8 completed, 1 active not recruiting, 1 not yet recruiting, 1 recruiting. 13 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 8, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 2 | 2 | Active not recruiting 1, Completed 1 |
Follow Primary Open Angle Glaucoma: new trials by email Literature Review of Primary Open Angle Glaucoma trials Research Report on Primary Open Angle Glaucoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of DNN.31.19.026 for Ocular Hypertension or Primary Open-Angle Glaucoma Product DNN.31.19.026, COSOPT® - Ocular Hypertension, Primary Open Angle Glaucoma | Phase 3 | Not yet recruiting | Ache Laboratorios Farmaceuticos S.A. | 336 | 2026-06-01 | 2026-06-01 |
| A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma XEN63 Glaucoma Treatment System - Primary Open Angle Glaucoma | Phase 3 | Recruiting | AbbVie | 130 | 2025-02-11 | 2026-10-09 |
| Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study Dietary supplements - Nicotinamide and Pyruvate, Placebo - Primary Open Angle Glaucoma | Phase 2 / Phase 3 | Active not recruiting | Columbia University | 250 | 2023-03-14 | 2026-07-15 |
| A Therapeutic Equivalence Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension Brinzolamide ophthalmic suspension, Azopt® - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Sun Pharmaceutical Industries Limited | 599 | 2021-12-20 | 2024-01-18 |
| A Study of Efficacy and Safety of PHP-201 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension Placebo ophthalmic solution, PHP-201 ophthalmic solution - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Unknown | pH Pharma | 110 | 2021-11-01 | 2021-06-18 |
| Efficacy and Safety Study of Netarsudil 0.02% Ophthalmic Solution Compared to Ripasudil Hydrochloride Hydrate 0.4% Ophthalmic Solution in Japanese Subjects With Primary Open Angle Glaucoma or Ocular Hypertension Netarsudil ophthalmic solution 0.02%, Ripasudil hydrochloride hydrate ophthalmic solution 0.4% - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Aerie Pharmaceuticals | 245 | 2020-11-30 | 2023-02-27 |
| Non-inferiority of PRO-122 Ophthalmic Solution vs KRYTANTEK Ofteno® in Glaucoma or Ocular Hypertension (CONFORTK) PRO-122, Krytantek Ofteno® - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Laboratorios Sophia S.A de C.V. | 60 | 2016-04-01 | 2019-12-09 |
| A Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension -AYAME Study- Placebo ophthalmic solution, DE-117 ophthalmic solution low, DE-117 ophthalmic solution high - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 / Phase 3 | Completed | Santen Pharmaceutical Co., Ltd. | 253 | 2015-12-06 | 2017-11-20 |
| Non-inferiority of PRO-067 Ophthalmic Solution vs GAAP Ofteno® in Glaucoma or Ocular Hypertension PRO-067, GAAP Ofteno® - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Terminated | Laboratorios Sophia S.A de C.V. | 116 | 2015-09-01 | 2024-07-05 |
| Safety and Efficacy of T-2345 Compared to Xalatan in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension T-2345, Xalatan - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Nephron Pharmaceuticals Corporation | 335 | 2014-01-01 | 2018-08-22 |
| A Study of Ganfort Versus Duotrav in Patients With Primary Open Angle Glaucoma or Ocular Hypertension Ganfort, Duotrav - Ocular Hypertension, Primary Open Angle Glaucoma | Phase 3 | Completed | Ministry of Health, Malaysia | 42 | 2010-08-01 | 2011-07-08 |
| 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination travoprost/timolol fixed combination, placebo (artificial tears) - Primary Open Angle Glaucoma, Exfoliation Syndrome | Phase 3 | Completed | Aristotle University Of Thessaloniki | 32 | 2006-03-01 | 2014-05-12 |
| Intraoperative 5-fluorouracil Augmentation of Trabeculectomy 5-fluorouracil, placebo - Glaucoma, Primary Open Angle Glaucoma | Phase 3 | Completed | Moorfields Eye Hospital NHS Foundation Trust | 368 | 1996-04-01 | 2024-12-20 |
Glaucoma, Open-Angle (13) · Ocular Hypertension (9) · Glaucoma (4) · Exfoliation Syndrome (1)
Eye Diseases (13) · Glaucoma (9) · Ocular Hypertension (4) · Iris Diseases (1) · Uveal Diseases (1)
Latanoprost (3) · Brimonidine Tartrate (1) · Duotrav (1) · Fluorouracil (1) · Ganfort (1) · Lubricant Eye Drops (1) · Prostaglandins (1) · Pyruvic Acid (1) · Sodium Chloride (1) · Timolol (1) · Travoprost (1) · brinzolamide (1) · dorzolamide (1) · dorzolamide-timolol combination (1) · sovesudil (1)
Laboratorios Sophia S.A de C.V. (2) · AbbVie (1) · Ache Laboratorios Farmaceuticos S.A. (1) · Aerie Pharmaceuticals (1) · Aristotle University Of Thessaloniki (1) · Columbia University (1) · Ministry of Health, Malaysia (1) · Moorfields Eye Hospital NHS Foundation Trust (1) · Nephron Pharmaceuticals Corporation (1) · Santen Pharmaceutical Co., Ltd. (1) · Sun Pharmaceutical Industries Limited (1) · pH Pharma (1)
United States (3) · Japan (2) · Greece (1) · India (1) · Malaysia (1) · Mexico (1) · Russia (1) · South Korea (1)
Aakriti G. Shukla, MD (1) · Joella Kittrell (1) · Younyoung Hwang (1)