15 completed, 8 unknown, 3 recruiting, 3 terminated. 13 Not applicable, 6 Phase 4, 1 Early Phase 1, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Unknown 7, Completed 4, Recruiting 1, Withdrawn 1 |
| Phase 4 | 6 | Completed 4, Terminated 2 |
| Early Phase 1 | 1 | Terminated 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Penicillin Allergy: new trials by email Literature Review of Penicillin Allergy trials Research Report on Penicillin Allergy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Digital Stewardship Strategy for Patients With Reported Penicillin Allergy Penicillin Allergy, In-hospital Process Optimization | Completed | Althaia Xarxa Assistencial Universitària de Manresa | 182 | 2025-09-04 | 2026-05-29 | |
| Provocation After Nurse-Directed Assessment (PANDA) Study Nurse-led penicillin allergy delabelling service, Allergist-led penicillin allergy delabelling service - Drug Allergy, Penicillin Allergy | Recruiting | The University of Hong Kong | 440 | 2025-09-01 | 2026-04-29 | |
| Risk-stratified Testing for Safe Removal of Penicillin Allergy Labels Direct Oral challenge, standard of care - Penicillin Allergy, Hypersensitivity, Immediate | Not applicable | Recruiting | Deniz Göcebe | 100 | 2025-01-08 | 2025-04-10 |
| Evaluating the Feasibility of High-volume, Low-risk Penicillin Allergy De-labelling to Maximise Efficiency in a Resource-limited Setting Single dose low-risk penicillin challenge - Penicillin Allergy | Not applicable | Unknown | University Hospital Southampton NHS Foundation Trust | 36 | 2024-10-01 | 2024-08-05 |
| Removal of Erroneous Penicillin Allergy Labels: Implementation Study (REPeAL) Penicillin Allergy | Unknown | Royal Cornwall Hospitals Trust | 30 | 2024-06-18 | 2024-07-30 | |
| Geisinger Antibiotic Allergy Pilot Program: Assess and Address Amoxicillin - Penicillin Allergy | Early Phase 1 | Terminated | Geisinger Clinic | 20 | 2024-03-04 | 2026-07-20 |
| Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge Amoxicillin 250 MG, Placebo, Amoxicillin 62.5mg - Penicillin Allergy | Phase 3 | Recruiting | James Tarbox, MD | 380 | 2024-02-03 | 2025-05-01 |
| Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients Amoxicillin 250 MG - Penicillin Allergy | Not applicable | Unknown | Saskatchewan Health Authority - Regina Area | 50 | 2023-12-01 | 2023-04-13 |
| Penicillin Allergy Delabeling Among Surgical Patients Allergy testing - Penicillin Allergy | Not applicable | Unknown | University Medicine Greifswald | 600 | 2023-09-01 | 2023-07-21 |
| Impact of Pre-operative Penicillin Allergy Evaluation on Surgical Prophylaxis Detailed penicillin allergy evaluation - Penicillin Allergy, Surgical Prophylaxis | Not applicable | Unknown | Chinese University of Hong Kong | 68 | 2023-04-01 | 2023-04-21 |
| Oral Penicillin Challenge and Allergy De-labeling in Children Amoxicillin 500mg - Penicillin Allergy | Phase 4 | Terminated | Phoenix Children's Hospital | 31 | 2022-09-26 | 2024-06-14 |
| Penicillin De-labeling in the Pediatric Primary Care Setting Amoxicillin - Penicillin Allergy, Penicillin Reaction | Phase 4 | Completed | University of Texas Southwestern Medical Center | 23 | 2021-12-09 | 2024-08-14 |
| A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes Penicillin Allergy, Antimicrobial Drug Resistance | Active not recruiting | University of Leeds | 214 | 2021-11-30 | 2025-09-17 | |
| Inpatient Penicillin Allergy Delabeling Study Graded Oral Amoxicillin Challenge, De-labelling in electronic medical record, Referral to Allergy Immunology/Retention of Allergy Label - Penicillin Allergy, Penicillin Sensitivity | Phase 4 | Completed | University Hospitals Cleveland Medical Center | 40 | 2021-09-22 | 2023-07-20 |
