491 terminated. 491 Phase 1, 160 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 491 | Terminated 491 |
| Phase 2 | 160 | Terminated 160 |
Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies Ketogenic diet - Developmental and Epileptic Encephalopathies, Epileptic Spasms | Phase 1 | Terminated | Heather Olson | 1 | 2025-08-11 | 2026-10-14 |
| A Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP441 Compared With Placebo in Participants With Narcolepsy Type 1 JZP441, Matching Placebo - Narcolepsy | Phase 1 | Terminated | Jazz Pharmaceuticals | 6 | 2025-05-13 | 2026-04-06 |
| Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults Radiprodil with Carbamazepine, Radiprodil with Itraconazole - Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia | Phase 1 | Terminated | GRIN Therapeutics, Inc. | 30 | 2025-05-08 | 2025-11-21 |
| A Phase 1b Study of the NLRP3 Inhibitor VENT-02 in Patients With Mild to Moderate Parkinson's Disease VENT-02, Placebo - Parkinson Disease | Phase 1 / Phase 2 | Terminated | Ventus Therapeutics U.S., Inc. | 29 | 2025-03-05 | 2025-10-29 |
| Mechanical Thrombectomy Blood Flow Reversal Mechanical thrombectomy via blood flow reversal using BOBBY balloon guide catheter - Stroke, Large Vessel Occlusion | Phase 1 | Terminated | MediSys Health Network | 3 | 2025-01-22 | 2025-07-24 |
| Study to Evaluate the Safety, Tolerability, and Efficacy of SRP-9004 Administered by Systemic Infusion in Limb Girdle Muscular Dystrophy Type 2D/R3 Participants in the United States SRP-9004 - Limb Girdle Muscular Dystrophy, Limb Girdle Muscular Dystrophy Type 2D/R3 | Phase 1 | Terminated | Sarepta Therapeutics, Inc. | 4 | 2025-01-09 | 2025-09-04 |
| Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD) ION269 - Alzheimer Disease, Down Syndrome | Phase 1 | Terminated | Ionis Pharmaceuticals, Inc. | 1 | 2024-12-20 | 2026-02-20 |
| A Study to Assess Nomlabofusp in Adolescents and Children With Friedreich's Ataxia Nomlabofusp, Placebo - Friedreich Ataxia | Phase 1 | Terminated | Larimar Therapeutics, Inc. | 18 | 2024-12-06 | 2026-07-10 |
| A Gene Transfer Therapy to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) Following Therapeutic Plasma Exchange (Plasmapheresis) in Participants With Duchenne Muscular Dystrophy (DMD) and Pre-existing Antibodies to AAVrh74 delandistrogene moxeparvovec, Plasmapheresis - Duchenne Muscular Dystrophy | Phase 1 | Terminated | Sarepta Therapeutics, Inc. | 3 | 2024-09-18 | 2025-09-04 |
| Ultrasonic Neuromodulation for Treatment of Cognitive Impairment Diadem prototype - Alzheimer Disease, Dementia | Phase 1 / Phase 2 | Terminated | University of Utah | 1 | 2024-08-18 | 2025-05-25 |
| Safety of Bryostatin in Patients With MS Bryostatin 1 - Multiple Sclerosis | Phase 1 | Terminated | Robert Fox | 4 | 2024-06-26 | 2026-03-31 |
| Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1) C134 Re-Administration - Recurrent Malignant Glioma, Glioblastoma Multiforme of Brain | Phase 1 | Terminated | University of Alabama at Birmingham | 1 | 2024-06-21 | 2026-01-22 |
| A Study of Imvotamab in Active, Refractory Idiopathic Inflammatory Myopathies Imvotamab - Idiopathic Inflammatory Myopathies, Inflammatory Myopathies | Phase 1 | Terminated | IGM Biosciences, Inc. | 2 | 2024-05-29 | 2025-02-11 |
| A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients TCD601 - ALS | Phase 1 | Terminated | ITB-Med LLC | 7 | 2024-04-16 | 2026-07-17 |
| A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01 ADEL-Y01 - healty participants, Placebo - Healthy Participants, ADEL-Y01 - MCI/AD - Alzheimer Disease | Phase 1 | Terminated | Alzheimer's Disease Expert Lab (ADEL), Inc. | 42 | 2024-02-06 | 2026-04-30 |
| Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer Combined use of SRS with Tucatinib, Trastuzumab, and Capecitabine - Brain Metastases, HER2-positive Breast Cancer | Phase 1 | Terminated | Baptist Health South Florida | 1 | 2024-01-29 | 2025-12-31 |
