5 recruiting, 3 completed. 3 Phase 4, 2 Phase 2, 1 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 3 | Recruiting 3 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Not applicable | 1 | Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Monobactams: new trials by email Literature Review of Monobactams trials Research Report on Monobactams
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial Beta-lactam antibiotic with spectrum for Enterococcus faecalis, Cephalosporin - Aortic Valve Stenosis | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 1986 | 2026-10-01 | 2026-10-05 |
| Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot Oral Beta-Lactam Antibiotic, Oral Non-Beta-Lactam Antibiotic - Osteomyelitis of Lower Extremities, Osteomyelitis - Foot | Phase 4 | Recruiting | Michael Garron Hospital | 1418 | 2026-02-26 | 2026-03-27 |
| Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children Beta-lactam antibiotic, Beta-lactam model-informed precision dosing - Amoxicillin-clavulanate, Piperacillin-tazobactam | Phase 4 | Recruiting | University Hospital, Ghent | 58 | 2025-07-09 | 2026-09-17 |
| Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge - Drug Allergy, Cephalosporin Allergy | Phase 2 | Recruiting | Massachusetts General Hospital | 300 | 2025-05-05 | 2026-09-04 |
| Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study Beta-lactam antibiotic, Aminoglycoside - Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation | Phase 4 | Recruiting | Chris Goss | 730 | 2023-04-23 | 2026-07-08 |
| Beta-lactam Pharmacokinetics in Secondary Care Beta-lactam antibiotic - Pharmacokinetics, Beta Lactam Adverse Reaction | Completed | Imperial College London | 65 | 2017-07-12 | 2021-08-30 | |
| Investigation of AAI101 Safety, Tolerability & PK in Healthy Volunteers AAI101 i.v., Saline 0.9% infusion, Piperacillin i.v. - Healthy | Phase 1 | Completed | Allecra | 56 | 2013-10-10 | 2018-09-26 |
| Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis Lactobacillus salivarius HN6, Lactobacillus reuteri CR20, Lactobacillus fermentum LC40 - Mastitis | Phase 2 / Phase 3 | Completed | Universidad Complutense de Madrid | 300 | 2008-07-01 | 2009-05-25 |
Anaphylaxis (1) · Aortic Valve Stenosis (1) · Bacteremia (1) · Breast Feeding (1) · Cystic Fibrosis (1) · Drug Hypersensitivity (1) · Hypersensitivity (1) · Mastitis (1) · Osteomyelitis (1)
Allecra (1) · Chris Goss (1) · Copenhagen University Hospital, Rigshospitalet (1) · Imperial College London (1) · Massachusetts General Hospital (1) · Michael Garron Hospital (1) · Universidad Complutense de Madrid (1) · University Hospital, Ghent (1)
Canada (2) · United States (2) · Belgium (1) · Denmark (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Alison H Holmes, MD MPH MBBS (1) · David A Khan, MD (1) · Evelyn Dhont, Dr. (1) · Kimberly G Blumenthal, MD, MSc (1) · Patrick Flume, MD (1)
U01AI184071 (1)