46 active not recruiting, 46 recruiting, 39 completed, 13 terminated. 95 Phase 1, 53 Phase 2, 15 Not applicable, 5 Early Phase 1, 5 Phase 3.
Follow Metastatic Malignant Solid Neoplasm: new trials by email Literature Review of Metastatic Malignant Solid Neoplasm trials Research Report on Metastatic Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Processes of Cancer Care Delivery at a Comprehensive Cancer Center Discussion, Electronic Health Record Review, Questionnaire Administration - Metastatic Malignant Solid Neoplasm | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2027-01-30 | 2026-09-11 | |
| Adoption of Audio Recording in the Outpatient Supportive Care Center Communication Intervention, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2026-12-30 | 2026-07-16 | |
| Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Metastatic Solid Tumors, ONE SHOT Trial Computed Tomography, Magnetic Resonance Imaging, MRI-guided Stereotactic Body Radiation Therapy - Metastatic Malignant Solid Neoplasm | Not applicable | Not yet recruiting | Jonsson Comprehensive Cancer Center | 25 | 2026-12-01 | 2026-08-24 |
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer Biopsy Procedure, Biospecimen Collection, Echocardiography Test - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2026-10-06 | 2026-10-16 |
| Adding Spatially Fractionated Radiation Therapy to Standard Palliative Radiation for Improving Disease-Related Symptoms in Patients With Unresectable Solid Tumors Electronic Health Record Review, External Beam Radiation Therapy, Questionnaire Administration - Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm | Not applicable | Recruiting | Mayo Clinic | 100 | 2026-09-23 | 2026-10-26 |
| BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion Biospecimen Collection, Computed Tomography, Pemetrexed - Metastatic Biliary Tract Carcinoma, Metastatic Colon Carcinoma | Phase 1 / Phase 2 | Recruiting | Northwestern University | 72 | 2026-08-21 | 2026-08-25 |
| Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor Trastuzumab Rezetecan - Solid Tumors, Neoplasms (Cancer / Tumors) | Phase 2 | Not yet recruiting | Haihua Yuan | 15 | 2026-06-15 | 2026-06-08 |
| Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies Psychotherapy, Psilocybin, Survey Administration - Anxiety, Depression | Phase 2 | Active not recruiting | University of Washington | 16 | 2026-05-19 | 2026-10-29 |
| Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study Biospecimen Collection, Immune Checkpoint Inhibitor - Advanced Biliary Tract Carcinoma, Advanced Head and Neck Squamous Cell Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 160 | 2026-04-24 | 2026-10-13 |
| STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma Aldesleukin, Biopsy, Biospecimen Collection - Locally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma | Phase 1 | Withdrawn | City of Hope Medical Center | 2025-12-05 | 2025-12-24 | |
| MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Metastatic Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm | Phase 1 | Recruiting | Mayo Clinic | 42 | 2025-11-07 | 2026-09-24 |
| TR-002 for the Treatment of Advanced Unresectable Metastatic Solid Tumors Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma TR-002 - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | University of California, Davis | 52 | 2025-11-07 | 2026-07-16 |
| Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors Biopsy, Biospecimen Collection, Computed Tomography - Metastatic Malignant Solid Neoplasm, Metastatic Melanoma | Phase 1 | Recruiting | Anusha Kalbasi | 18 | 2025-10-07 | 2026-03-17 |
| Imaging of Solid Tumors Using 18F-TRX 18F-TRX, Positron Emission Tomography (PET)/Computerized tomography (CT), Tumor Biopsy - Solid Tumor, Solid Carcinoma | Phase 1 | Recruiting | Rahul Aggarwal | 56 | 2025-07-03 | 2026-07-23 |
| Testing How the Body Responds to the Drug CX-5461 (Pidnarulex) in Patients With Metastatic Solid Cancers Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 40 | 2025-07-01 | 2026-09-16 |
| Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial Best Practice, Biospecimen Collection, Bone Metastases Treatment - Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm | Phase 3 | Active not recruiting | NRG Oncology | 280 | 2025-05-07 | 2026-08-17 |
| Studying TAK-243 in Patients With Advanced Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Lymphoma, Advanced Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 95 | 2025-03-24 | 2026-10-13 |
| Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial) Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 2 | Recruiting | National Cancer Institute (NCI) | 500 | 2025-03-18 | 2026-10-20 |
| Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning Internet-Based Intervention, Best Practice, Telephone-Based Intervention - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 400 | 2025-02-18 | 2026-08-17 |
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Neoplasm Metastasis (163) · Melanoma (25) · Lung Neoplasms (22) · Breast Neoplasms (18) · Carcinoma, Renal Cell (18) · Carcinoma, Non-Small-Cell Lung (16) · Colorectal Neoplasms (15) · Hematologic Neoplasms (14) · Ovarian Neoplasms (13) · Pancreatic Neoplasms (13) · Triple Negative Breast Neoplasms (12) · Brain Neoplasms (11) · Carcinoma, Transitional Cell (11) · Prostatic Neoplasms (9) · Carcinoma, Hepatocellular (8)
Neoplastic Processes (163) · Pathologic Processes (163) · Pathological Conditions, Signs and Symptoms (163) · Neoplasms (157) · Neoplasms by Site (90) · Neoplasms by Histologic Type (50) · Skin Diseases (42) · Skin and Connective Tissue Diseases (42) · Digestive System Diseases (39) · Digestive System Neoplasms (39) · Urogenital Diseases (38) · Neoplasms, Glandular and Epithelial (35) · Urogenital Neoplasms (35) · Carcinoma (33) · Female Urogenital Diseases (32)
Specimen Handling (59) · Magnetic Resonance Spectroscopy (47) · Biopsy (45) · Nivolumab (15) · Radiosurgery (14) · pembrolizumab (13) · CTLA-4 Antigen (10) · Ipilimumab (10) · Taxes (10) · Paclitaxel (9) · X-Rays (8) · olaparib (8) · Practice Guidelines as Topic (7) · Standard of Care (7) · trastuzumab deruxtecan (7)
National Cancer Institute (NCI) (59) · M.D. Anderson Cancer Center (39) · Mayo Clinic (11) · City of Hope Medical Center (7) · Fred Hutchinson Cancer Center (6) · University of Washington (4) · NRG Oncology (3) · OHSU Knight Cancer Institute (3) · Ohio State University Comprehensive Cancer Center (3) · Rahul Aggarwal (3) · Emory University (2) · Northwestern University (2) · Pamela Munster (2) · Rutgers, The State University of New Jersey (2) · SWOG Cancer Research Network (2)
United States (153) · Canada (10) · Puerto Rico (5) · Hong Kong (2) · Australia (1) · China (1) · Ireland (1) · Uganda (1)
Timothy A Yap (8) · Funda Meric-Bernstam (4) · A P Chen (3) · Aung Naing (3) · David S Hong (3) · Rahul Aggarwal, MD (3) · Sriram Yennu (3) · David Hui (2) · James Welsh (2) · Kristen R Spencer (2) · Megan J Shen, PhD (2) · Sarah Shin (2) · Sarina A Piha-Paul (2) · Yi-Jen Chen (2) · Aaron S. Mansfield, M.D. (1)
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