22 unknown, 16 recruiting, 13 completed, 4 not yet recruiting. 22 Phase 2, 11 Not applicable, 6 Phase 3, 3 Phase 1, 1 Early Phase 1.
Follow this condition Literature Review of Oral Squamous Cell Carcinoma trials Research Report on Oral Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-10-26 | 2026-10-21 |
| Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer | Phase 2 | Not yet recruiting | University of Massachusetts, Boston | 65 | 2026-09-01 | 2026-03-19 |
| Neoadjuvant Presurgical Becotatug Vedotin (MRG003) Plus Pucotenlimab (HX008) in Oral Cavity Squamous Cell Carcinoma Becotatug Vedotin (MRG003), Pucotenlimab - Oral Squamous Cell Carcinoma, Head and Neck Cancer | Phase 2 | Not yet recruiting | Sun Yat-sen University | 32 | 2026-09-01 | 2026-08-17 |
| Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction. Patient-specific titanium implants for facial reconstruction - Hemifacial Microsomia, Mucormycosis | Not applicable | Recruiting | Latakia University | 30 | 2026-04-26 | 2026-06-17 |
| Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer Metronidazole, Chlorhexidine - Oral Squamous Cell Carcinoma, Oral Cancer | Phase 2 | Recruiting | Case Comprehensive Cancer Center | 30 | 2025-07-22 | 2026-08-06 |
| Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx Oral Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma | Recruiting | University Hospital, Strasbourg, France | 30 | 2025-07-11 | 2026-01-15 | |
| A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC) Sacituzumab Govitecan, Cetuximab - Squamous Cell Carcinoma of Head and Neck, Sinus Cancer | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 40 | 2025-07-02 | 2026-02-19 |
| People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity Group Meeting (Focus Group), Questionnaires - HIV Infections, Oral Squamous Cell Carcinoma | Active not recruiting | University of California, San Francisco | 133 | 2025-02-13 | 2026-09-11 | |
| Validity of Viome's Oral/throat Cancer Test Oral/Throat cancer test - Oral and Throat Cancer, Oropharyngeal Squamous Cell Carcinoma | Recruiting | Viome | 1000 | 2025-01-27 | 2025-01-29 | |
| A Study Evaluating the Safety and Efficacy of PRV111, PRV211, and PRV131 in Subjects With Oral and Lung Cancers PRV211 (Intraoperative Cisplatin System), PRV111 (Cisplatin Transmucosal System), PRV131 (Cisplatin Intratumoral Injectable) - Oral Squamous Cell Carcinoma | Phase 2 / Phase 3 | Recruiting | Privo Technologies | 40 | 2024-11-07 | 2026-04-23 |
| NBI for Early Diagnosis of OPMD/OSCC Biopsy for diagnostical purposes - Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder | Not applicable | Not yet recruiting | Cardarelli Hospital | 480 | 2024-09-30 | 2024-06-03 |
| SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography OCT (Optical Coherence Tomography) - Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder | Recruiting | University of Palermo | 200 | 2024-03-13 | 2025-05-23 | |
| Neoadjuvant Immunochemotherapy for LAOSCC albumin paclitaxel, cispatin, tislelizumab - Oral Squamous Cell Carcinoma, Locally Advanced Head and Neck Carcinoma | Phase 3 | Recruiting | Lai-ping Zhong | 134 | 2024-02-20 | 2026-09-21 |
| A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma. Three-Week Treatment Regimen with Trastuzumab in Combination with Docetaxel and Platinum Triple Therapy - Oral Squamous Cell Carcinoma | Phase 2 | Unknown | Xuekui Liu | 48 | 2023-11-25 | 2023-11-13 |
| Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcinoma Camrelizumab plus TP, TP - Oral Squamous Cell Carcinoma | Phase 3 | Unknown | Hospital of Stomatology, Wuhan University | 309 | 2023-11-21 | 2024-04-02 |
| Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study ELISA - Oral Cancer, Oral Squamous Cell Carcinoma | Completed | Fayoum University | 46 | 2023-09-03 | 2024-09-27 | |
| WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMA Biopsy Specimens Histopathology - Oral Cancer, Oral Cavity Cancer | Unknown | Armed Forces Institute of Pathology Rawalpindi | 81 | 2023-07-03 | 2023-07-03 | |
| Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT) Tislelizumab, Albumin-Bound Paclitaxel, Cisplatin - Oral Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma | Phase 2 | Active not recruiting | Peking University Hospital of Stomatology | 110 | 2023-06-27 | 2025-06-06 |
| A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors vobramitamab duocarmazine 2.0 mg (Arm A), vobramitamab duocarmazine 2.7 mg (Arm B), vobramitamab duocarmazine - Castration-Resistant Prostatic Cancer, Androgen-Independent Prostatic Cancer | Phase 2 | Terminated | MacroGenics | 192 | 2023-06-13 | 2026-02-09 |
| Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma ：A Single-arm, Prospective, Phase II Trial Tislelizumab, Albumin paclitaxel, Cisplatin - Oral Squamous Cell Carcinoma | Phase 2 | Recruiting | Weijia Fang, MD | 30 | 2023-05-08 | 2023-07-17 |
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Squamous Cell Carcinoma of Head and Neck (59) · Mouth Neoplasms (13) · Head and Neck Neoplasms (6) · Lichen Planus, Oral (3) · Hypopharyngeal Neoplasms (2) · Laryngeal Neoplasms (2) · Leukoplakia, Oral (2) · Oropharyngeal Neoplasms (2) · Stomatitis (2) · Actinic cheilitis (1) · Anus Neoplasms (1) · Carcinoma (1) · Carcinoma in Situ (1) · Carcinoma, Adenoid Cystic (1) · Carcinoma, Non-Small-Cell Lung (1)
Carcinoma, Squamous Cell (59) · Neoplasms (59) · Neoplasms by Histologic Type (59) · Neoplasms by Site (59) · Neoplasms, Glandular and Epithelial (59) · Carcinoma (58) · Head and Neck Neoplasms (53) · Stomatognathic Diseases (18) · Mouth Diseases (17) · Pathological Conditions, Signs and Symptoms (6) · Respiratory Tract Diseases (4) · Skin Diseases (4) · Skin and Connective Tissue Diseases (4) · Genital Diseases (3) · Lichen Planus (3)
Cisplatin (8) · Docetaxel (6) · camrelizumab (4) · Carboplatin (3) · Fluorouracil (3) · tislelizumab (3) · Celecoxib (2) · sintilimab (2) · toripalimab (2) · 130-nm albumin-bound paclitaxel (1) · 26S proteasome non-ATPase regulatory subunit 13 (1) · Albumin-Bound Paclitaxel (1) · Aminolevulinic Acid (1) · Biopsy (1) · Blotting, Western (1)
Shanghai Jiao Tong University School of Medicine (4) · Cairo University (3) · Fayoum University (3) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (3) · Hospital of Stomatology, Wuhan University (2) · Privo Technologies (2) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (2) · Sun Yat-sen University (2) · Viome (2) · Academisch Ziekenhuis Maastricht (1) · Academy of Interdisciplinary Dental Education and Research (1) · Armed Forces Institute of Pathology Rawalpindi (1) · Barzilai Medical Center (1) · Cardarelli Hospital (1) · Case Comprehensive Cancer Center (1)
China (18) · United States (12) · Egypt (5) · France (4) · Italy (4) · India (2) · Pakistan (2) · Taiwan (2) · Australia (1) · Bangladesh (1) · Belgium (1) · Canada (1) · Croatia (1) · Finland (1) · Hong Kong (1)
Lai-ping Zhong, MD, PhD (2) · Alexandra Hernandez Levenston, PhD, MPH (1) · Ali Raza, B.D.S (1) · Angela Yoon, DDS (1) · Basim A Slim (1) · Charalampos Floudas, M.D. (1) · Cristina Julian (1) · Cristina Julian, PhD (1) · Diani Kartini, MD (1) · Dr. Dipayan Mojumder, BDS (1) · Gang Chen, M.D. (1) · Gang Chen, MD (1) · Guiqing Liao, MD, DDS (1) · Hana'a H Algadi, Msc student (1)
PMID 12543777, PMID 19037107, PMID 21743296, PMID 24415717, PMID 27411053, PMID 31002789, PMID 31072197, PMID 31118057, PMID 32372215, PMID 32823758, PMID 33238944, PMID 35534499, PMID 35734651, PMID 35977936, PMID 36159069, PMID 36999830, PMID 37650478, PMID 38087258, PMID 39317508, PMID 39889711, PMID 39931064, PMID 40107247, PMID 40655799, PMID 40855191
2008 (1), R03DE032972 (1), R21CA252441 (1), R44CA192875 (1), U01CA279862 (1)