18 completed. 18 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 18 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
Follow Pertussis: new trials by email Literature Review of Pertussis trials Research Report on Pertussis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trials of Adsorbed Cell-free DPT Vaccine (Five-component) Tetanus, Reduced Diphtheria and Acellular Pertussis (Five Components) Combined Vaccine, Adsorbed (Tdcp)), 23-valent Pneumococcal Polysaccharide Vaccine (PPV23), Tdcp - Diphtheria, Tetanus | Phase 2 / Phase 3 | Completed | CanSino Biologics Inc. | 1820 | 2024-12-20 | 2026-08-26 |
| Maternal Pertussis Wholecell Responses Standard of care vaccines, Boostagen, (BioNet-Asia) - Pertussis | Phase 2 | Completed | St George's, University of London | 181 | 2020-10-21 | 2023-11-22 |
| Study of BPZE1 Intranasal Pertussis Vaccine (Administered Via VaxINator(TM)), Prime + Boost, in Healthy Adults BPZE1 pertussis vaccine and VaxINator(TM) Atomization Device - Pertussis, Whooping Cough | Phase 2 | Completed | ILiAD Biotechnologies | 300 | 2019-06-15 | 2023-06-27 |
| Study on the Safety and Immunogenicity of Boostrix Vaccine in Pregnant Malian Women and Their Infants Tetanus and Diphtheria Toxoids Adsorbed, Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed onto aluminum hydroxide - Clostridium Difficile Immunisation, Diphtheria | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 399 | 2019-01-24 | 2025-05-21 |
| Safety and Immunogenicity of Intranasal BPZE1 Vaccination in Healthy Adults BPZE1, Placebo - Pertussis, Pertussis Immunisation | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 50 | 2018-10-23 | 2024-09-19 |
| Study to Evaluate the Immunogenicity and Safety of LBVD(Hexavalent Vaccine), Given to Healthy Infants at Primary Series LBVD (Hexavalent vaccine), Pentavalent vaccine and Inactivated Polio vaccine (Sabin strains) - Diphtheria, Tetanus | Phase 2 / Phase 3 | Completed | LG Chem | 60 | 2018-07-18 | 2026-09-03 |
| The PertADO Geneva Trial Pertagen® aP + Td-pur®, Boostrix® dTpa - Pertussis | Phase 2 | Completed | Siegrist Claire-Anne | 60 | 2016-10-27 | 2017-05-08 |
| Maternal Tdap Immunization in Guatemala Tdap, Td - Pertussis, Whooping Cough | Phase 2 | Completed | Emory University | 286 | 2016-07-01 | 2019-10-16 |
| Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed Formulation 1, Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed, Formulation 2, Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed, Formulation 3 - Tetanus, Diphtheria | Phase 1 / Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 1363 | 2015-10-22 | 2022-03-23 |
| Study of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine (ADACEL®) as a Booster in Adolescents (ADACEL®): Tetanus, Reduced Diphtheria Toxoid and Acellular Pertussis - Pertussis, Tetanus | Phase 1 / Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 43 | 2012-09-01 | 2014-02-21 |
| Study of Menactra® in Children Aged 4 to 6 Years When Administered Concomitantly With a Fifth Dose of DAPTACEL® Polysaccharide Diphtheria Toxoid Conjugate Vaccine - Meningococcal Meningitis, Tetanus | Phase 2 | Completed | Sanofi | 882 | 2006-10-01 | 2011-08-24 |
| Study of PR5I, a Pediatric Combination Vaccine With Enhanced Hepatitis B Component Given Concomitantly With Prevnar® Hybrid 5 component DTaP, Vero IPV, Hep B and PRP-OMPC - Diphtheria, Pertussis | Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 460 | 2006-08-01 | 2014-01-14 |
| Pentavalent DTaP-Hep B-IPV DTaP-Hep B-IPV Vaccine, Monovalent Hep B Vaccine, Placebo - Diphtheria, Hepatitis B | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 5 | 2005-12-01 | 2011-11-07 |
