17 completed, 6 unknown, 1 active not recruiting, 1 enrolling by invitation. 26 Phase 2, 5 Phase 1, 2 Phase 3.
Follow Primary Open Angle Glaucoma: new trials by email Literature Review of Primary Open Angle Glaucoma trials Research Report on Primary Open Angle Glaucoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Insulin for Glaucoma (TING2) EYED-002 Low Dose (721 U/mL topical insulin), EYED-002 High Dose (1442 U/mL topical insulin), EYED-002 (highest tolerated dose, 12-month) - Open Angle Glaucoma, Primary Open Angle Glaucoma | Phase 1 / Phase 2 | Enrolling by invitation | Stanford University | 90 | 2026-09-10 | 2026-10-13 |
| A Randomized, Open-label, Active-controlled, Phase 2a Clinical Trial to Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-angle Glaucoma or Ocular Hypertension TFC-003, COSOPT ophthalmic solution - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Unknown | Kukje Pharma | 60 | 2024-02-01 | 2023-12-20 |
| A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma AMDX-2011P - Primary Open Angle Glaucoma | Phase 2 | Unknown | Amydis Inc. | 50 | 2023-12-07 | 2024-07-30 |
| Ph2 Placebo-Controlled Study for Safety & Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Pts w/ Elevated Eye Pressure SBI-100 Ophthalmic Emulsion, 0.5%, SBI-100 Ophthalmic Emulsion, 1.0%, SBI-100 Ophthalmic Emulsion, Placebo - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Completed | Skye Bioscience, Inc. | 56 | 2023-11-09 | 2026-01-14 |
| Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study Dietary supplements - Nicotinamide and Pyruvate, Placebo - Primary Open Angle Glaucoma | Phase 2 / Phase 3 | Active not recruiting | Columbia University | 250 | 2023-03-14 | 2026-07-15 |
| Study to Evaluate QLS-101 Compared to Timolol Maleate Eye Drops in Subjects With High Eye Pressure (Glaucoma or Ocular Hypertension). QLS-101, Timolol Maleate - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Completed | Qlaris Bio, Inc. | 84 | 2021-03-31 | 2025-01-17 |
| Study of LL-BMT1 in Patients With Elevated Intraocular Pressure LL-BMT1 - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Completed | MediPrint Ophthalmics, Inc. | 5 | 2021-01-08 | 2022-06-08 |
| Multicenter Study Assessing the Efficacy and Safety of DE-126 Ophthalmic Solution 0.002% Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension DE-126 Ophthalmic Solution 0.002% QD, Timolol Maleate Ophthalmic Solution 0.5% BID - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Completed | Santen Inc. | 323 | 2020-12-17 | 2023-06-22 |
| A Clinical Study to Evaluate the Efficacy and Safety of CKD-351 CKD-351, Latanoprost+Dorzolmamide - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Unknown | Chong Kun Dang Pharmaceutical | 100 | 2020-06-11 | 2020-06-25 |
| Study to Assess the Efficacy, Safety and Tolerability of AKB-9778 Ophthalmic Solution as and Adjunct to Latanoprost in Patients With Ocular Hypertension or Open Angle Glaucoma Latanoprost ophthalmic solution, AKB-9778 4%, Placebo - Ocular Hypertension, Primary Open Angle Glaucoma | Phase 2 | Completed | EyePoint Pharmaceuticals, Inc. | 194 | 2020-06-06 | 2023-05-25 |
| Ahmed Glaucoma Valve Surgery With Mitomycin-C Mitomycin-C, Balanced Salt Solution, Ahmed Glaucoma Valve Implant - Glaucoma, Primary Open Angle Glaucoma | Phase 2 | Completed | University of California, San Francisco | 119 | 2016-06-01 | 2022-05-31 |
| A Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension -AYAME Study- Placebo ophthalmic solution, DE-117 ophthalmic solution low, DE-117 ophthalmic solution high - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 / Phase 3 | Completed | Santen Pharmaceutical Co., Ltd. | 253 | 2015-12-06 | 2017-11-20 |
| Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging 7-Tesla MRI, Optical Coherence Tomography, Heidelberg Retina Tomography - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Terminated | Medical University of Vienna | 120 | 2015-11-01 | 2019-08-22 |
| Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion. Pulsed Electromagnetic Field Therapy, Seawater eyedrops - Primary Open Angle Glaucoma, Hypertension Ocular | Phase 1 / Phase 2 | Unknown | American Society Of Thermalism And Climatology Inc | 100 | 2014-11-01 | 2015-06-23 |
| The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy With Ex-PRESS Glaucoma Filtration Device Placement of the sponge, Mitomycin-C - Primary Open Angle Glaucoma | Phase 2 | Completed | Duke University | 100 | 2014-03-01 | 2018-02-09 |
| Study to Compare the Safety and Efficacy of ALZ-1101 to Latanoprost in Patients With Intraocular Pressure Inadequately Controlled by Latanoprost ALZ-1101, Latanoprost - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Completed | Alleanza Pharmaceuticals, Inc. | 63 | 2013-07-01 | 2014-09-30 |
| ATS907 Ph2a Open-Label Dose-ranging Safety and Tolerability in Primary Open Angle Glaucoma (POAG) and Ocular Hypertension (OHT) Subjects ATS907 - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Completed | Altheos, Inc. | 12 | 2012-08-01 | 2012-09-07 |
| Study of the Safety and Efficacy of ATS907 in Subjects With Primary Open Angle Glaucoma (POAG) and Ocular Hypertension Stage 1 - ATS907 - Dose 1, Stage 1 - ATS907 - Dose 2, Stage 1 - ATS907 - Dose 3 - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 1 / Phase 2 | Unknown | Altheos, Inc. | 180 | 2012-01-01 | 2012-11-01 |
| Transconjunctival Needling Revision Versus Medical Treatment Transconjunctival needling revision, Medical treatment - Primary Open Angle Glaucoma | Phase 2 | Completed | University of Sao Paulo General Hospital | 40 | 2010-05-01 | 2013-06-27 |
| Safety and Efficacy Study of the Hydrus Aqueous Implant in Subjects With POAG prestudy topical glaucoma medications - Primary Open Angle Glaucoma | Phase 1 / Phase 2 | Completed | Ivantis, Inc. | 120 | 2010-03-01 | 2019-02-04 |
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Glaucoma, Open-Angle (26) · Ocular Hypertension (18) · Glaucoma (8) · Low Tension Glaucoma (2) · Exfoliation Syndrome (1) · Glaucoma, Neovascular (1)
Eye Diseases (26) · Glaucoma (18) · Ocular Hypertension (8) · Optic Nerve Diseases (2) · Iris Diseases (1) · Uveal Diseases (1)
Latanoprost (6) · Mitomycin (2) · Timolol (2) · BID protein, human (1) · Brimonidine Tartrate (1) · Hanks Balanced Salt Solution (1) · Insulin (1) · Prostaglandins (1) · Pyruvic Acid (1) · Tomography, Optical Coherence (1) · dorzolamide (1) · dorzolamide-timolol combination (1) · epigallocatechin gallate (1)
Altheos, Inc. (2) · Bausch & Lomb Incorporated (2) · Alleanza Pharmaceuticals, Inc. (1) · American Society Of Thermalism And Climatology Inc (1) · Amydis Inc. (1) · Catholic University of the Sacred Heart (1) · Chong Kun Dang Pharmaceutical (1) · Columbia University (1) · Duke University (1) · EyePoint Pharmaceuticals, Inc. (1) · Ivantis, Inc. (1) · Kukje Pharma (1) · Laboratoires Thea (1) · Laboratorios Sophia S.A de C.V. (1) · MediPrint Ophthalmics, Inc. (1)
United States (15) · Mexico (3) · Austria (2) · Japan (2) · South Korea (2) · Australia (1) · Brazil (1) · China (1) · Czechia (1) · France (1) · Germany (1) · Greece (1) · India (1) · Italy (1) · Pakistan (1)
Aakriti G. Shukla, MD (1) · Barbara Wirostko, MD (1) · Benedetto Falsini, MD (1) · Dario Marangoni, M.D. (1) · David Bingaman (1) · Garis Silega (1) · Gerhard Garhoefer, MD (1) · Jeffrey L Goldberg, MD PhD (1) · Ken Harper (1) · Kenneth Harper (1) · KiHo Park, MD (1) · Leon Herndon, MD (1) · Leopoldo M Baiza-Duran, MD (1) · Prof. Dr. Manfred Tetz, MD (1)
PMID 10201583, PMID 10664926, PMID 12049574, PMID 19290537, PMID 2194358, PMID 22207522, PMID 22607109, PMID 24212847, PMID 27310103, PMID 2806924, PMID 29189540, PMID 32533949, PMID 38536128, PMID 40043909, PMID 9261306