| Penicillin Allergy Delabeling Project Risk stratification - Penicillin Allergy | Not applicable | Completed | Haukeland University Hospital | 153 | 2021-07-28 | 2024-02-09 |
| Penicillin Allergy Testing in STD Clinics Penicillin Major Determinant (PrePen) Skin Testing, Direct Oral challenge - Penicillin Allergy | Phase 4 | Completed | Johns Hopkins University | 284 | 2021-06-01 | 2023-09-21 |
| The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal Penicillin Allergic Risk Stratification Best Practice Alert - Penicillin Allergy | Not applicable | Completed | Vanderbilt University Medical Center | 2052 | 2020-11-11 | 2024-12-18 |
| Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy Penicillin Allergy Risk Stratification and Evaluation - Penicillin Allergy | Completed | Vanderbilt University Medical Center | 20 | 2020-09-15 | 2021-06-30 | |
| Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting Penicillin Allergic Risk Stratification Best Practice Alert - Penicillin Allergy | Not applicable | Completed | Vanderbilt University Medical Center | 240 | 2019-03-31 | 2022-05-13 |
| Penicillin Allergy Testing and Resensitization Rate Behavioral allergy testing protocol - Penicillin Allergy | Completed | Centre Hospitalier Régional Metz-Thionville | 83 | 2019-02-01 | 2019-07-31 |
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Drug Hypersensitivity (5) · Hypersensitivity (4) · Anaphylaxis (1) · Communicable Diseases (1) · Drug-Related Side Effects and Adverse Reactions (1) · Emergencies (1) · Hypersensitivity, Delayed (1) · Hypersensitivity, Immediate (1)
Chemically-Induced Disorders (5) · Immune System Diseases (5) · Drug-Related Side Effects and Adverse Reactions (4) · Disease Attributes (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Hypersensitivity (1) · Hypersensitivity, Immediate (1) · Infections (1)
Amoxicillin (7) · Skin Tests (2) · Anti-Bacterial Agents (1) · Electronic Health Records (1) · Intradermal Tests (1) · Monobactams (1) · Penicillins (1) · Population Groups (1) · Standard of Care (1) · WW Domain-Containing Oxidoreductase (1)
Vanderbilt University Medical Center (3) · Chulalongkorn University (2) · Althaia Xarxa Assistencial Universitària de Manresa (1) · CHU de Quebec-Universite Laval (1) · Centre Hospitalier Régional Metz-Thionville (1) · Chinese University of Hong Kong (1) · Clalit Health Services (1) · Deniz Göcebe (1) · Geisinger Clinic (1) · Haukeland University Hospital (1) · Hillel Yaffe Medical Center (1) · Imperial College London (1) · James Tarbox, MD (1) · Johns Hopkins University (1) · Joseph D. Tobias (1)
United States (12) · United Kingdom (3) · Hong Kong (2) · Thailand (2) · Canada (1) · France (1) · Germany (1) · Israel (1) · Norway (1) · Spain (1)
Chris Lindsell, PhD (2) · Jettanong Klaewsongkram, MD (2) · Alison H Holmes, MD MPH MBBS (1) · Andrea Fong, MD, FRCPC (1) · Ankita Desai, MD (1) · Arnon Goldberg, MD (1) · Christian S. Scheer, MD (1) · Cosby A Stone, Jr., MD (1) · Cosby Stone, MD, MPH (1) · David E Vyles, DO, MS (1) · Diane E Hindman, MD PharmD (1) · Elina Jerschow, MD, MSc (1) · James A Tarbox, MD (1) · James Antoon, MD, PhD (1) · Jean-Philippe Drolet, MD FRCPC (1)
PMID 27043788, PMID 16461139, PMID 22525392, PMID 23667835, PMID 24188976, PMID 24565482, PMID 26110680, PMID 26505932, PMID 27043299, PMID 28341170, PMID 28483317, PMID 28674112, PMID 28892222, PMID 29361015, PMID 29425903, PMID 29802906, PMID 29803713, PMID 29870460, PMID 29883754, PMID 30209846, PMID 30582497, PMID 30644987, PMID 30753497, PMID 30903298, PMID 31170542, PMID 31216862, PMID 31586667, PMID 32176248, PMID 33849960, PMID 35131513, PMID 35678128, PMID 36122888, PMID 36738783, PMID 37459086, PMID 37868111, PMID 38325290
K12HL137943 (1)