20 completed, 5 recruiting, 4 unknown, 3 active not recruiting. 40 Phase 3, 11 Phase 2.
Follow Nephrosis: new trials by email Literature Review of Nephrosis trials Research Report on Nephrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zuberitamab in the First Episode of Paediatric Nephrotic Syndrome Zuberitamab, standard corticosteroid treatment - Nephrotic Syndrome | Phase 3 | Not yet recruiting | Children's Hospital of Fudan University | 120 | 2026-08-20 | 2026-08-14 |
| SGLT2 Inhibitors in Adult Primary Nephrotic Syndrome Dapagliflozin, Empagliflozin, Standard Therapy - Nephrotic Syndrome | Phase 2 / Phase 3 | Recruiting | Mansoura University | 75 | 2025-11-15 | 2026-06-09 |
| A Clinical Study of BAT4406F Injection in Patients With Minimal Change Disease/Focal Segmental Glomerulosclerosis BAT4406F, Placebos - Minimal Change Disease (MCD), Focal Segmental Glomerulosclerosis (FSGS) | Phase 2 / Phase 3 | Recruiting | Bio-Thera Solutions | 192 | 2025-10-26 | 2026-04-03 |
| Rituximab in the First Episode of Paediatric Nephrotic Syndrome Rituximab, Corticosteroid - Steroid-Sensitive Nephrotic Syndrome | Phase 3 | Not yet recruiting | Children's Hospital of Fudan University | 138 | 2025-03-01 | 2025-01-22 |
| REduced-dose Steroid PrOtocol for Childhood Nephrotic SyndromE (RESPONSE) Prednisone - Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change | Phase 3 | Active not recruiting | The Hospital for Sick Children | 50 | 2024-11-01 | 2026-05-11 |
| Efficacy and Safety of Tacrolimus in Combination With Ripertamab in the Initial Treatment of Patients With MCD Supportive care+Prednisone, Supportive care+Tacrolimus+Ripertamab, Supportive care+Ripertamab - Minimal Change Disease | Phase 3 | Not yet recruiting | Air Force Military Medical University, China | 81 | 2024-05-01 | 2024-05-08 |
| Study of the Telitacicept in Pediatric Patients With Frequently Relapsing or Steroid Dependent Nephrotic Syndrome Telitacicept - Nephrotic Syndrome in Children, Telitacicept | Phase 3 | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 20 | 2023-11-28 | 2024-08-21 |
| Study of Adrenocorticotropic Hormone on Children With Frequent Relapse or Steroid-dependent Nephrotic Syndrome: a Prospective, Multicenter, Randomized，Open-label Clinical Trial. Adrenocorticotrophic Hormone, Steroid - Nephrotic Syndrome in Children | Phase 3 | Recruiting | Mao Jianhua | 140 | 2023-11-01 | 2023-10-12 |
| Efficacy and Safety of Obinutuzumab Versus Rituximab in Childhood Steroid Dependant and Frequent Relapsing Nephrotic Syndrome single infusion of Rituximab, single infusion of Obinutuzumab - Steroid-Dependent Nephrotic Syndrome, Steroid-Sensitive Nephrotic Syndrome | Phase 2 / Phase 3 | Active not recruiting | Assistance Publique - Hôpitaux de Paris | 88 | 2023-10-18 | 2026-11-06 |
| Clinical Study of Rituximab for the Treatment for Idiopathic Membranous Nephropathy With Nephrotic Syndrome Rituximab (genetical recombination), Placebo - Glomerulonephritis, Membranous, Nephrotic Syndrome，Idiopathic | Phase 3 | Active not recruiting | Shoichi Maruyama MD PhD | 88 | 2023-06-24 | 2026-08-12 |
| A Study to Evaluate the Efficacy and Safety of Obinutuzumab Versus MMF in Participants With Childhood Onset Idiopathic Nephrotic Syndrome Obinutuzumab, MMF, Prednisone - Childhood Idiopathic Nephrotic Syndrome | Phase 3 | Completed | Hoffmann-La Roche | 85 | 2023-03-29 | 2026-10-14 |
| Ketoanalogues for Muscle Mass Loss in Nephrotic Syndrome Ketosteril, Medium Protein Diet (MPD) - Nephrotic Syndrome | Phase 3 | Recruiting | Military Institute od Medicine National Research Institute | 150 | 2023-01-03 | 2023-02-08 |
| Randomized Trial Evaluating Mycophenolate Mofetil in Children With Nephrotic Syndrome After Rituximab Treatment Rituximab, Mycophenolate Mofetil, Placebo tablets matching Mycophenolate Mofetil - Frequently Relapsing Nephrotic Syndrome, Steroid-Dependent Nephrotic Syndrome | Phase 3 | Withdrawn | Children's Hospital of Fudan University | 2021-01-01 | 2020-12-29 | |
