome (6) · Tuberculosis (4) · Leukoencephalopathy, Progressive Multifocal (3) · Opportunistic Infections (2) · Encephalitis (1) · Genetic Predisposition to Disease (1) · HIV Infections (1) · Hematologic Neoplasms (1) · Infections (1) · Invasive Fungal Infections (1) · Multiple Sclerosis (1) · Mycobacterium Infections (1) · Neutropenia (1) · Sarcoma, Kaposi (1)
Immune System Diseases (14) · Infections (12) · Virus Diseases (8) · Blood-Borne Infections (7) · Communicable Diseases (7) · Genital Diseases (7) · Immunologic Deficiency Syndromes (7) · Lentivirus Infections (7) · RNA Virus Infections (7) · Retroviridae Infections (7) · Sexually Transmitted Diseases (7) · Sexually Transmitted Diseases, Viral (7) · Slow Virus Diseases (7) · Urogenital Diseases (7) · Bacterial Infections and Mycoses (6)
Atorvastatin (1) · Calcium Dobesilate (1) · Dexamethasone (1) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (1) · Maraviroc (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Naproxen (1) · Prednisolone (1) · Prednisone (1) · Valganciclovir (1) · efavirenz (1)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Assistance Publique - Hôpitaux de Paris (1) · Biogen (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (1) · National Institute of Cancerología (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · University Hospital, Basel, Switzerland (1) · University of Cape Town (1) · University of Minnesota (1) · University of Washington (1)
United States (6) · Mexico (3) · South Africa (2) · Thailand (2) · France (1) · Gabon (1) · Germany (1) · Kenya (1) · Lesotho (1) · Malawi (1)
Irini Sereti, M.D. (2) · David R Boulware, MD, MPH (1) · Grace John Stewart, MD, PhD (1) · Graeme Meintjes, MD MPH PhD (1) · Ian Sanne, MBBCH, FCP (1) · Irene CM Cortese, M.D. (1) · Irini Sereti, M.D., MHS (1) · Juan G Sierra Madero, MD (1) · Livio Azzoni, MD, PhD (1) · Luis J Montaner, M.Sc. (1) · MP Grobusch, MD, MSc (1) · Maura M Manion, M.D. (1) · Michael M. Lederman, MD (1) · Niklaus Labhardt, Prof. Dr. DTM&H, MIH (1)
PMID 37040388, PMID 38564303, PMID 20660788, PMID 22219223, PMID 26366430, PMID 27308805, PMID 28609404, PMID 29150377, PMID 29324985, PMID 30215671, PMID 30428290, PMID 31095004, PMID 31879764, PMID 32016127, PMID 32493198, PMID 32761193, PMID 33336253, PMID 35812431, PMID 36606049, PMID 38016160, PMID 38330045, PMID 38941593, PMID 41692011
R01HD023412 (1)