35 completed, 10 recruiting, 10 unknown, 8 terminated. 16 Phase 2, 15 Phase 3, 10 Phase 4, 4 Phase 1, 3 Not applicable.
Follow Microscopic Polyangiitis: new trials by email Literature Review of Microscopic Polyangiitis trials Research Report on Microscopic Polyangiitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases Dengue 1,2,3,4 (attenuated) vaccine - Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA) | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 477 | 2026-03-16 | 2026-07-20 |
| Comparison of a Strategy Based on Clinico-biological Monitoring Versus Pre-emptive Rituximab Treatment in Cases of ANCA Reappearance in Granulomatosis With Polyangiitis and Microscopic Polyangiitis. Rituximab - ANCA Associated Vasculitis (AAV), Polyangiitis (GPA) | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 70 | 2026-02-01 | 2026-03-05 |
| Safe Effective Therapy With Low-Dose Glucocorticoid in ANCA-Associated Vasculitis (SAFE-LOW) Cyclophosphamide, Standard of Care (SOC), Prednisone - Granulomatosis With Polyangiitis, Microscopic Polyangiitis (MPA) | Phase 3 | Recruiting | Ottawa Hospital Research Institute | 36 | 2025-11-10 | 2026-01-30 |
| Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA Rapcabtagene autoleucel, Active Comparator, Glucocorticoids - ANCA Associated Vasculitis (AAV) | Phase 2 | Active not recruiting | Novartis Pharmaceuticals | 126 | 2025-03-13 | 2026-09-04 |
| Avacopan vs Reduced-dose Glucocorticoids in ANCA-associated Vasculitis Avacopan, prednisolone and rituximab, Prednisolone and rituximab - ANCA Associated Vasculitis (AAV) | Phase 4 | Recruiting | Chiba University | 160 | 2024-11-15 | 2025-05-04 |
| Iptacopan in Patients With ANCA Associated Vasculitis Iptacopan, Placebo, Rituximab - Anti-Neutrophil Cytoplasm Antibodies (ANCA) Associated Vasculitis | Phase 2 | Active not recruiting | Novartis Pharmaceuticals | 84 | 2024-08-05 | 2026-10-15 |
| Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE) CD19- BCMA CAR-T cells - Systemic Lupus Erythematosus, Lupus Nephritis | Phase 1 / Phase 2 | Recruiting | Essen Biotech | 75 | 2024-07-10 | 2024-10-15 |
| Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM) SC291 - Lupus Erythematosus, Systemic Lupus Erythematosus | Phase 1 | Active not recruiting | Sana Biotechnology | 7 | 2024-04-29 | 2025-11-25 |
| Ocular Manifestations of Granulomatosis With Polyangiitis. Optical coherence tomography angiography - GPA, Vasculitis | Recruiting | Military Institute od Medicine National Research Institute | 70 | 2024-03-01 | 2026-06-24 | |
| PR3-AAV Resilient Remission or PRRR Obinutuzumab, Rituximab - Granulomatosis With Polyangiitis, Microscopic Polyangiitis | Phase 2 | Terminated | Mayo Clinic | 6 | 2023-06-30 | 2026-05-06 |
| An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases Povetacicept - Lupus Nephritis, Immunoglobulin A Nephropathy | Phase 1 / Phase 2 | Active not recruiting | Alpine Immune Sciences, Inc. | 72 | 2023-03-15 | 2026-10-20 |
| Special Drug Use-results Survey for Long-term Use（Avacopan） Avacopan - Microscopic Polyangiitis (MPA), Granulomatosis With Polyangiitis (GPA) | Recruiting | Kissei Pharmaceutical Co., Ltd. | 250 | 2022-07-29 | 2025-01-17 | |
| Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia. Procalcitonin-variants ELISA-Assay - Sepsis, Pre-Eclampsia | Completed | University Hospital Muenster | 30 | 2022-02-01 | 2024-06-04 | |
| Biosimilars of Rituximab in ANCA-associated Vasculitis Compared to the Originator ANCA-associated Vasculitis, Granulomatosis With Polyangiitis | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 201 | 2021-06-15 | 2025-12-02 | |
