580 completed, 238 terminated, 232 recruiting, 98 active not recruiting. 1322 Phase 1, 395 Phase 2.
Follow Neoplasm Metastasis: new trials by email Literature Review of Neoplasm Metastasis trials Research Report on Neoplasm Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 1/2 Study of Personalized PSMA Radiopharmaceutical Therapy 177Lu-PSMA-I&T - escalating renal absorbed dose, 177Lu-PSMA-I&T - recommended phase 2 regime - Cancer, Prostate Cancer | Phase 1 / Phase 2 | Not yet recruiting | CHU de Quebec-Universite Laval | 500 | 2028-03-01 | 2025-03-30 |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| Study of ACC-1898 in Adult Participants With Advanced Solid Tumors ACC-1898 - Hepatocellular Carcinoma, Renal Cell Carcinoma | Phase 1 | Not yet recruiting | AccSalus Biosciences, Inc. | 40 | 2027-01-01 | 2026-10-28 |
| Study of ISM5939 in Patients With Advanced and/or Metastatic Solid Tumors ISM5939, Cisplatin, Docetaxel - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 | Not yet recruiting | InSilico Medicine Hong Kong Limited | 159 | 2026-12-30 | 2026-07-23 |
| An Investigational Study of BON-106 in Adults With Advanced or Metastatic Solid Tumors BON-106 - Solid Tumor, Advanced Solid Tumor | Phase 1 | Not yet recruiting | BeOne Medicines | 96 | 2026-12-01 | 2026-10-26 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Modified FOLFIRINOX and Pentamidine in Advanced and Metastatic Pancreatic Cancer modified FOLFIRINOX, Pentamidine 300 MG Injection - Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 1 | Not yet recruiting | University of Oklahoma | 30 | 2026-12-01 | 2026-09-18 |
| This is a Phase 1/1b Study to Evaluate the Safety and Preliminary Antitumor Activity of LTZ-232 in Participants With Advanced/Metastatic Colorectal Cancer and Other Solid Tumors LTZ-232 - Colorectal Cancer, Advanced/Metastatic Solid Tumor | Phase 1 | Recruiting | LTZ Therapeutics, Inc. | 152 | 2026-12-01 | 2026-10-20 |
| Safety and Efficacy Study in Adults With Advanced Solid Tumors Receiving REGN13089-M404-M2980, an Antibody-drug Conjugate That Targets MET Protein on Tumors REGN13089-M404-M2980 - Advanced Solid Tumors | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 320 | 2026-11-23 | 2026-10-07 |
| Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy Carfilzomib - Colorectal Neoplasms, Neoplasms | Phase 1 | Not yet recruiting | National Cancer Institute (NCI) | 20 | 2026-11-05 | 2026-11-02 |
| Y-NM600 in Patients Receiving Anti-PD-1 or Anti-PD-L1 for Metastatic Cancer 90Y-NM600 - Metastatic Cancer | Phase 1 | Recruiting | University of Wisconsin, Madison | 60 | 2026-11-01 | 2026-08-19 |
| A Study of MDSY-1240, a STAT3 Degrader, for the Treatment of Hematologic Malignancies and Advanced Solid Tumors MDSY-1240 - Triple-Negative Breast Cancer (TNBC), Gastric Cancer (GC) | Phase 1 / Phase 2 | Not yet recruiting | Medsyn Biopharma, LLC | 75 | 2026-11-01 | 2026-10-27 |
| A Study to Learn About the Study Medicine Called PF-08098488 in People With Advanced Solid Tumors. PF-08098488 - Pancreatic Ductal Adenocarcinoma, Esophageal Cancer | Phase 1 | Recruiting | Pfizer | 280 | 2026-10-29 | 2026-10-29 |
| CR-002 in Adult Participants With Locally Advanced or Metastatic Solid Tumors CR-002 - Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Gastric/GEJ | Phase 1 / Phase 2 | Recruiting | Crescent Biopharma, Inc. | 219 | 2026-10-21 | 2026-11-02 |
| Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer Biopsy Procedure, Biospecimen Collection, Echocardiography Test - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2026-10-06 | 2026-10-16 |
| ML-016 in Advanced Cancer With Lung and/or Liver Involvement ML-016 - Advanced Solid Tumor With Lung and/or Liver Involvement | Phase 1 / Phase 2 | Recruiting | BrYet US, Inc. | 108 | 2026-09-25 | 2026-10-05 |
| A Phase 1 Study of BPX-601 CAR T-Cell Therapy in Adult Participants With Prostate Cancer That Has Returned, is Resistant to Treatment and Has Spread BPX-601 - Prostate Cancer | Phase 1 | Recruiting | Regeneron Pharmaceuticals | 36 | 2026-09-08 | 2026-09-24 |
| A First-in-Human Study Investigating BG-85738 Alone or in Combination With Other Antitumor Agents in Patients With Advanced or Metastatic Solid Tumors With Rat Sarcoma Virus (RAS) Mutations BG-85738, Tislelizumab, Cetuximab - RAS Mutation, Advanced Solid Tumor | Phase 1 | Recruiting | BeOne Medicines | 100 | 2026-09-02 | 2026-10-23 |
| Combination Immunotherapy Treatment for Locally Advanced Unresectable or Metastatic, PD-L1 Negative (CPS<10), gBRCA Negative, Triple Negative Breast Cancer Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy BreakVax, Ipilimumab 2.5 mg, Pembrolizumab - Triple-Negative Breast Cancer (TNBC) | Phase 1 / Phase 2 | Not yet recruiting | BreakBio Corp | 10 | 2026-09-01 | 2026-08-19 |
| TLR9 Immunotherapy for Peritoneal Carcinomatosis ACM-CpG - Malignant Ascites, Colorectal Adenocarcinoma | Phase 1 | Recruiting | Brown University | 24 | 2026-08-25 | 2026-10-01 |
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Neoplasms (306) · Carcinoma, Non-Small-Cell Lung (204) · Breast Neoplasms (197) · Colorectal Neoplasms (178) · Melanoma (161) · Pancreatic Neoplasms (129) · Ovarian Neoplasms (113) · Lung Neoplasms (112) · Recurrence (99) · Stomach Neoplasms (94) · Prostatic Neoplasms (90) · Squamous Cell Carcinoma of Head and Neck (83) · Carcinoma, Renal Cell (81) · Triple Negative Breast Neoplasms (75)
Pathological Conditions, Signs and Symptoms (1322) · Neoplastic Processes (1318) · Pathologic Processes (1318) · Neoplasms (1016) · Neoplasms by Site (822) · Neoplasms by Histologic Type (476) · Skin and Connective Tissue Diseases (360) · Skin Diseases (359) · Digestive System Diseases (354) · Digestive System Neoplasms (349) · Neoplasms, Glandular and Epithelial (324) · Urogenital Diseases (281) · Urogenital Neoplasms (275) · Gastrointestinal Diseases (268) · Respiratory Tract Neoplasms (265)
pembrolizumab (109) · Gemcitabine (66) · Nivolumab (53) · Paclitaxel (51) · Cyclophosphamide (44) · Biopsy (40) · Cisplatin (40) · Specimen Handling (40) · Capecitabine (37) · Carboplatin (36) · Magnetic Resonance Spectroscopy (36) · Docetaxel (34) · Irinotecan (34) · Bevacizumab (33) · Fluorouracil (33)
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