6 recruiting, 5 completed, 3 unknown, 1 active not recruiting. 7 Phase 2, 3 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 4, Recruiting 2, Unknown 1 |
| Early Phase 1 | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
Follow POEMS Syndrome: new trials by email Literature Review of POEMS Syndrome trials Research Report on POEMS Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| KCD (Carfilzomib/Cyclophosphamide/Dexamethasone) Regimen for the Treatment of Newly Diagnosed POEMS Syndrome CARFILZOMIB, CYCLOPHOSPHAMIDE, DEXAMETHASONE - POEMS Syndrome | Phase 2 | Recruiting | Shanghai Changzheng Hospital | 20 | 2026-06-15 | 2026-06-17 |
| One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS AL Amyloidosis, POEMS Syndrome | Recruiting | Fondazione IRCCS Policlinico San Matteo di Pavia | 100 | 2025-11-28 | 2026-05-06 | |
| BCMA/CD3 BsAb Therapy for POEMS Syndrome CM336 (BCMA/CD3 bispecific antibody) - POEMS Syndrome | Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 10 | 2025-08-04 | 2026-09-29 |
| A Study of KQ-2003 CAR-T Cell Therapy for Patients With Relapsed or Refractory POEMS Syndrome KQ-2003 CAR T-cells - POEMS Syndrome | Phase 1 | Not yet recruiting | Novatim Immune Therapeutics (Zhejiang) Co., Ltd. | 21 | 2024-08-31 | 2024-07-24 |
| Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study Validity and reliability of outcome measures in polyneuropathy, Healthy controls - Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy | Active not recruiting | Copenhagen University Hospital, Rigshospitalet | 520 | 2023-09-23 | 2026-09-15 | |
| To Evaluate Efficacy of Red Dichromatic Imaging (RDI) in Achieving Hemostasis During POEM Using GF 1500 UGI Scope White Light Imaging, Red Light Imaging - POEMS Syndrome, Hemostatic Disorder | Unknown | Asian Institute of Gastroenterology, India | 100 | 2022-08-15 | 2023-05-31 | |
| A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis CD19/BCMA CAR T-cells - POEMS Syndrome, Amyloidosis | Early Phase 1 | Unknown | Zhejiang University | 75 | 2021-10-08 | 2022-03-03 |
| A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH No intervention - Multiple Myeloma, Amyloidosis | Recruiting | Peking University First Hospital | 2000 | 2021-07-01 | 2026-09-16 | |
| Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Inflammatory Diseases of the Nervous System CT103A cells, Cyclophosphamide and fludarabine - Autoimmune Diseases, Autoimmune Diseases of the Nervous System | Early Phase 1 | Recruiting | Tongji Hospital | 36 | 2020-09-22 | 2024-10-30 |
| Treatment of POEMS Syndrome With Daratumumab Daratumumab Injection - POEMS Syndrome | Phase 2 | Completed | University of Arkansas | 2 | 2020-09-22 | 2023-11-13 |
| Registry for Adults With Plasma Cell Disorders (PCD's) Multiple Myeloma, Amyloidosis | Recruiting | UNC Lineberger Comprehensive Cancer Center | 2000 | 2018-02-09 | 2025-11-20 | |
| Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Dexamethasone, Ixazomib Citrate, Lenalidomide - Plasmacytoma, POEMS Syndrome | Early Phase 1 | Completed | Mayo Clinic | 21 | 2016-10-31 | 2025-02-12 |
| Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome Trial Lenalidomide+Dexamethasone - POEMS Syndrome | Phase 2 | Completed | Chiba University | 5 | 2014-07-01 | 2016-07-29 |
| Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS Syndrome Lenalidomide, Dexamethasone - POEMS Syndrome | Phase 2 | Completed | Peking Union Medical College Hospital | 41 | 2014-03-01 | 2017-04-25 |
| POEMS Syndrome Treatment With Lenalidomide Lenalidomide and dexamethasone - POEMS Syndrome | Phase 2 | Completed | University Hospital, Limoges | 51 | 2012-07-01 | 2026-08-31 |
| The Treatment of Lenalidomide in Patients With POEMS Syndrome Lenalidomide and dexamethasone - POEMS Syndrome | Phase 2 | Unknown | Istituto Clinico Humanitas | 16 | 2009-07-01 | 2010-09-02 |
Amyloidosis (3) · Multiple Myeloma (3) · Castleman Disease (2) · Cryoglobulinemia (2) · Leukemia, Plasma Cell (2) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (2) · Smoldering Multiple Myeloma (2) · Anemia, Hemolytic, Autoimmune (1) · Autoimmune Diseases (1) · Autoimmune Diseases of the Nervous System (1) · Charcot-Marie-Tooth Disease (1) · Diabetic Neuropathies (1) · Hemostatic Disorders (1) · Immunoglobulin Light-chain Amyloidosis (1)
Abnormalities, Multiple (16) · Blood Protein Disorders (16) · Congenital Abnormalities (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Hematologic Diseases (16) · Hemic and Lymphatic Diseases (16) · Immune System Diseases (16) · Immunoproliferative Disorders (16) · Nervous System Diseases (16) · Neuromuscular Diseases (16) · Paraproteinemias (16) · Peripheral Nervous System Diseases (16) · Polyneuropathies (15) · Neoplasms (6) · Cardiovascular Diseases (5)
Dexamethasone (5) · Lenalidomide (4) · Cyclophosphamide (2) · Calcium Dobesilate (1) · auricularum (1) · carfilzomib (1) · daratumumab (1) · dexamethasone 21-phosphate (1) · dexamethasone acetate (1) · fludarabine (1) · ixazomib (1)
Asian Institute of Gastroenterology, India (1) · Chiba University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Istituto Clinico Humanitas (1) · Mayo Clinic (1) · Novatim Immune Therapeutics (Zhejiang) Co., Ltd. (1) · Peking Union Medical College Hospital (1) · Peking University First Hospital (1) · Shanghai Changzheng Hospital (1) · Tongji Hospital (1) · UNC Lineberger Comprehensive Cancer Center (1) · University Hospital, Limoges (1) · University of Arkansas (1)
China (7) · United States (3) · Italy (2) · Denmark (1) · France (1) · India (1) · Japan (1)
Angela Dispenzieri, M.D. (1) · Armando Santoro, MD (1) · Britt S Pedersen (1) · Dao-bin Zhou, MD (1) · Frits van Rhee, MD (1) · Haiyan He, Dr. (1) · He Huang, PhD (1) · Jian Li, M.D. (1) · Mohan Ramchandani, MBBS (1) · Sascha Tuchman, MD (1) · Sonoko Misawa, MD (1) · Wei Wang, MD (1)
PMID 29603764, PMID 32429967, PMID 34025681, PMID 37658205, PMID 40425008, PMID 41101309