4 recruiting, 1 active not recruiting, 1 completed, 1 suspended. 3 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Recruiting 2, Suspended 1 |
| Phase 1 | 1 | Completed 1 |
Follow MSH6 Gene Mutation: new trials by email Literature Review of MSH6 Gene Mutation trials Research Report on MSH6 Gene Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection BEACON - Colorectal Cancer, Adenoma Colon | Recruiting | San Raffaele University | 1200 | 2024-01-01 | 2026-03-04 | |
| Lynch Syndrome X-Talk of Enteral Mucosa With Immune System LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System) - Lynch Syndrome, Lynch Syndrome I | Recruiting | San Raffaele University | 300 | 2023-06-01 | 2026-04-24 | |
| An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results Intervention Arm At-risk Relative/ARR Contacts, MyGene Portal, Standard of Care - BRCA1 Mutation, POLD1 Gene Mutation | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 1000 | 2022-12-01 | 2026-08-27 |
| Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome CASCADE genetic screening - BRCA-Mutated Ovarian Carcinoma, BRIP1 Gene Mutation | Active not recruiting | NYU Langone Health | 118 | 2019-03-01 | 2026-05-14 | |
| Videocapsule Endoscopy in Lynch Syndrome Video capsule endoscopy - Lynch Syndrome, Lynch Syndrome I | Not applicable | Recruiting | San Raffaele University | 100 | 2018-11-01 | 2026-04-22 |
| Durvalumab and Tremelimumab in Treating Patients With Microsatellite Stable Metastatic Colorectal Cancer to the Liver Durvalumab, Laboratory Biomarker Analysis, Tremelimumab - Metastatic Carcinoma in the Liver, MLH1 Gene Mutation | Phase 1 | Completed | City of Hope Medical Center | 9 | 2017-06-28 | 2019-12-26 |
| Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible) Educational Intervention, Genetic Counseling, Laboratory Biomarker Analysis - BARD1 Gene Mutation, BRCA1 Gene Mutation | Not applicable | Suspended | M.D. Anderson Cancer Center | 5200 | 2017-04-18 | 2026-08-26 |
Colorectal Neoplasms (3) · Colorectal Neoplasms, Hereditary Nonpolyposis (3) · Lynch Syndrome II (3) · Lynch syndrome I (site-specific colonic cancer) (2) · Turcot syndrome (2) · Colonic Diseases (1) · Colonic Neoplasms (1) · Endometrial Neoplasms (1) · Neoplastic Syndromes, Hereditary (1) · Triple Negative Breast Neoplasms (1)
Neoplasms (5) · Neoplasms by Site (5) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Gastrointestinal Diseases (4) · Gastrointestinal Neoplasms (4) · Intestinal Diseases (4) · Intestinal Neoplasms (4) · Colonic Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · DNA Repair-Deficiency Disorders (3) · Genetic Diseases, Inborn (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Rectal Diseases (3)
Capsule Endoscopy (1) · Disulfides (1) · Early Intervention, Educational (1) · Educational Status (1) · Genetic Counseling (1) · Immunoglobulin G (1) · Methods (1) · Standard of Care (1) · durvalumab (1) · tremelimumab (1)
San Raffaele University (3) · City of Hope Medical Center (1) · M.D. Anderson Cancer Center (1) · Memorial Sloan Kettering Cancer Center (1) · NYU Langone Health (1)
United States (5) · Italy (3)
Giulia Martina Cavestro, MD, PhD (2) · Bhavana Pothuri, MD (1) · Kenneth Offit, MD, MPH (1) · Marwan Fakih, MD (1) · Roni Wilke (1)