| Hydroxychloroquine in ANCA Vasculitis Evaluation Hydroxychloroquine, Placebo - ANCA Associated Vasculitis, Microscopic Polyangiitis | Phase 4 | Terminated | Guy's and St Thomas' NHS Foundation Trust | 43 | 2020-12-17 | 2026-04-29 |
| Efficacy and Safety of Rituximab in the Treatment of Good Prognosis Microscopic Polyangiitis Rituximab, placebo - Microscopic Polyangiitis (MPA) | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 8 | 2020-10-24 | 2026-05-06 |
| PRagmatic Analysis of Vitamin D in ANCA-Associated Vasculitis vitamin D - ANCA-associated Vasculitis, Granulomatosis With Polyangiitis | Not applicable | Completed | Christian Pagnoux | 102 | 2020-08-01 | 2023-03-14 |
| Urinary T Lymphocytes Predict Renal Flares in Patients With Inactive ANCA-associated Glomerulonephritis Analysis of urine samples with flow cytometry - Glomerulonephritis Acute | Completed | Charite University, Berlin, Germany | 100 | 2020-05-01 | 2023-11-14 | |
| Urinary T Cell Biomarker for Prediction in ANCA Glomerulonephritis Flow cytometry analysis of urine samples - Glomerulonephritis Acute | Unknown | Charite University, Berlin, Germany | 79 | 2019-11-19 | 2022-07-29 | |
| Study of IFX-1 to Replace Steroids in Patients With Granulomatosis With Polyangiitis and Microscopic Polyangiitis. IFX-1, Placebo-IFX-1, Glucocorticoid (GC) - Granulomatosis With Polyangiitis (GPA), Microscopic Polyangiitis (MPA) | Phase 2 | Completed | InflaRx GmbH | 57 | 2019-04-03 | 2022-08-25 |
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Granulomatosis with Polyangiitis (62) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (32) · Churg-Strauss Syndrome (26) · Vasculitis (26) · Polyarteritis Nodosa (17) · Takayasu Arteritis (13) · Giant Cell Arteritis (10) · IgA Vasculitis (8) · Behcet Syndrome (7) · Systemic Vasculitis (7) · Vasculitis, Central Nervous System (7) · Cryoglobulinemia, Familial Mixed (4) · Autoimmune Diseases (3) · Lupus Erythematosus, Systemic (3)
Brain Diseases (69) · Cardiovascular Diseases (69) · Central Nervous System Diseases (69) · Cerebral Small Vessel Diseases (69) · Cerebrovascular Disorders (69) · Immune System Diseases (69) · Nervous System Diseases (69) · Skin Diseases (69) · Skin and Connective Tissue Diseases (69) · Vascular Diseases (69) · Skin Diseases, Vascular (68) · Autoimmune Diseases (66) · Lung Diseases (63) · Respiratory Tract Diseases (63) · Lung Diseases, Interstitial (62)
Rituximab (16) · Azathioprine (10) · Cyclophosphamide (10) · Prednisone (7) · Glucocorticoids (5) · Methylprednisolone (5) · Mycophenolic Acid (5) · Blood Specimen Collection (3) · Methotrexate (3) · Plasma Exchange (3) · Prednisolone (3) · Infliximab (2) · avacopan (2) · vilobelimab (2) · AMG623 peptibody (1)
Assistance Publique - Hôpitaux de Paris (11) · University of Pennsylvania (8) · University of South Florida (5) · Cambridge University Hospitals NHS Foundation Trust (4) · Charite University, Berlin, Germany (2) · Chiba University (2) · Hospices Civils de Lyon (2) · InflaRx GmbH (2) · Mayo Clinic (2) · Novartis Pharmaceuticals (2) · University of Oxford (2) · Alpine Immune Sciences, Inc. (1) · Anthera Pharmaceuticals (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Christian Pagnoux (1)
United States (29) · France (19) · United Kingdom (16) · Canada (15) · Germany (8) · Japan (7) · Australia (6) · Czechia (6) · Italy (6) · Belgium (5) · Netherlands (5) · Sweden (5) · Switzerland (5) · China (4) · Denmark (4)
Peter A. Merkel, MD, MPH (7) · Peter A Merkel, MD, MPH (5) · Amanda M. Terry, MA (3) · Loic Guillevin, MD, PhD (3) · Peter Merkel, MD, MPH (3) · Megan Clowse, MD, MPH (2) · Peter C. Grayson, MD (2) · Ulrich Specks, MD (2) · Adrian Schreiber, PD Dr. med. (1) · Alan Salama (1) · Anja Pfaff, PhD (1) · Antoine Sreih, MD (1) · Arielle Mendel, MD MSc (1)
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