3 terminated, 2 completed. 3 Phase 1, 1 Early Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Early Phase 1 | 1 | Terminated 1 |
| Phase 2 | 1 | Terminated 1 |
| Phase 3 | 1 | Terminated 1 |
Follow HDAC-42: new trials by email Literature Review of HDAC-42 trials Research Report on HDAC-42
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas REC-2282, Placebo - Neurofibromatosis Type 2 | Phase 2 / Phase 3 | Terminated | Recursion Pharmaceuticals Inc. | 25 | 2022-06-20 | 2026-08-17 |
| Study of the Pan-DAC Inhibitor AR-42 and Pazopanib in Advanced Sarcoma and Kidney Cancer AR-42, Pazopanib - Renal Cell Carcinoma, Soft Tissue Sarcoma | Phase 1 | Terminated | Virginia Commonwealth University | 6 | 2016-07-08 | 2019-10-24 |
| HDAC Inhibitor AR-42 and Pomalidomide in Treating Patients With Relapsed Multiple Myeloma Dexamethasone, HDAC Inhibitor AR-42, Laboratory Biomarker Analysis - Recurrent Plasma Cell Myeloma | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 9 | 2016-05-20 | 2021-06-15 |
| Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma AR-42 - Vestibular Schwannoma, Meningioma | Early Phase 1 | Terminated | Massachusetts Eye and Ear Infirmary | 7 | 2015-12-01 | 2025-12-05 |
| AR-42 and Decitabine in Treating Patients With Acute Myeloid Leukemia HDAC inhibitor AR-42, decitabine, laboratory biomarker analysis - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 1 | Completed | Alison Walker | 13 | 2013-09-17 | 2018-03-14 |
Neurofibromatosis 2 (2) · Carcinoma, Renal Cell (1) · Congenital Abnormalities (1) · Leukemia, Myeloid, Acute (1) · Meningioma (1) · Multiple Myeloma (1) · Neoplasm Metastasis (1) · Neurilemmoma (1) · Neuroma, Acoustic (1) · Sarcoma (1)
Alison Walker (1) · Massachusetts Eye and Ear Infirmary (1) · Ohio State University Comprehensive Cancer Center (1) · Recursion Pharmaceuticals Inc. (1) · Virginia Commonwealth University (1)
United States (5) · United Kingdom (1)
Alison Walker, MD (1) · Andrew S Poklepovic, MD (1) · Brad Welling, MD, PhD (1) · Yvonne Efebera, MD (1)
PMID 26943915, PMID 23660685, PMID 34667843
P30CA016059 (1)