3 enrolling by invitation. 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Enrolling by invitation 3 |
Follow Primary Dysautonomias: new trials by email Literature Review of Primary Dysautonomias trials Research Report on Primary Dysautonomias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Open-Label Access to ATH434 for Patients Who Completed Study ATH434-201 in France ATH434 - Multiple System Atrophy | Phase 2 | Enrolling by invitation | Alterity Therapeutics | 7 | 2026-10-01 | 2026-10-09 |
| Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia Matching placebo, Dexmedetomidine - Familial Dysautonomia | Phase 2 | Enrolling by invitation | NYU Langone Health | 15 | 2024-07-01 | 2026-04-13 |
| Droxidopa / Pyridostigmine in Orthostatic Hypotension Droxidopa, Pyridostigmine, Placebo - Orthostatic Hypotension | Phase 2 | Enrolling by invitation | Mayo Clinic | 30 | 2011-11-01 | 2026-07-15 |
Dysautonomia, Familial (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Hypotension, Orthostatic (1) · Multiple System Atrophy (1)
Autonomic Nervous System Diseases (3) · Nervous System Diseases (3) · Neurodegenerative Diseases (2) · Basal Ganglia Diseases (1) · Brain Diseases (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Genetic Diseases, Inborn (1) · Heredodegenerative Disorders, Nervous System (1) · Hypotension (1) · Movement Disorders (1) · Nervous System Malformations (1)
8-hydroxyquinazolin-4(3H)-one (1) · ATH434 (1) · Dexmedetomidine (1) · Droxidopa (1) · Pyridostigmine Bromide (1)
Alterity Therapeutics (1) · Mayo Clinic (1) · NYU Langone Health (1)
United States (2) · France (1)
Alejandra Gonzalez-Duarte, MD (1) · Wolfgang Singer, M.D. (1)
2025 (1), P01NS044233 (1)