4 recruiting, 2 not yet recruiting, 2 unknown, 1 active not recruiting. 9 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Recruiting 4, Not yet recruiting 2, Active not recruiting 1, Unknown 1, Withdrawn 1 |
Follow Mitral Regurgitation Functional: new trials by email Literature Review of Mitral Regurgitation Functional trials Research Report on Mitral Regurgitation Functional
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TEER In dynaMic sEvere Functional Mitral Regurgitation (TIMER) TEER, GDMT - Mitral Regurgitation Functional | Not applicable | Not yet recruiting | Sun Yat-sen University | 540 | 2027-01-01 | 2026-09-04 |
| Achieving Optimal Medical Therapy Through Percutaneous Treatment of Secondary Mitral Regurgitation to Improve Outcome in Patients With HFrEF M-TEER, Standardized GDMT Up-Titration - Mitral Regurgitation Functional, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Recruiting | University Medical Center Mainz | 520 | 2026-10-15 | 2026-11-02 |
| Mitral Valve Edge-to-Edge Repair in Patients With Exercise-Induced Severe Mitral Regurgitation Guideline-Directed Medical Therapy (GDMT), Mitral valve TEER - Heart Failure - NYHA II - IV, Mitral Regurgitation Functional | Not applicable | Recruiting | Jena University Hospital | 246 | 2026-09-16 | 2026-10-05 |
| Early Feasibility Study (EFS) of the Nyra Cardiac Leaflet Enhancer (CARLEN) System CARLEN System - Mitral Regurgitation Functional | Not applicable | Recruiting | Nyra Medical, Inc. | 30 | 2026-07-02 | 2026-07-28 |
| Randomized Controlled Study of Dragonfly System for Functional Mitral Regurgitation DragonFly System, Drug - Mitral Regurgitation Functional | Not applicable | Not yet recruiting | Hangzhou Valgen Medtech Co., Ltd | 148 | 2025-12-30 | 2025-11-21 |
| Optimizing Clinical Outcomes in Patients Undergoing Mitral Transcatheter Edge-to-edge Repair (M-TEER) for Severe Functional Mitral Regurgitation Towards Improved Guideline-directed Medical Therapy Mitral transcatheter edge-to-edge repair - Mitral Regurgitation Functional, Heart Failure | Terminated | Institut für Pharmakologie und Präventive Medizin | 9 | 2025-04-01 | 2026-07-30 | |
| Treatment of Functional Mitral Regurgitation in Patients With Atrial Fibrillation Catheter Ablation and M-TEER - Atrial Fibrillation, Mitral Regurgitation Functional | Not applicable | Unknown | University of Luebeck | 66 | 2023-06-01 | 2023-05-06 |
| Safety and Effectiveness Study of Dragonfly System for Functional Mitral Regurgitation Dragonfly Transcatheter Mitral Valve Repair System - Mitral Regurgitation Functional | Not applicable | Recruiting | Hangzhou Valgen Medtech Co., Ltd | 120 | 2022-03-12 | 2022-03-29 |
| Percutaneous Mitral Valve Repair in Cardiogenic Shock: Mitra-Shock Study MitraClip implantation - Mitral Regurgitation Functional | Unknown | IRCCS San Raffaele | 30 | 2020-06-01 | 2020-06-09 | |
| A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation Millipede Transcatheter Annuloplasty Ring System (Millipede System) - Mitral Regurgitation Functional, Mitral Valve Disease | Not applicable | Active not recruiting | Boston Scientific Corporation | 4 | 2019-11-13 | 2026-10-23 |
| Noninferiority Trial of MitraClip Implantation Strategies: 1 Clip vs. 2 Clips in Patients With Functional Mitral Regurgitation MitraClip implantation - Mitral Regurgitation Functional | Not applicable | Withdrawn | Asklepios proresearch | 2018-05-01 | 2019-01-03 |
Mitral Valve Insufficiency (3) · Atrial Fibrillation (1) · Cardiovascular Diseases (1) · Heart Failure (1)
Cardiovascular Diseases (4) · Heart Diseases (4) · Heart Valve Diseases (3) · Arrhythmias, Cardiac (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Catheter Ablation (1) · Pharmaceutical Preparations (1)
Hangzhou Valgen Medtech Co., Ltd (2) · Asklepios proresearch (1) · Boston Scientific Corporation (1) · IRCCS San Raffaele (1) · Institut für Pharmakologie und Präventive Medizin (1) · Jena University Hospital (1) · Nyra Medical, Inc. (1) · Sun Yat-sen University (1) · University Medical Center Mainz (1) · University of Luebeck (1)
China (3) · Germany (3) · United States (2) · Australia (1) · Italy (1)
Christian Schulze, Prof. Dr. (1) · Jan-Malte Sinning, Prof. (1) · Jianan Wang (1) · Jianan Wang, MD, PH.D (1) · Karl-Heinz Kuck, MD, PHD (1) · Maximilian Spieker, PD Dr. (1) · Nicolas Van Mieghem, MD, PhD (1) · Philipp Lurz, Prof (1) · Robert Gooley, MBBS, PhD (1) · Susheel K Kodali, MD (1)