| Immune Memory Foll Pry Vaccination With DTPw-HBV/Hib Vaccine Formulation; Immuno & Reacto of Booster Dose at 15-18 Mths Diphteria, tetanus, whole-cell pertussis, hepatitis B & Hib - Hib Disease, Hepatitis B | Phase 2 | Completed | GlaxoSmithKline | 175 | 2005-01-01 | 2017-05-30 |
| Study of DTaP-IPV-Hep B-PRP~T Combined Vaccine Compared With PENTAXIM™ and ENGERIX B® PEDIATRICO in Argentinean Infants DTaP-IPV-HB-PRP~T, DTaP-IPV//PRP~T combined vaccine & Recombinant hep B vaccine - Diphtheria, Tetanus | Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 624 | 2004-10-01 | 2013-12-17 |
| Assess Immune Response Following Primary Vaccination With Tritanrix™-HepB Vaccine Mixed With 3 Formulations of Hib-MenAC Vaccine to Infants DTPw-HBV/Hib-MenAC conjugate vaccine - Diphtheria, Tetanus | Phase 2 | Completed | GlaxoSmithKline | 525 | 2002-11-01 | 2006-12-08 |
| Study of Tetanus and Diphtheria Toxoids Adsorbed Combined With Component Pertussis Vaccine and Inactivated Poliomyelitis Tetanus and Diphtheria Toxoids Adsorbed Combined with Component Pertussis Vaccine and IPV, Hepatitis B vaccine - Pertussis, Tetanus | Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 277 | 1999-01-01 | 2015-03-25 |
| Immunogenicity and Safety of DTPa-HBV-IPV/Hib Compared to DTPa-IPV/Hib and HBV Administered Concomitantly DTPa-HBV-IPV/Hib (Infanrix-hexa™), DTPa-IPV/Hib (Infanrix-IPV/Hib™), HBV (Engerix™-B) - Hepatitis B, Diphtheria | Phase 2 | Completed | GlaxoSmithKline | 312 | 1998-09-01 | 2017-06-16 |
Whooping Cough (18) · Tetanus (13) · Diphtheria (12) · Hepatitis B (8) · Poliomyelitis (7) · Haemophilus Infections (4) · Bordetella Infections (1) · Gram-Negative Bacterial Infections (1) · Infections (1) · Meningitis, Meningococcal (1) · Respiratory Tract Diseases (1) · Respiratory Tract Infections (1)
Bacterial Infections (18) · Bacterial Infections and Mycoses (18) · Bordetella Infections (17) · Gram-Negative Bacterial Infections (17) · Infections (17) · Respiratory Tract Diseases (17) · Respiratory Tract Infections (17) · Clostridium Infections (13) · Gram-Positive Bacterial Infections (13) · Actinomycetales Infections (12) · Corynebacterium Infections (12) · Virus Diseases (9) · Blood-Borne Infections (8) · Communicable Diseases (8) · DNA Virus Infections (8)
Tetanus Toxoid (5) · Diphtheria-Tetanus-acellular Pertussis Vaccines (2) · Hepatitis B Vaccines (2) · Poliovirus Vaccine, Inactivated (2) · Vaccines, Combined (2) · adacel (2) · Boostrix (1) · DTaP-IPV-HB-PRP-T vaccine (1) · Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate (1) · Haemophilus influenzae-type b polysaccharide-Neisseria meningitidis outer membrane protein conjugate vaccine (1) · Meningococcal Vaccines (1) · Pentavac (1) · Recombivax HB (1) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (1) · pentacel (1)
Sanofi Pasteur, a Sanofi Company (5) · GlaxoSmithKline (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · CanSino Biologics Inc. (1) · Emory University (1) · ILiAD Biotechnologies (1) · LG Chem (1) · Sanofi (1) · Siegrist Claire-Anne (1) · St George's, University of London (1)
United States (6) · Canada (2) · Philippines (2) · Argentina (1) · China (1) · Guatemala (1) · Japan (1) · Mali (1) · South Korea (1) · Switzerland (1) · Uganda (1)
Barbara Rizzardi, MD (1) · Claire-Anne Siegrist, MD (1) · Edison Alberto, MD (1) · Hanqing He (1) · Josefina Carlos, MD (1) · Kirsty Le Doare, MBBS, PhD (1) · Manish Sadarangani, MRCPCH, DPHIL, BM.BCh, MA (1) · Mary B Manning, MD (1) · Saad B. Omer, MBBS,MPH,PhD (1) · Vicki Miller, MD (1)
PMID 20657177, PMID 21372751, PMID 23241989, PMID 24346596, PMID 25540274, PMID 30759183, PMID 36906345, PMID 38586589, PMID 39706666