35 completed, 13 recruiting, 9 unknown, 7 active not recruiting. 25 Phase 2, 12 Phase 1, 7 Not applicable, 4 Phase 3, 4 Phase 4.
Follow Perivascular Epithelioid Cell Neoplasms: new trials by email Literature Review of Perivascular Epithelioid Cell Neoplasms trials Research Report on Perivascular Epithelioid Cell Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Superselective Renal Artery Embolization for Renal Angiomyolipoma Selective endovascular embolization of kidney artery - Selective Endovascular Embolization of Kidney Artery | Active not recruiting | Botkin Hospital | 50 | 2026-04-06 | 2026-04-20 | |
| Ph 2 Elacestrant in ER Positive Uterine Sarcomas Elacestrant - Uterine Sarcoma, Uterine Leiomyosarcoma | Phase 2 | Recruiting | Dana-Farber Cancer Institute | 30 | 2026-03-25 | 2026-05-22 |
| A Study of Pembrolizumab in People With Ultra-Rare Sarcomas Pembrolizumab - Sarcoma | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 32 | 2025-12-04 | 2026-07-28 |
| Evaluating the Long-term Safety and Tolerability of Imatinib in Patients With Lymphangioleiomyomatosis (LAM) Imatimib Mesylate, Placebo - Lymphangioleiomyomatosis (LAM), Lymphangioleiomyomatosis | Phase 1 | Recruiting | Columbia University | 20 | 2025-10-20 | 2026-01-21 |
| Role of Extracellular Vesicles as Biomarkers of Pulmonary Involvement in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex Pulmonary Function Test, Analysis of Extracellular Vesicles - Lymphangioleiomyomatosis (LAM), Extracellular Vesicles; Generation and Function | Recruiting | University of Milan | 80 | 2025-04-16 | 2025-12-26 | |
| Ivonescimab in the Treatment of Multiple Advanced Tumors Ivocizumab - Pheochromocytoma/Paraganglioma, Rhabdomyosarcoma | Phase 2 | Recruiting | Fudan University | 400 | 2024-11-20 | 2025-08-24 |
| Evaluation of a Simple-Prep Controlled Embolic GPX® Embolic Device - Embolization, Vascular Tumor | Not applicable | Active not recruiting | Fluidx Medical Technology, Inc. | 114 | 2024-11-18 | 2026-03-30 |
| The Genotype and Phenotype of Lymphangioleiomyomatosis Sporadic Lymphangioleiomyomatosis, TSC-associated Lymphangioleiomyomatosis | Recruiting | National Taiwan University Hospital | 100 | 2024-05-10 | 2024-05-09 | |
| Tuberous Sclerosis Complex and Lymphangioleiomyomatosis Pregnancy Registry (TSC-LAM Registry) Tuberous Sclerosis Complex, Lymphangioleiomyomatosis | Recruiting | David M. Ritter | 300 | 2023-07-01 | 2026-01-23 | |
| A Phase IV Study of Safety and Efficacy of Everolimus in Taiwanese Patients With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma (TSC-AML) Everolimus - Renal Angiomyolipoma | Phase 4 | Active not recruiting | Novartis Pharmaceuticals | 4 | 2023-05-01 | 2026-09-17 |
| Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases Breath test using the Compact PTR-TOF-MS, Portable cardiac monitor "CardioQvark", Assessment of arterial stiffness using the VaSera VS-1500N - Chronic Respiratory Diseases, Cystic Fibrosis | Enrolling by invitation | I.M. Sechenov First Moscow State Medical University | 400 | 2023-01-30 | 2024-07-30 | |
| A Study of Safety and Efficacy of Sirolimus for Injection (Albumin-bound) in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumor (PEComa) Sirolimus for Injection (Albumin Bound) - Advanced Malignant Perivascular Epithelioid Cell Tumor (PEComa) | Phase 1 / Phase 2 | Unknown | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 54 | 2022-11-08 | 2022-11-28 |
| Lymphangioleiomyomatosis, a Study on Cathepsin K 24h urine, urine sample - Lymphangioleiomyomatosis, Tuberous Sclerosis Complex | Completed | University Hospital, Tours | 19 | 2022-05-31 | 2023-03-29 | |
| Characterizing LAM With 11C-Choline PET/CT 11C-Choline - Lymphangioleiomyomatosis | Early Phase 1 | Unknown | Peking Union Medical College Hospital | 50 | 2021-11-01 | 2021-10-21 |
| Effect of Loratadine in Lymphangioleiomyomatosis Loratadine, Placebo 10mg/day added to rapamycin for 12 months - Lymphangioleiomyomatosis | Phase 2 | Unknown | Institut d'Investigació Biomèdica de Bellvitge | 62 | 2021-11-01 | 2022-01-27 |
| Feasibility of [11C]Acetate-PET in LAM and TSC [11C]acetate - Lymphangioleiomyomatosis, Tuberous Sclerosis Complex | Phase 1 / Phase 2 | Active not recruiting | Brigham and Women's Hospital | 7 | 2021-08-30 | 2026-01-21 |
| Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group Patient with Soft Tissue Sarcoma - Soft Tissue Sarcoma, Clear Cell Sarcoma | Not applicable | Recruiting | Institut Claudius Regaud | 400 | 2021-04-26 | 2026-02-10 |
| Sleep Patterns in Patients Affected by Lymphangioleiomiomatosis LAM patients underwent PSG - Lymphangioleiomyomatosis, Sleep Disorder | Not applicable | Unknown | dr. Stefano Nava | 15 | 2020-06-30 | 2021-03-18 |
| Benefits of Pulmonary Rehabilitation in Patients With Severe Lymphangioleiomyomatosis (LAM) Pulmonary Rehabilitation - Lymphangioleiomyomatosis, LAM | Completed | Schön Klinik Berchtesgadener Land | 58 | 2019-12-03 | 2020-01-21 | |
| Molecular Characterization of Perivascular Epithelioid Cell Tumors Perivascular Epithelioid Cell Tumor, Malignant | Unknown | University Hospital, Strasbourg, France | 100 | 2019-12-01 | 2022-11-15 |
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Lymphangioleiomyomatosis (48) · Tuberous Sclerosis (19) · Angiomyolipoma (15) · Sarcoma (6) · Carcinoma, Renal Cell (4) · Carcinoma, Transitional Cell (4) · Lung Diseases (3) · Neoplasms (3) · Ascites (2) · Asthma (2) · Astrocytoma (2) · Carcinoma, Basal Cell (2) · Chordoma (2) · Desmoid Tumors (2)
Neoplasms by Histologic Type (69) · Neoplasms, Connective and Soft Tissue (69) · Neoplasms (66) · Hemic and Lymphatic Diseases (48) · Immune System Diseases (48) · Immunoproliferative Disorders (48) · Lymphatic Diseases (48) · Lymphoproliferative Disorders (48) · Neoplasm, Lymphatic Tissue (48) · Lymphangiomyoma (46) · Nervous System Diseases (23) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (22) · Genetic Diseases, Inborn (21) · Heredodegenerative Disorders, Nervous System (20)
Sirolimus (13) · Everolimus (7) · Imatinib Mesylate (2) · Nivolumab (2) · Bevacizumab (1) · Biopsy (1) · CTLA-4 Antigen (1) · Celecoxib (1) · Cetuximab (1) · Disulfides (1) · Doxorubicin (1) · Doxycycline (1) · Genetic Testing (1) · Glutamine (1) · Hydroxychloroquine (1)
National Heart, Lung, and Blood Institute (NHLBI) (8) · Novartis Pharmaceuticals (5) · University of Cincinnati (5) · Brigham and Women's Hospital (3) · Aadi Bioscience, Inc. (2) · Children's Hospital Medical Center, Cincinnati (2) · Dana-Farber Cancer Institute (2) · National Cancer Institute (NCI) (2) · Peking Union Medical College Hospital (2) · University Hospital, Strasbourg, France (2) · Assistance Publique - Hôpitaux de Paris (1) · Biorek S.R.L. (1) · Botkin Hospital (1) · CENTOGENE GmbH Rostock (1) · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (1)
United States (35) · France (10) · Italy (6) · Canada (5) · China (5) · Spain (4) · Russia (3) · Taiwan (3) · United Kingdom (3) · Brazil (2) · Germany (2) · Japan (2) · Albania (1) · Egypt (1) · Georgia (1)
Joel Moss, M.D. (4) · Francis X McCormack, MD (3) · Frank McCormack, MD (2) · Vincent Cottin, MD (2) · Aaron R Weiss (1) · Angelo M Taveira-DaSilva, M.D. (1) · Carlos RR Carvalho, PhD (1) · Carlos Roberto Ribeiro Carvalho, MD, PhD (1) · Carmen P Priolo, MD PhD (1) · Christopher Meinberg (1) · David J Kwiatkowski, MD PhD (1) · David M Ritter, MD, PhD (1) · Elizabeth P Henske, MD (1) · Erlinda M Gordon, MD (1)
PMID 21410393, PMID 12172553, PMID 18184959, PMID 21180274, PMID 21482669, PMID 21525172, PMID 21915260, PMID 23140536, PMID 23437092, PMID 24089446, PMID 24159565, PMID 24556663, PMID 24591665, PMID 25684695, PMID 25979023, PMID 26113676, PMID 26156073, PMID 26799509, PMID 26917604, PMID 28192114, PMID 28570161, PMID 29023494, PMID 30053159, PMID 30144422, PMID 30192751, PMID 30291925, PMID 30846465, PMID 31299246, PMID 31401903, PMID 31969335, PMID 32060062, PMID 32702309, PMID 32827353, PMID 32962746, PMID 33362722, PMID 33549601, PMID 33882143, PMID 34380663, PMID 34515544, PMID 34637337, PMID 34716198, PMID 36642366, PMID 36801466, PMID 36927115, PMID 36930738, PMID 37311055, PMID 37523624, PMID 38243705, PMID 38358334, PMID 38427923
1ZIAHL002541-21 (1), 2008 (1), P30CA006516 (1), R01CA107164 (1), R21CA103486 (1), R34HL138235 (1), U01HL058440 (1), U01HL131755 (1), U10CA098543 (1), U10CA180830 (1), U10CA180886 (1), U10CA180888 (1), U54HL127672 (1), U54RR019498 (1)