| Study of Initial Steroid Treatment in Young Children With Nephrotic Syndrome Prednisolone, Placebo - Steroid-Sensitive Nephrotic Syndrome | Phase 3 | Withdrawn | Children's Hospital of Fudan University | 2021-01-01 | 2020-12-17 | |
| Amiloride in Nephrotic Syndrome Amiloride, Furosemide - Nephrotic Syndrome, Edema | Phase 3 | Terminated | University Hospital Tuebingen | 20 | 2020-06-08 | 2025-01-14 |
| Compare Efficacy and Safety of Repeated Courses of Rituximab to That of Maintenance Mycophenolate Mofetil Following Single Course of Rituximab Among Children With Steroid Dependent Nephrotic Syndrome Rituximab, Mycophenolate Mofetil - Steroid-Dependent Nephrotic Syndrome | Phase 3 | Completed | Nilratan Sircar Medical College | 100 | 2019-05-15 | 2024-12-17 |
| Efficacy and Safety of Immunoglobulin Associated With Rituximab Versus Rituximab Alone in Childhood-Onset Steroid-dependent Nephrotic Syndrome immunoglobulin IV - Steroid-Dependent Nephrotic Syndrome | Phase 2 / Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 73 | 2019-04-03 | 2026-10-29 |
| Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome Rituximab, Prednisone - Idiopathic Nephrotic Syndrome, Minimal Change Disease | Phase 3 | Unknown | Radboud University Medical Center | 40 | 2018-08-22 | 2018-08-27 |
| Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children Levamisole Hydrochloride, Placebo - First Manifestation of Steroid Sensitive Nephrotic Syndrome | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 86 | 2017-09-06 | 2022-06-08 |
| Valproic Acid for Idiopathic Nephrotic Syndrome Valproic Acid - Idiopathic Nephrotic Syndrome, Focal Segmental Glomerulosclerosis | Phase 2 / Phase 3 | Unknown | Universitair Ziekenhuis Brussel | 15 | 2016-10-01 | 2017-06-20 |
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Nephrotic Syndrome (32) · Nephrosis, Lipoid (13) · Glomerulosclerosis, Focal Segmental (6) · Kidney Diseases (3) · Proteinuria (3) · Glomerulonephritis, Membranous (2) · Amyloidosis (1) · Arthritis, Rheumatoid (1) · Edema (1) · Familial Mediterranean Fever (1) · Gastrointestinal Diseases (1) · Hypernatremia (1) · Macular dystrophy, corneal type 1 (1) · Neoplasm Metastasis (1)
Female Urogenital Diseases (40) · Female Urogenital Diseases and Pregnancy Complications (40) · Male Urogenital Diseases (40) · Urogenital Diseases (40) · Urologic Diseases (40) · Kidney Diseases (37) · Glomerulonephritis (8) · Nephritis (8) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (4) · Autoimmune Diseases (3) · Immune System Diseases (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3)
Rituximab (12) · Prednisone (9) · Prednisolone (6) · Mycophenolic Acid (4) · Adrenal Cortex Hormones (3) · Tacrolimus (3) · Adrenocorticotropic Hormone (2) · Cyclophosphamide (2) · Acetaminophen (1) · Amiloride (1) · Calcineurin Inhibitors (1) · Control Groups (1) · Dexamethasone (1) · Diphenhydramine (1) · Enoxaparin (1)
Assistance Publique - Hôpitaux de Paris (5) · Children's Hospital of Fudan University (4) · Military Institute od Medicine National Research Institute (2) · Nilratan Sircar Medical College (2) · Sun Yat-sen University (2) · Air Force Military Medical University, China (1) · All India Institute of Medical Sciences (1) · Asahi Kasei Therapeutics Corporation (1) · Bellus Health Inc. - a GSK company (1) · Bio-Thera Solutions (1) · Emory University (1) · Hoffmann-La Roche (1) · Istituto Giannina Gaslini (1) · Mansoura University (1) · Mao Jianhua (1)
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Qian Shen (2) · Anna Matyjek (1) · Anna Matyjek, MD, PhD (1) · Arvind Bagga, MD (1) · Biswanath Basu (1) · Debbie Gipson, MD (1) · Fanfan Hou, MD (1) · Feifei Xu, MD (1) · Ferruh Artunc, Prof., MD (1) · Fuming Lu, MD (1) · Gian Marco Ghiggeri, MD (1)
PMID 39513526, PMID 35224732, PMID 35230699, PMID 36456193, PMID 37678236, PMID 17554116, PMID 24480824, PMID 29913001, PMID 30385039, PMID 32967877, PMID 33256621, PMID 34778952, PMID 34884411, PMID 36223961, PMID 36990111, PMID 38707815, PMID 39171624, PMID 40337980, PMID 41448676
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