| A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) Following Imlifidase Infusion in Participants With Duchenne Muscular Dystrophy (DMD) Determined to Have Pre-existing Antibodies to Recombinant Adeno-Associated Virus Serotype (rAAVrh74) delandistrogene moxeparvovec, imlifidase - Duchenne Muscular Dystrophy | Phase 1 | Terminated | Sarepta Therapeutics, Inc. | 5 | 2024-01-29 | 2025-11-20 |
| Study of MK-6552 in Participants With Narcolepsy Type 1 (MK-6552-004) MK-6552, Placebo - Narcolepsy | Phase 1 | Terminated | Merck Sharp & Dohme LLC | 9 | 2024-01-24 | 2026-04-14 |
| A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS) VRG50635 - Amyotrophic Lateral Sclerosis | Phase 1 | Terminated | Verge Genomics | 54 | 2024-01-15 | 2025-12-15 |
| Study of Intramuscular Injections of ABBV-950 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Spasticity ABBV-950, BOTOX, Placebo for ABBV-950 - Upper Limb Spasticity | Phase 1 | Terminated | AbbVie | 1 | 2024-01-12 | 2024-07-01 |
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Brain Neoplasms (87) · Alzheimer Disease (49) · Glioblastoma (40) · Central Nervous System Neoplasms (36) · Glioma (31) · Multiple Sclerosis (31) · Astrocytoma (30) · Parkinson Disease (26) · Neoplasms (21) · Oligodendroglioma (21) · Gliosarcoma (19) · Stroke (16) · Amyotrophic Lateral Sclerosis (14) · Melanoma (14) · Breast Neoplasms (13)
Central Nervous System Diseases (320) · Brain Diseases (285) · Neoplasms by Site (145) · Nervous System Neoplasms (140) · Neoplasms (138) · Neurodegenerative Diseases (125) · Pathological Conditions, Signs and Symptoms (120) · Neoplasms by Histologic Type (107) · Neoplasms, Nerve Tissue (97) · Central Nervous System Neoplasms (96) · Neoplasms, Germ Cell and Embryonal (90) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (89) · Neuroectodermal Tumors (89) · Genetic Diseases, Inborn (87)
Temozolomide (18) · Radiotherapy (11) · Bevacizumab (6) · Cyclophosphamide (6) · Filgrastim (6) · Granulocyte Colony-Stimulating Factor (6) · Cetuximab (5) · Radiosurgery (5) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (4) · Magnetic Resonance Spectroscopy (4) · Mesna (4) · Radiation (4) · Rituximab (4) · Therapeutics (4) · Trastuzumab (4)
National Cancer Institute (NCI) (16) · M.D. Anderson Cancer Center (11) · Institute for Neurodegenerative Disorders (10) · Biogen (9) · H. Lundbeck A/S (9) · National Institute of Neurological Disorders and Stroke (NINDS) (8) · Pfizer (8) · Johns Hopkins University (7) · Sarepta Therapeutics, Inc. (7) · GlaxoSmithKline (6) · Pediatric Brain Tumor Consortium (6) · AbbVie (5) · Newron Sweden AB (5) · Northwestern University (5) · Novartis Pharmaceuticals (5)
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PMID 37624739, PMID 19717023, PMID 29480210, PMID 30052328, PMID 32250312, PMID 12411660, PMID 12542793, PMID 12749708, PMID 15746452, PMID 15864738, PMID 16899778, PMID 17188664, PMID 17293590, PMID 17909804, PMID 18356548, PMID 18418368, PMID 18425516, PMID 19065567, PMID 21903952, PMID 22232031, PMID 22294344, PMID 22766391, PMID 22789058, PMID 22828504, PMID 23118941, PMID 23369112, PMID 23642342, PMID 23733308, PMID 23773637, PMID 23982748, PMID 24088271, PMID 24327518, PMID 24410126, PMID 24412048, PMID 24705452, PMID 24759263, PMID 24792486, PMID 24916908, PMID 25133431, PMID 25223501, PMID 25442786, PMID 25613306, PMID 26590659, PMID 26857842, PMID 27055915, PMID 27143789, PMID 27295489, PMID 27424289, PMID 27574516, PMID 27582220
2014 (4), 2015 (4), 2018 (4), U01CA081457 (4), 2016 (3), 2009 (2), 2017 (2), 2019 (2), 2023 (2), N01NS42361 (2), P30CA043703 (2), U01CA069852 (2), 1RC2CA148491-01 (1), N01CM00032 (1), N01CM00039 (1)